 | Ron Perlman als Hellboy |
 | Selma Blair als Elizabeth 'Liz' Sherman |
 | Doug Jones als Abraham 'Abe' Sapien |
 | John Hurt als Prof. Trevor 'Broom' Bruttenholm |
 | Rupert Evans als John Myers |
 | Jeffrey Tambor als Tom Manning |
 | Ladislav Beran als Karl Ruprecht Kroenen |
 | Bridget Hodson als Ilsa Haupstein |
 | Karel Roden als Grigori Rasputin |
 | Brian Steele als Sammael |
 | Corey Johnson als Agent Clay |
 | Kevin Trainor als Young 'Broom' |
 | Brian Caspe als Agent Lime |
 | James Babson als Agent Moss |
 | Stephen Fisher als Agent Quarry |
 | Garth Cooper als Agent Stone |
 | Angus MacInnes als Sgt. Whitman |
 | Jim Howick als Cpl. Matlin |
| Mark Taylor als Truck Driver |
| Daniel Aarsman als Kid |
| Bettina Ask als Kid |
 | Álvaro Navarro als Kid |
| Emilio Navarro als Kid |
 | Rory Copus als Kid on Rooftop |
 | Tara Hugo als Doctor Jenkins |
| Richard Haas als Second Doctor |
 | Andrea Miltner als Doctor Marsh |
| Jo Eastwood als Down's Patient |
| Charles Grisham als Museum Guard |
| Jan Holíček als Museum Guard |
| Jeremy Zimmermann als Lobby Guard |
| Monty L. Simons als Orderly |
 | Pavel Cajzl als Sherpa Guide |
| Andrea Stuart als Girl with Kittens |
 | William Hoyland als General Klaus Werner von Krupt |
| Millie Wilkie als Young Liz |
| Bob Sherman als Television Host |
| Ellen Savaria als Blonde Television Reporter |
| Petr Sekanina als German Scientist |
| Aleš Košnar als German Scientist |
 | Justin Svoboda als Young Guy |
 | Winter Ave Zoli als Girlfriend |
 | Santiago Segura als Train Driver |
| Albert Moy als Train Driver |
 | David Hyde Pierce als Abe Sapien (voice) (uncredited) |
 | Helene Maksoud als Liz Sherman's Mother (uncredited) |
 | Guillermo del Toro als Guy Dressed as Dragon (uncredited) |
 | Mike Mignola als Knight (uncredited) |
| Miroslav Lhotka als Museum Guard (uncredited) |
| Michael Lindsay als Security Guard (voice) (uncredited) |
| Todd Kramer als Radioman (uncredited) |
| Mike Richardson | Producer |
| Peter Amundson | Editor |
| Marco Beltrami | Original Music Composer |
| Guillermo del Toro | Director |
| Guillermo Navarro | Director of Photography |
| Guillermo del Toro | Screenplay |
| Mike Mignola | Comic Book |
| Lawrence Gordon | Producer |
| Jeremy Zimmermann | Casting |
| Wendy Partridge | Costume Design |
| Chuck Duke | Animation |
| Peter Briggs | Screenstory |
| Patrick J. Palmer | Executive Producer |
| Lloyd Levin | Producer |
| Mike Mignola | Co-Executive Producer |
| James Hambidge | Art Direction |
| Deborah Jarvis | Makeup Artist |
| John Teska | Digital Effects Supervisor |
| Jakub Kadlec | Transportation Captain |
| Simon Lamont | Supervising Art Director |
| Hilton Rosemarin | Set Decoration |
| Kevin Baillie | CG Supervisor |
| Andrew Havelberg | Post Production Assistant |
| Kriz David | Electrician |
| Peter Afterman | Music Supervisor |
| Frank E. Eulner | Supervising Sound Editor |
| Martin Grošup | Camera Operator |
| Inka Bratková | Costume Supervisor |
| Lancel Reyes | Prosthetic Supervisor |
| Ericka Bryce | Set Medic |
| Perry M. Kimura | Digital Intermediate |
| Natalie Baillie | Digital Compositors |
| Mirka Janatova | Unit Manager |
| Stephen Scott | Production Design |
