 | Ian McKellen als James Whale |
 | Brendan Fraser als Clayton Boone |
 | Lynn Redgrave als Hanna |
 | Lolita Davidovich als Betty |
 | David Dukes als David Lewis |
 | Kevin J. O'Connor als Harry |
 | Mark Kiely als Dwight |
 | Jack Plotnick als Edmund Kay |
 | Rosalind Ayres als Elsa Lanchester |
 | Jack Betts als Boris Karloff |
 | Matt McKenzie als Colin Clive |
 | Todd Babcock als Leonard Barnett |
 | Cornelia Hayes O'Herlihy als Princess Margaret |
| Brandon Kleyla als Young Whale |
 | Pamela Salem als Sarah Whale |
 | Michael O'Hagan als William Whale |
 | David Millbern als Dr. Payne |
 | Amir Aboulela als The Monster |
| Marlon Braccia als Elizabeth Taylor |
| Jesse Long als Assistant Director |
 | Owen Masterson als Camera Assistant |
| Lisa Vastine als Librarian |
| Kent George als Whale at 25 |
 | Martin Ferrero als George Cukor |
 | David Fabrizio als Photographer |
 | Jesse James als Michael Boone |
 | Lisa Darr als Dana Boone |
| Paul Michael Sandberg als Sound Man |
 | Judson Mills als Young Man at Pool |
 | Arthur Dignam als Ernest Thesiger (uncredited) |
 | John Gatins als Kid Saylor (uncredited) |
 | Curtis Harrington als Cukor Party Guest (uncredited) |
 | Celeste Lecesne als Jack Pierce (uncredited) |
 | Sarah Ann Morris als Daisy (uncredited) |
| Richard Pines als Bar Patron (uncredited) |
| Jennifer Tolkachev als Party Guest (uncredited) |
| Debra-Lee Davidson | Makeup Artist |
| Jim Samson | Set Decoration |
| Richard Sherman | Set Designer |
| Christopher Bram | Novel |
| Gregg Fienberg | Producer |
| Mark R. Harris | Producer |
| Stephen M. Katz | Director of Photography |
| Bill Condon | Director |
| Bill Condon | Screenplay |
| Valorie Massalas | Casting |
| Bruce Finlayson | Costume Design |
| Paul Colichman | Producer |
| Brian Smith | ADR Mixer |
| Clive Barker | Executive Producer |
| Beau Rogers | Executive Producer |
| Richard Sherman | Production Design |
| Stephen P. Jarchow | Executive Producer |
| David Bach | Supervising Sound Editor |
| David Forrest | Executive Producer |
| Virginia Katz | Editor |
| Sam Irvin | Co-Executive Producer |
| Lisa Levy | Line Producer |
| Valorie Massalas | Co-Executive Producer |
| Spencer Proffer | Co-Executive Producer |
| John Schouweiler | Line Producer |
| Carter Burwell | Original Music Composer |
| David Larry | Art Direction |
| Judy Crown | Key Hair Stylist |
| Sheryl Blum | Hairstylist |
| Tarra D. Day | Key Makeup Artist |
| Carol F. Doran | Wigmaker |
| Cyndra Dunn | Makeup & Hair |
| Kim M. Ferry | Hairstylist |
| Rita L. Green | Makeup & Hair |
| Robert Hallowell II | Hairstylist |
| Jerry Macaluso | Makeup Supervisor |
| Robin McWilliams | Hairstylist |
| Nina Minster | Makeup Artist |
| Cindy Nakadaira | Makeup & Hair |
| Scott Tebeau | Makeup Effects Designer |
| Gary Bowers | Other |
| Cass McClure | Prosthetic Makeup Artist |
| Mike Smithson | Makeup Artist |
| Roy Knyrim | Makeup Supervisor |
