 | Ryan Reynolds als Guy |
 | Jodie Comer als Millie Rusk / Molotovgirl |
 | Joe Keery als Walter 'Keys' McKeys |
 | Lil Rel Howery als Buddy |
 | Utkarsh Ambudkar als Mouser |
 | Taika Waititi als Antwan Hovachelik |
 | Channing Tatum als Revenjamin Buttons |
 | Aaron W Reed als Dude |
 | Britne Oldford als Barista |
 | Camille Kostek als Bombshell |
 | Mark Lainer als Hostage |
 | Mike Devine als Officer Johnny |
 | Sophie Levy als Big City Dreamer |
| Vernon Scott als Bank Manager |
 | Naheem Garcia als Convenience Store Owner Joe |
| Anabel Graetz als Cat Lady Phyllis |
| Ric Plamenco als Ice Cream Vendor |
 | Kenneth Israel als Businessman |
 | Michael Malvesti als Newsstand Vendor |
 | Colin Allen als Shoe Store Clerk |
 | Michael Tow als Rain Man |
 | Hugh Jackman als Masked Player in Alley (voice) |
 | Dwayne Johnson als Bank Robber #2 (voice) |
 | Tina Fey als Vacuuming Mom (voice) |
 | John Krasinski als Silhouetted Gamer (voice) |
 | Chris Evans als Chris Evans |
 | Alex Trebek als Alex Trebek |
 | Lara Spencer als Lara Spencer |
 | Matthew Cardarople als Keith, the 22-Year-Old Gamer |
| Jonathan De Azevedo als Jonathan |
| Destiny Claymore als Art Nerd |
 | Ninja als Ninja |
 | Pokimane als Pokimane |
 | Lannan Eacott als Lazarbeam |
 | Seán McLoughlin als Jacksepticeye |
 | DanTDM als DanTDM |
 | Charlotte Levy als Tween Gamer Girl |
| Colette Levy als Foul-Mouthed Little Sister |
| Mariama Conde als Teenage Girl |
| Olivia Z. Cote als Teenage Girl |
| Ryan Doyle als Teenage Boy |
| Bob Gilliam als Free City News Anchor |
| Terri Schwartz als IGN Reporter |
 | Eugene Nomura als Japanese Reporter |
| Euri Nomura als Hinata |
 | Octavia Chavez-Richmond als Real World Coffee Shop Server |
 | Raj Jawa als Quad-Screen Gamer |
| Charlie Lehmer als Quad-Screen Gamer |
| Elainy Mata als Quad-Screen Gamer |
| Jack McLaglen als Quad-Screen Gamer |
 | Jose Guns Alves als Soonami Security Guard |
| Minh-Anh Day als Soonami Employee |
| Ella Faria als Austrian Female Gamer |
| Francisco Marquez als Bank Robber #1 |
 | Owen Burke als Bank Robber #2 |
 | Timothy John Smith als Bank Robber #3 |
| Justin Johnston als Bank Robber #4 |
 | Patrick Vincent Curran als Masked Player in Alley |
| Lily Steven als 20-Year-Old Female Gamer |
 | Gabrielle Lorthe als 20-Year-Old Female Gamer |
| Briana Mitchell als 20-Year-Old Female Gamer |
| Rosario Corso als Silhouetted Gamer |
 | Regina Taufen als Vacuuming Mom |
| Liam Campos als Kid Gamer |
| Piper Acord als Contestant |
| Brett Schneider als Contestant |
 | Omar Ghonim als Carjacking Victim (uncredited) |
 | Tait Fletcher als Viking Warrior (uncredited) |
 | Janelle Feigley als Jogger (uncredited) |
 | Brandon Scales als Businessman (uncredited) |
| Greg Berlanti | Producer |
| Ryan Reynolds | Producer |
| Sarah Schechter | Producer |
| Shawn Levy | Director |
| Shawn Levy | Producer |
| Josh McLaglen | First Assistant Director |
| Christopher Conroy | Set Dresser |
| Steve Cooper | Art Direction |
| Lori Gomes | Hair Setup |
| Charles Cooley | Special Effects Technician |
| Beat Frutiger | Supervising Art Director |
| Joel Reidy | Boom Operator |
