 | Kyle Chandler als Mark Russell |
 | Vera Farmiga als Emma Russell |
 | Millie Bobby Brown als Madison Russell |
 | Ken Watanabe als Dr. Ishiro Serizawa |
 | Zhang Ziyi als Dr. Ilene Chen / Dr. Ling |
 | Bradley Whitford als Dr. Rick Stanton |
 | Sally Hawkins als Dr. Vivienne Graham |
 | Charles Dance als Alan Jonah |
 | Thomas Middleditch als Sam Coleman |
 | Aisha Hinds als Colonel Diane Foster |
 | O'Shea Jackson Jr. als Chief Warrant Officer Barnes |
 | David Strathairn als Admiral William Stenz |
 | Anthony Ramos als Staff Sergeant Martinez |
 | Elizabeth Ludlow als First Lieutenant Griffin |
 | Jonathan Howard als Asher Jonah |
 | CCH Pounder als Senator Williams |
 | Joe Morton als Dr. Houston Brooks |
 | Randy Havens als Dr. Tim Mancini |
 | Lyle Brocato als Executive Officer Bowman |
 | Jimmy Gonzales als Commander Crane |
 | T. C. Matherne als Master Sergeant Hendricks |
 | Kenneth Israel als Argo Deck Officer Zellner |
 | Justice Leak als Monarch Officer Martin |
 | Al Vicente als Isla de Mara Fisherman |
 | Rose Bianco als Isla de Mara Grandmother |
| Gabriel L. Silva als Isla de Mara Grandson |
| Skylar Denney als Argo Officer Arvin |
 | Kelli Garner als Argo Officer Cross |
| Tyler Crumley als Young Andrew |
 | Lexi Rabe als Young Madison |
| Zac Zedalis als Sergeant Travis |
| Tracie Garrison als Asaj |
| Natalie Shaheen als Lieutenant Bottin |
 | Jesse O'Neill als Corporal Winston |
| Joshua Leary als Sergeant Baker |
 | Vince Foster als G-Team Officer Tippett |
 | Shauna Rappold als G-Team Officer Harryhausen |
 | Fiona Hardingham als News Anchor #1 |
| Orelon Sidney als News Anchor #2 |
 | Paul Ryden als News Anchor #3 |
| Laurie Dhue als News Anchor #4 |
 | Kevin Shinick als Weather Man |
| Sarah Finn | Casting |
| Lawrence Sher | Director of Photography |
| Bob Ducsay | Editor |
| Richard L. Johnson | Supervising Art Director |
| Richard Pearson | Editor |
| Louise Mingenbach | Costume Designer |
| Paul Hughen | Second Unit Director of Photography |
| Barry H. Waldman | Unit Production Manager |
| Roger Barton | Editor |
| Scott Chambliss | Production Design |
| Michael Dougherty | Screenplay |
| Michael Dougherty | Director |
| Michael Dougherty | Story |
| Peter Afterman | Music Supervisor |
| Margaret Yen | Music Supervisor |
| Thomas Tull | Producer |
| Bear McCreary | Original Music Composer |
| Jon Jashni | Producer |
| Joel Harlow | Makeup Department Head |
| Alex Garcia | Producer |
| Mary Parent | Producer |
| Serj Tankian | Musician |
| Richard Dorton | Motion Capture Artist |
| Whit Norris | Sound Mixer |
| Brian Rogers | Producer |
| T.J. Storm | Motion Capture Artist |
| Bradley Parker | Visual Effects |
| Stacy Perskie | Co-Producer |
| Max Borenstein | Story |
| Alan Maxson | Motion Capture Artist |
| Brandon Jones | Sound Designer |
| Thomas Robinson Harper | Second Unit Director |
| Nancy Nugent | Supervising Sound Editor |
| Tim Walston | Sound Designer |
| Tom Ozanich | Sound Re-Recording Mixer |
| Erik Aadahl | Sound Designer |
| Ethan van der Ryn | Sound Designer |
| Tim LeBlanc | Sound Re-Recording Mixer |
| Amanda Moss Serino | Set Decoration |
| Yolanda Toussieng | Hair Department Head |
| Jason W. Jennings | Supervising Sound Editor |
| Daniel C. McFadden | Still Photographer |
| Guillaume Rocheron | Visual Effects Supervisor |
| Zach Shields | Screenplay |
| Zach Shields | Story |
| Dean Sherriff | Conceptual Design |
| Lee Ann Brittenham | Hair Department Head |
| Maricel Pagulayan | Co-Producer |
| Adam Walls | Makeup Department Head |
| John Hewitt | Visual Effects |
| Cliff Lanning | Co-Producer |
| Daniela Medeiros | Set Designer |
| Ali Mendes | Co-Producer |
| Jason Liles | Motion Capture Artist |
| Santiago Núñez | Sound Mixer |
| Rodney Gurulé | Sound Mixer |
