 | Carrie Coon als Callie Spengler |
 | Finn Wolfhard als Trevor |
 | Mckenna Grace als Phoebe |
 | Paul Rudd als Gary Grooberson |
 | Logan Kim als Podcast |
 | Celeste O'Connor als Lucky |
 | Bill Murray als Dr. Peter Venkman |
 | Dan Aykroyd als Dr. Raymond Stantz |
 | Ernie Hudson als Winston Zeddemore |
 | Annie Potts als Janine Melnitz |
 | Sigourney Weaver als Dana Barrett |
 | Bokeem Woodbine als Sheriff Domingo |
 | Tracy Letts als Jack (uncredited) |
 | J.K. Simmons als Ivo Shandor |
 | Josh Gad als Muncher (voice) |
 | Bob Gunton als The Ghost Farmer |
 | Billy Bryk als Zahk |
 | Sydney Mae Diaz als Swayze |
 | Shawn Seward als Skittles |
 | Hannah Duke als Reseda |
 | Paulina Jewel Alexis als Bunny |
 | Marlon Kazadi als Thick Neck |
| Chiara Petersen als Burner Girl |
 | Danielle Kennedy als Roller Granny |
 | Artoun Nazareth als Rufus |
| Crystal Roseborough als Crystal |
 | Dusan Rokvic als Landlord |
| Emma Portner als Spirit of Gozer |
 | Stella Aykroyd als Deputy Medjuck |
| Kim Faires als Waitress |
 | Shohreh Aghdashloo als Gozer (voice) |
 | Olivia Wilde als Gozer the Gozerian (uncredited) |
 | Harold Ramis als Dr. Egon Spengler (archive footage) |
 | Oliver Cooper als Elton (uncredited) |
 | CJ Collard als Diner Patron (uncredited) |
 | Bud Klasky als Sheriff / Restaurant (uncredited) |
 | Faith Louissaint als Diner Counter Staff (uncredited) |
 | Daniel D'Angelo Sparks als Walmart Customer (uncredited) |
| John Papsidera | Casting |
| Dan Aykroyd | Executive Producer |
| Dan Aykroyd | Original Film Writer |
| Harold Ramis | Original Film Writer |
| Danny Glicker | Costume Design |
| Ivan Reitman | Producer |
| François Audouy | Production Design |
| Jason Reitman | Director |
| Jason Reitman | Writer |
| Eric Steelberg | Director of Photography |
| Dana E. Glauberman | Editor |
| Tom Pollock | Executive Producer |
| Guy Bews | Stunt Coordinator |
| Gil Kenan | Executive Producer |
| Gil Kenan | Writer |
| Joe Medjuck | Executive Producer |
| Michael Beugg | Executive Producer |
| Scott Meehan | Art Direction |
| Tom Reta | Art Direction |
| Michael Lemon | VFX Artist |
| Peter Stratford | Set Designer |
| Rob Simonsen | Original Music Composer |
| Aaron L. Gilbert | Executive Producer |
| Chris Terhune | Sound Designer |
| Jason Blumenfeld | Executive Producer |
| Perry Robertson | Supervising Sound Editor |
| Jason Cloth | Executive Producer |
| Will Files | Supervising Sound Editor |
| Will Files | Sound Re-Recording Mixer |
| Mark Paterson | Sound Re-Recording Mixer |
| Sheena Duggal | Visual Effects Supervisor |
| Joanne Jacobsen | Makeup Department Head |
| Scott Sanders | Sound Designer |
| Laura Geucherian | Finishing Producer |
| Bill Ives | Art Direction |
| Paul Healy | Set Decoration |
| Joel Tobman | Assistant Art Director |
| Steven Morrow | Sound Mixer |
| Kevin Zimmerman | Sound Editor |
| Ed Symon | Set Designer |
| Sarah Moussaif | Visual Effects Producer |
| Chris LeDoux | Visual Effects |
| Tracey Graham | Set Costumer |
| Sid Jayakar | Visual Effects Supervisor |
| Doug Spilatro | VFX Artist |
| Katrina Sainz | Assistant Art Director |
| Vasilios Tanis | Makeup Artist |
| Martin Chabannes | VFX Artist |
| Eric Reich | Co-Producer |
| Bryan Yaconelli | Associate Producer |
| Evan Spence | Set Designer |
| Carole Griffin | Costume Supervisor |
| Paul Boyd | VFX Artist |
| Kerry Joseph | Visual Effects Producer |
| Kerry Joseph | Associate Producer |
| Philip Marvin | Associate Producer |
| Patrice Avery | Producer |
| Chris Van Dyck | Visual Effects Supervisor |
| James Isaacson | Props |
| C.J. Hannis | Cast Driver |
| Steven Kajorinne | Set Dresser |
| Ashley MacMillan | Props |
| Jesse Morrow | Visual Effects Producer |
| Erica Mills | Co-Producer |
| Charley Carlat | VFX Artist |
| Jan Jinda | VFX Artist |
| Nathan Orloff | Editor |
| Amie Karp | Executive Producer |
| Ashley Levinson | Co-Executive Producer |
| Chris Cortner | Set Designer |
| Pier Lefebvre | Visual Effects Supervisor |
| Aharon Bourland | Visual Effects Supervisor |
| Reetu Aggarwal | VFX Artist |
| Adam Somer | Co-Executive Producer |
| Sara Emack | Visual Effects Producer |
| Michelle Kee | Visual Effects Producer |
| Cathy Shaw | VFX Artist |
| Daniel Hazeltine | VFX Artist |
| Lorna Barnshaw | VFX Artist |
| Alvaro Garcia | VFX Artist |
| Sanchit Anant | VFX Artist |
| Lahiru Jay | VFX Artist |
| Christoph Westphal | VFX Artist |
