 | Freddie Prinze Jr. als Pi (voice) |
 | Rob Schneider als Nerissa (voice) |
 | Evan Rachel Wood als Cordelia (voice) |
 | Donal Logue als Troy (voice) |
 | Andy Dick als Dylan / Curious Shark (voice) |
 | Fran Drescher als Pearl (voice) |
 | John Rhys-Davies als Thorton (voice) |
 | R. Lee Ermey als Jack (voice) |
 | Dylan Cash als Young Percy (voice) |
 | Bruno Alexander als Pi's Dad (voice) |
 | David Fickas als Max / Squid No. 3 / Big Shark (voice) |
 | Jimmy Bennett als Young Pi (voice) |
 | Megahn Perry als Percy's Mum / Female Parrotfish (voice) |
 | Mel Rodriguez als Manny / Dr. Tang (voice) |
| Reedy Gibbs als Pi's Mom (voice) |
 | Richard Epcar als Moe (voice) |
 | Trent Ford als Percy (voice) |
| Scott Clevenger | Screenplay |
| Timothy Wayne Peternel | Story |
| Chris Denk | Story |
| Howard E. Baker | Director |
| Anurag Mehta | Story |
| John Fox | Director |
| Kyung Ho Lee | Director |
| Caitlin McKenna | ADR Voice Casting |
| Vanessa Baker | ADR Voice Casting |
| Shannon Makhanian | Casting |
| Morris Berger | Executive Producer |
| Stephen R. Brown | Executive Producer |
| Mark A.Z. Dippé | Producer |
| Janet Healy | Executive Producer |
| Grant Hill | Producer |
| David Hillary | Co-Producer |
| John W. Hyde | Executive Producer |
| Youngki Lee | Producer |
| Lorne Orleans | Producer |
| Timothy Wayne Peternel | Co-Producer |
| Ash R. Shah | Producer |
| Sundip R. Shah | Executive Producer |
| Joel Silver | Producer |
| Lana Wachowski | Producer |
| Lilly Wachowski | Producer |
| Ben Waisbren | Executive Producer |
| Alex J. Yoo | Executive Producer |
| Paul Buckley | Original Music Composer |
| Christopher Lennertz | Original Music Composer |
| Jan Carlee | Director of Photography |
| Andy Wang | Director of Photography |
| John Damien Ryan | Editor |
| Tom Sanders | Editor |
| Deane Taylor | Production Design |
| Kyran Kelly | Art Direction |
| Lee Jun-ho | Art Direction |
| Jeong Yeong-hun | Art Direction |
| Mark DeSimone | ADR Mixer |
| Peter Burgis | Foley Artist |
| Andie Derrick | Foley Artist |
| Nicolas Becker | Foley Artist |
| John Roesch | Foley Artist |
| Jeffrey Perkins | Sound Re-Recording Mixer |
| Eric Justen | Sound Re-Recording Mixer |
| John Marquis | Sound Designer |
| Nigel Heath | Foley Mixer |
| Paul Hackner | Dialogue Editor |
