 | Sarah Polley als Harper Sloane |
 | Stephen Rea als Connie Fitzpatrick |
 | Jean Smart als Deborah Sloane |
 | Gina Gershon als Billie |
 | Paul Dooley als Walter |
 | Carrie Preston als Patty |
 | Tracy Letts als Zack |
 | Emily Procter als Susan Sloane |
 | Sharon McNight als Leslie |
 | Gedde Watanabe als Ed |
 | Carlton Wilborn als Jay |
 | Sandra Oh als Cindy |
 | Francis Guinan als Alan Sloane |
| Oded Gross als Gary |
| Grace Una als April |
 | Jasmine Guy als Linda |
| Danny Kovacs als Cop |
 | Brian Frank als Wedding Guest #1 |
| Debra Engle als Wedding Guest #2 |
| Johnny Radzik als Espresso Guy |
| Paulina Sahagan als Mexican Seamstress |
 | Lynne Marie Stewart als Nurse |
| Kai Ephron als Positano's Regular |
 | Alexandra Holden als Angelic Girl |
| Patti Weiss als Tipsy Woman at Party |
 | James Noah als Older Man in Café |
 | Lindsay Beamish als Younger Woman in Café |
| Rose Mallett als Birthday Singer |
| Lynn Beasley als Sexy Bridesmaid |
| Scott Kaske als Transsexual Babe |
 | J. Trevor Edmond als Jeremy (uncredited) |
 | Kevin Brief als Dentist (uncredited) |
| Cathy Carlson als Party Guest (uncredited) |
| Martin Yu als Boyfriend (uncredited) |
| Brad Weston | Producer |
| Audrey Wells | Writer |
| Jonathan King | Producer |
| Danielle Berman | Set Decoration |
| Audrey Wells | Director |
| Dody Dorn | Editor |
| Christophe Beck | Original Music Composer |
| Stephen McCabe | Production Design |
| John Brace | Casting |
| Charles Minsky | Director of Photography |
| Linda Lowy | Casting |
| Genevieve Tyrrell | Costume Design |
| Harvey Weinstein | Executive Producer |
| Danny Dimbort | Executive Producer |
| John Thompson | Executive Producer |
| Barklie K. Griggs | Music Supervisor |
| Charles Minsky | Still Photographer |
| Tony Jenkins | Sound Re-Recording Mixer |
| Beau Flynn | Executive Producer |
| Stefan Simchowitz | Executive Producer |
| Tyler Bensinger | Still Photographer |
| Kira Roessler | Dialogue Editor |
| Richard Partlow | Foley Artist |
| Bryan Franklin | Supervising Sound Editor |
| William A. Benedict | Transportation Captain |
| Boaz Davidson | Executive Producer |
| Tani Cohen | Line Producer |
| Jason De Bari | Art Department Coordinator |
| Paul Ratajczak | Sound Re-Recording Mixer |
| Jeffrey M. O'Brien | Property Master |
| Corey Askins | Transportation Coordinator |
| Avi Lerner | Executive Producer |
| Jim LaClair | First Assistant Director |
| Chris Kinsman | Music Coordinator |
| Bennie McRae | Boom Operator |
| Dody Dorn | Associate Producer |
| Randi Feldman | Script Supervisor |
| Trevor Short | Executive Producer |
| Todd Gilbert | Associate Producer |
| Lenise Bent | Foley Mixer |
| Gregory W. Smith | Steadicam Operator |
| Ryan Davidson | ADR Editor |
| Jonathan Wales | Sound Re-Recording Mixer |
| Heidi Higginbotham | Wardrobe Supervisor |
| Mikael Sandgren | Music Editor |
| Kim Bartlein | ADR Editor |
| Monette Holderer | Foley Artist |
| Jennifer Perkins | Gaffer |
| Bob Weinstein | Executive Producer |