| Marco Bittner Rosser | Art Direction |
| Simon Wakefield | Set Decoration |
| Rick Stribling | Grip |
| Kevin Lin | Quality Control Supervisor |
| Václav Čermák | Gaffer |
| Steve Boeddeker | Sound Designer |
| Lenka Rock | Art Department Coordinator |
| Jaromír Šedina | Steadicam Operator |
| Shadi Almassizadeh | Sequence Supervisor |
| Ilt Jones | Location Manager |
| Stuart Kearns | Assistant Art Director |
| Jon Baker | Armorer |
| Petr Keller | Executive In Charge Of Production |
| Yasushi Nirasawa | Conceptual Design |
| Gary Gillingham | Production Controller |
| Marianna Krenova | Stand In |
| Velvy Appleton | Visual Effects Producer |
| Jordu Schell | Sculptor |
| Tony Magaletta | First Assistant Camera |
| Tomas Hais | Set Dressing Artist |
| Buck Sanders | Additional Music |
| Jim Conrads | Post Production Supervisor |
| Stephan O. Gessler | Set Designer |
| Michal Krbeček | Loader |
| Pavel Bezděk | Stunts |
| Vaclav Mottl | Transportation Coordinator |
| Gene Warren III | Production Design |
| Georgina Abanto | Hairstylist |
| Javier Soto | Documentation & Support |
| John Kurlander | Scoring Mixer |
| Egon Endrényi | Still Photographer |
| Matt Rose | Makeup Designer |
| Pavel Cajzl | Stunt Coordinator |
| J. Michael Haynie | Assistant Director |
| Peter Francis | Art Direction |
| Lori Wyant | Script Supervisor |
| Jiri Tichacek | Production Accountant |
| Juan Bronson | Production Coordinator |
| Tony Mederos | Sound Editor |
| Mauricio Baiocchi | Animation Supervisor |
| Kenneth Bailey | Visual Effects |
| Gene Radzik | Dolby Consultant |
| Nathan Abbot | I/O Supervisor |
| Petr Skvor | Location Scout |
| John J. Moers | Additional Camera |
| Tony Vizina | Driver |
| Norman Cabrera | Makeup Effects |
| Rick Polikowski | Propmaker |
| Michal Chadima | Video Assist Operator |
| Joseph Carson | Visual Effects Editor |
| Lisa Chino | First Assistant Sound Editor |
| Moira Houlihan | Publicist |
| Peter Eusebe | Boom Operator |
| Pete Anthony | Orchestrator |
| Nick Allder | Special Effects Supervisor |
| Everett Burrell | Visual Effects Supervisor |
| Mark Holding | Sound Mixer |
| Laura Rindner | First Assistant Editor |
| Andrea Clark | Casting Associate |
| Michael T. Andreas | Music Editor |
| Larisa Šrámková | Seamstress |
| Patrick J. Palmer | Unit Production Manager |
| Jaroslav Dvorák | Editorial Production Assistant |
| Dean Brkic | Rigging Gaffer |
| Alan Collis | Production Manager |
| Michael Axinn | Foley |
| Shannon Mills | Sound Effects Editor |
| Guy Hauldren | 3D Supervisor |
| Marc Sadeghi | Executive Visual Effects Producer |
| Ilt Jones | Production Supervisor |
| Sean Hoessli | Visual Effects Supervisor |
| Brian Morishita | Machinist |
| Mike Mignola | Creator |
| Mike Mignola | Writer |
| Mark Taylor | Second Assistant Director |
| Juan Peralta | Sound Mix Technician |
| Elliot Scott | Art Department Trainee |
| Colleen Bryant | Tailor |
| Richard Goodwin | Third Assistant Director |
| Paul Prischman | Storyboard Artist |
| Christopher Gwynne | Visual Effects Technical Director |
| Richard Dastych | Additional Grip |
| Jakub Vajner | Camera Trainee |
| Deborah Thomas | Data Wrangler |
| Michael Healey | Digital Colorist |
| Justin Reeve | Music Coordinator |