| Marlene Stewart | Costume Design |
| Robert McKinnon | Concept Artist |
| Tom Williams | Sound Mixer |
| Ethan Tobman | Production Design |
| Leslie E. Rollins | Set Decoration |
| Isaac Nadreau | Stage Director |
| Jennifer LaFace | Propmaker |
| Kelly Walton | Props |
| Freddy Bouciegues | Fight Choreographer |
| Douglas Cowell | Extras Casting Coordinator |
| Tyler Swanek | Loader |
| Maurice K. McGuire | Camera Operator |
| Alan Markfield | Still Photographer |
| Brandon Beckman | Stunt Driver |
| John Ruggieri | Pyrotechnician |
| Matt Magnolia | Visual Effects Coordinator |
| Adam Peabody | Electrician |
| Eric Swanek | First Assistant "A" Camera |
| Daniel Stevens | Stunt Double |
| Joseph Battista | Grip |
| Greg Wimer | First Assistant "B" Camera |
| Mark Fitzgerald | Location Manager |
| Jyothi Kalyan Sura | Visual Effects Art Director |
| Nico Coucke | Stunts |
| George Dewey | Executive Producer |
| Carolina Jiménez | Layout |
| Matt Lieberman | Screenplay |
| Stephanie Portnoy Porter | Assistant Costume Designer |
| Zak Penn | Screenplay |
| Josh McLaglen | Executive Producer |
| Michael McGrath | Executive Producer |
| Mary McLaglen | Executive Producer |
| Matt Lieberman | Story |
| George Richmond | Director of Photography |
| Adam Kolbrenner | Producer |
| Daniel S. Levine | Executive Producer |
| Anthony Hoang | Stunts |
| Christophe Beck | Original Music Composer |
| Dean Zimmerman | Editor |
| Teddy Pryor | Production Assistant |
| Tanaz Nili | Makeup Artist |
| Angela Marinis | Makeup Artist |
| Russell Earl | Visual Effects Supervisor |
| Swen Gillberg | Visual Effects Supervisor |
| Jamie Hallett | Visual Effects Supervisor |
| David Grimaldi | Sound Designer |
| Ai-Ling Lee | Sound Designer |
| Angelo Palazzo | Sound Designer |
| XD | Video Assist Operator |
| Rand Geiger | Co-Producer |
| Dan Cohen | Co-Producer |
| Scott Elias | Associate Producer |
| Ronna Kress | Casting |
| Lisa Lobel | Casting |
| Angela Peri | Casting |
| Michael A. King | Additional Hairstylist |
| Lori McCoy-Bell | Hair Department Head |
| Kelly Muldoon | Assistant Hairstylist |
| Joanna Raskin | Additional Hairstylist |
| Greg Aronowitz | Prop Maker |
| Matthias Beeguer | Concept Artist |
| Aimee Butterfield | Props |
| Stanley Bystrowski | Props |
| Jonathan Champoux | Set Dresser |
| James Carson | Concept Artist |
| Frans Wetterings III | Gaffer |
| Richard Schoen | Costume Supervisor |
| Masha Kurenkov | Art Department Assistant |
| Alex Trebek | In Memory Of |
| Wale | Musician |
| Logic | Musician |
| Mariah Carey | Musician |
| Rosine 'Ace' Hatem | Stunts |
| Trevor Logan | Stunts |
| Chris Palermo | Stunt Driver |
| Keith Woulard | Stunts |
| Vanessa Zamarripa | Stunts |
| Buddy Joe Hooker | Stunts |
| Chris O'Hara | Second Unit Director |
| Chris O'Hara | Stunt Coordinator |
| Clay Cullen | Stunt Driver |
| Jeremy Fry | Stunt Driver |
| Tait Fletcher | Stunts |
| Jodi Michelle Pynn | Stunts |
| Daniel Hourihan | Electrician |
| Hayley Wright | Stunts |
| Craig Henighan | Sound Re-Recording Mixer |
| Craig Henighan | Supervising Sound Editor |
| Victoria Lee Parella | Stunts |
| Anthony Raymond | Set Designer |
