 | Clint Eastwood als Manco |
 | Lee Van Cleef als Col. Douglas Mortimer |
 | Gian Maria Volonté als El Indio |
 | Luigi Pistilli als Groggy, Member of Indio's Gang |
 | Klaus Kinski als Juan Wild - The Hunchback |
 | Joseph Egger als Old Prophet |
 | Panos Papadopulos als Sancho Perez, Member of Indio's Gang |
| Mara Krupp als Mary |
 | Benito Stefanelli als Luke 'Hughie' |
 | Roberto Camardiel als Tucumcari Station Clerk |
 | Aldo Sambrell als Cuchillo |
 | Luis Rodríguez als Manuel, Member of Indio's Gang |
 | Tomás Blanco als Tucumcari Sheriff |
 | Lorenzo Robledo als Tomaso, Indio's Traitor |
 | Sergio Mendizábal als Tucumcari Bank Manager |
 | Dante Maggio als Carpenter in Cell with El Indio |
| Diana Rabito als Callaway's Beautiful Girl in Tub |
| Giovanni Tarallo als Santa Cruz Telegraphist |
 | Mario Meniconi als Train Conductor |
 | Mario Brega als Niño, Member of Indio's Gang |
| José Terrón als Guy Calloway, Mortimer's 1st Criminal (uncredited) |
 | José Marco als 'Baby' Red Cavanaugh (uncredited) |
| Werner Abrolat als Slim, Member of Indio's Gang (uncredited) |
 | Frank Braña als Blackie, Member of Indio's Gang (uncredited) |
 | José Canalejas als Chico, Member of Indio's Gang (uncredited) |
 | Antonio Molino Rojo als Frisco, Member of Indio's Gang (uncredited) |
 | Jesús Guzmán als Carpetbagger on Train (uncredited) |
 | Ricardo Palacios als Tucumcari Saloon Keeper (uncredited) |
| Guillermo Méndez als White Rocks Sheriff (uncredited) |
 | Rosemary Dexter als Mortimer's Sister (uncredited) |
 | Peter Lee Lawrence als Mortimer's Brother-in-Law (uncredited) |
 | Kurt Zips als Hotel Manager (uncredited) |
 | Enrique Navarro als (uncredited) |
 | Bruno Corazzari als Poker Player (uncredited) |
| Carlo Simi als El Paso Bank Manager (uncredited) |
| Antoñito Ruiz als Fernando (uncredited) |
 | Román Ariznavarreta als Half-Shaved Bounty Hunter (uncredited) |
| Joseph Bradley als El Paso Tavern Keeper (uncredited) |
 | Fernando Di Leo als Cigar Smoking Card Player (uncredited) |
| Diana Faenza als Tomaso's Wife (uncredited) |
 | Eduardo García als Member of Indio's Gang (uncredited) |
| Maurizio Graf als The Balladeer (voice) (uncredited) |
| Francesca Leone als Tomaso's Baby (uncredited) |
 | Sergio Leone als Whistling Bounty Hunter (voice) (uncredited) |
| Rafael López als (uncredited) |
| Antonio Palombi als Bartender (uncredited) |
| Aldo Ricci als (uncredited) |
| Enrique Santiago als Miguel, Member of Indio's Gang (uncredited) |
 | Edmondo Tieghi als 2nd Agua Caliente Villager Watching Monco (uncredited) |
 | Antonio Montoya als Paco, Member of Indio's Gang (as José Montoya) |
| Arturo González | Producer |
| Ennio Morricone | Original Music Composer |
| Massimo Dallamano | Director of Photography |
| Giorgio Serrallonga | Editor |
| Juan Farsac | Makeup Artist |
| Carlo Simi | Costume Design |
| Sergio Leone | Director |
| Alberto Grimaldi | Producer |
| Sergio Leone | Screenplay |
| Luciano Vincenzoni | Screenplay |
| Eugenio Alabiso | Editor |
| Amedeo Alessi | Makeup Artist |
| Nosher Powell | Stunts |
| Rick Lester | Stunts |
| Manuel Castedo | Production Supervisor |
| Julio Sempere | Assistant Director |
| Ottavio Oppo | Production Manager |
| Benito Stefanelli | Stunt Coordinator |
| Norberto Solino | Production Supervisor |
| Sergio Donati | Additional Writing |
| Tonino Valerii | Assistant Director |
| Fernando Rossi | Production Supervisor |
| Eros Bacciucchi | Special Effects |
| Fernando Di Leo | Assistant Director |
| Fernando Di Leo | Additional Writing |
| Alfredo Fraile | Executive Producer |
| Giovanni Corridori | Special Effects |
| Aldo Ricci | Camera Operator |
| Rino Carboni | Makeup Department Head |
| Carlo Simi | Settings |
| Manuel Baquero | Special Effects |
| Bruno Nicolai | Music Director |
| Maurizio Graf | Musician |
| Oscar De Arcangelis | Sound |
| Domenico Parrello | Grip |
| Adriana Novelli | Supervising Editor |
| Mariano Canales | Script Supervisor |
| Montoro | Settings |
| Isabel Mellado | Assistant Makeup Artist |
| Mario Lommi | Assistant Camera |
| Isidro Muro | First Assistant Camera |
| Luis Beltrán | Local Casting |
| Bruno Battisti D'Amario | Musician |
| Ángel Cabero | Settings |
| Julio Ortas | Second Unit Director |
| Alessandro Alessandroni | Musician |
| Michele Lacerenza | Musician |
| Julio Ortas | Second Unit Director of Photography |
| Lothar Winkler | Still Photographer |
| Rafael Ferri | Assistant Decorator |
| Alberto Grimaldi | Presenter |
| Cantori Moderni Di Alessandroni | Musician |
| Ennio Morricone | Conductor |
| Carlo Leva | Assistant Art Director |
| Eduardo Noé | Camera Operator |
| Guido Ortenzi | Sound |
| Nino Culasso | Musician |
| Maria Luisa Rosen | Continuity |
| Antonio Palombi | Production Secretary |
| Luis Beltrán | Stunts |
| Arturo González | Presenter |
| Igino Lardani | Title Designer |
| Sergio Leone | Story |
| Fulvio Morsella | Story |
