 | Sam Worthington als Ray Monroe |
 | Lily Rabe als Joanne Monroe |
 | Stephen Tobolowsky als Dr. Berthram |
 | Adjoa Andoh als Dr. Isaacs |
 | Lauren Cochrane als Officer Childes |
 | Stephanie Sy als Nurse Anne |
 | Chad Bruce als Security Guard Jeff |
 | Derek James Trapp als Organ Orderly #2 |
| Dennis Scullard als Young Father |
| Will Woytowich als State Trooper |
| Chris Sigurdson als Dr. Lucado |
| Ernesto Griffith als Ward Intern / Janitor |
 | Dorothy Carroll als Admissions Clerk / Scrub Nurse |
| Muriel Hogue als Gas Station Attendant |
| Mark Dann als Flashback Paramedic |
 | Gabriel Daniels als Orderly Drew |
 | Marina Stephenson Kerr als Receptionist #1 |
 | Erik Athavale als Dr. Bruce Volk |
| Muriel Hogue als Store Cashier |
 | Jeff Strome als Paramedic / Anesthesiologist |
| Ernesto Griffith als Medican Intern / Janitor |
 | Adrian McLean als Sick Man |
| Will Woytowich als State Cop #1 |
 | Alan Castanga als Friendly Orderly |
 | Ernie Pitts als Code Blue Doctor |
| Jessica Burleson als Desk Nurse Restricted Area |
 | Frederick Allen als Man in Line |
| Derek James Trapp als Morgue Orderly #2 |
 | Shane Dean als Officer Griggs |
 | Cheryl Soluk als Knitting Woman |
 | Natalie Malaika als Receptionist #2 |
 | Lucy Capri als Peri Monroe |
| Robert Mead | Editor |
| Tiffany Murray | Camera Operator |
| Billy Higgins | Executive Producer |
| Mike Macari | Producer |
| Steven K. Johnson | Second Assistant Camera |
| Brad Anderson | Director |
| Jessica Jacobs | Associate Producer |
| Paul Schiff | Producer |
| Alan B. McElroy | Writer |
| Ian Dimerman | Executive Producer |
| Neal Edelstein | Producer |
| Sheila Jaffe | Casting |
| Lauren Crasco | Production Design |
| Réjean Labrie | Art Direction |
| Sandra Soke | Costume Design |
| Lisa Cichelly | Production Manager |
| Bryan R. Burns | Second Assistant Director |
| Peter Mabrucco | Second Assistant Director |
| Robert Borges | Stunts |
| Kara Wooten | Stunt Double |
| David Franceschetti | Assistant Director |
| Cindy Rago | Visual Effects Producer |
| Nina Kvaternik | Makeup Artist |
| Puneet Chawla | Second Assistant Director |
| Ian Yunis | Visual Effects |
| BJ Verot | Stunt Double |
| Brenda Magalas | Makeup Department Head |
| Chris LeDoux | Visual Effects Producer |
| Sean Skene | Stunt Coordinator |
| Tonya Smay | Digital Compositor |
| Andrew Budyk | Set Designer |
| Lloyd Brandson | Key Scenic Artist |
| Travis Marszalek | Hair Designer |
| Martin Boksar | Matte Painter |
| Blake Goedde | Visual Effects Supervisor |
| Brandon Kachel | Matte Painter |
| Stacey Mendoza | Hair Department Head |
| Casey Markus | Special Effects Coordinator |
| Davin MacRae | Special Effects |
| Saeed Faridzadeh | Digital Compositor |
| Jake Kennerd | Stunt Double |
| Doug Morrow | Special Effects Makeup Artist |
| Steve Newburn | Prosthetics |
| Kristen Sawatzky | Stunt Double |
| Liz Gallacher | Music Supervisor |
| Billy Higgins | Line Producer |
| Jim Heber | Casting |
| Billy Higgins | Unit Production Manager |
| Adam Druxman | First Assistant Director |
| Edgar Ozolins | Production Sound Mixer |
| Dallas Pomedli | Boom Operator |
| Eric Neufeld | Boom Operator |
| Catherine Farrell | Associate Producer |
| Catherine Farrell | Post Production Supervisor |
| Donna Jenkyns | Art Department Coordinator |
| Mark Stratton | Property Master |
| Aaron W.R. Johnston | Assistant Property Master |
| Jennifer Omoth | Production Accountant |
| Trevanna Post | Post Production Accountant |
| Bernard Narvey | Location Manager |
| Laurence Mardon | Gaffer |
| Eric Zachanowich | Still Photographer |
| Kari Rieger | Extras Casting |
| Eleanor Erum | Extras Casting |
| Olaf Dux | Construction Coordinator |
| Ron Bochar | Sound Re-Recording Mixer |
| Ron Bochar | Sound Designer |
| Sara Stern | Dialogue Editor |
| Mick Gormaley | Music Editor |
| Ruth Hernandez | ADR Editor |
| Sarah Streit | Assistant Sound Editor |
| Steven Visscher | Foley Editor |
| Marko Costanzo | Foley Artist |
| Margaret Lewis | Digital Intermediate Producer |
| Björn Charpentier | Director of Photography |
| Anton Sanko | Original Music Composer |
| Alyssa Koncelik-Diemer | VFX Artist |
| Chrussy | Location Production Assistant |
| Rick Skene | Stunt Driver |
| Dan Skene | Stunt Driver |
| Krystle Snow | Stunt Driver |
| Allan Wallace Dunkeld | Stunts |
| Rawleigh Clements-Willis | Stunt Driver |
| Anders Strome | Stunts |
| Kye Walstrom | Stunt Driver |
| Lucy Capri | Stunts |
| Tristan Carlucci | Stunts |
| Alan Castanga | Stunts |
| Jeff Sanca | Stunt Driver |