| Robert Hutchins | Pyrotechnician |
| Jon Jung | Assistant Camera |
| Tamaron Greene | Assistant Editor |
| Mike Elizalde | Makeup Supervisor |
| Jessica Bellfort | Assistant Dialogue Editor |
| Gary Burritt | Negative Cutter |
| Mike Woodley | Aerial Coordinator |
| Rob Meisenholder | First Assistant Accountant |
| David Ebner | Production Executive |
| Adam Aldridge | Special Effects Technician |
| Brett-Patrick Jenkins | Assistant Makeup Artist |
| Karin Fong | Title Designer |
| Carl Beyer | Visual Effects Production Manager |
| Tim Dobbert | Matchmove Supervisor |
| Kirstin Bradfield | Rotoscoping Artist |
| Heather Moore | Key Costumer |
| Jana Lynn Gold | Associate Editor |
| Nancy Bishop | Location Casting |
| Karolina Cerna | Assistant Accountant |
| Michael Eaves | Digital Intermediate Colorist |
| Andrew Booth | Creative Director |
| Matthew Johnson | Special Effects Assistant |
| Christian Haley | Matte Painter |
| Martin Lonek | Utility Sound |
| Brano Danis | Colorist |
| Pete Anthony | Conductor |
| Ladislav Beran | Fight Choreographer |
| Burk Sauls | Special Props |
| Michael Silvers | ADR Editor |
| Weldon Brown | ADR Mixer |
| Lorene Simpson | Digital Intermediate Producer |
| Damiana Kamishin | Assistant Production Coordinator |
| Ellen Heuer | Foley Artist |
| Daryl Lathrop | ADR Recordist |
| Dan Balzer | Second Assistant Camera |
| Adam Fuchs | Assistant Location Manager |
| Ota Bares | Animal Coordinator |
| Jance Allen | Compositing Supervisor |
| Sarka Kindlova | Payroll Accountant |
| Olina Norkova | Contact Lens Technician |
| Simon Webber | Prosthetic Makeup Artist |
| Travis Crenshaw | Foley Recordist |
| Ramjasha Rhodes | Visual Effects Production Assistant |
| Jan Strašík | Assistant Unit Manager |
| Guy Bradley | Draughtsman |
| Frank 'Pepe' Merel | Foley Mixer |
| Radost Yonkova Ridlen | Visual Effects Compositor |
| Curtis Lindersmith | Digital Intermediate Editor |
| Ki Jong Hong | Creature Technical Director |
| Sandra Butterworth | Dialogue Coach |
| Alonzo Ruvalcaba | Head of Production |
| Peter Briggs | Writer |
| Todd Bryant | Stunt Double |
| Richard Quinn | Dialogue Editor |
| Andy Howard | Second Second Assistant Director |
| Kamila Zenkerová | Stunts |
| Tomáš Tobola | Stunts |
| Tom Elliott | Fight Choreographer |
| Guillermo del Toro | Fight Choreographer |
| Jan Petřina | Stunt Double |
| Tomáš Peteráč | Stunts |
| Klara Slavikova | Stunts |
| David Lištván | Stunts |
| Zuzana Drdacka | Stunts |
| Ivan Mareš | Stunts |
| Jan Loukota | Stunts |
| Jimmy Hart | Stunt Double |
| Petr Bozdech | Stunt Double |
| David Mottl | Stunts |
| Lou Horvath | Stunts |
| Rene Hajek | Stunts |
| Hana Dvorská | Stunts |
| Jiri Simberský | Stunts |
| Darrell Davis | Stunts |
| Monty L. Simons | Stunt Coordinator |
| Jiri First | Stunts |
| Grant Fletcher | Stunts |
| Zdeněk Dvořáček | Stunts |
| Marc Gabbana | Concept Artist |
| John T. Sweeney | Production Coordinator |
| Jeff Miller | Production Assistant |
| John Karner | VFX Artist |
| David R. Morton | VFX Artist |
| Wayne D. Barlowe | Creature Design |
| Frédéric Le Louet | Sound Recordist |
| Jeff Ward | Fight Choreographer |
| Michael Lindsay | Property Master |
