 | Will Smith als Robert Neville |
 | Alice Braga als Anna Montez |
 | Charlie Tahan als Ethan |
 | Dash Mihok als Alpha Male |
 | Salli Richardson-Whitfield als Zoe Neville |
 | Willow Smith als Marley Neville |
 | Emma Thompson als Dr. Alice Krippin |
 | Darrell Foster als Mike - Military Escort |
 | Joanna Numata als Alpha Female |
 | Samuel Glen als Military Driver - Jay |
| Pedro Mojica als Sergeant |
 | Marin Ireland als Woman Evacuee |
 | Alexander DiPersia als Male Evacuee |
 | Raul Torres als Male Evacuee (uncredited) |
 | April Grace als TV Personality |
 | James McCauley als Male Evacuee |
| Anthony C. Mazza als Evacuation Cop |
| Steve Cirbus als Military Police |
| Calista Hill als Little Girl Evacuee |
| Gabriella Hill als Little Girl Evacuee |
| Madeline Hill als Little Girl Evacuee |
| Adhi Sharma als Military Scanning Tech |
| Tyree Michael Simpson als Evacuation Cop #2 |
| Blake Lange als Coast Guard Ground Crew |
| Abraham Sparrow als Male Evacuee #3 |
 | Pat Fraley als President (voice) |
 | Caitlin McHugh als Special Blond Model |
| Deborah Collins als Civilian |
 | Mike Patton als Creatures (voice) |
| Katherine Brook als Infected |
 | Vince Cupone als Infected |
| Lynna Davis als Infected |
| Anika Ellis als Infected |
 | John Grady als Infected |
| Moses Harris Jr. als Infected |
| Kennis Hawkins als Infected |
 | Marc Inniss als Infected |
| Eric Jenkins als Infected |
| Reed Kelly als Infected |
| Grasan Kingsberry als Infected |
| Drew Leary als Infected |
| Asa Liebmann als Infected |
| Deborah Lohse als Infected |
| Jon-Paul Mateo als Infected |
| Ian Mclaughlin als Infected |
| Luke Miller als Infected |
 | Courtney Munch als Infected |
 | Kimberly Shannon Murphy als Infected |
 | Okwui Okpokwasili als Infected |
| Erin Owen als Infected |
 | Victor Paguia als Infected |
 | Paradox Pollack als Infected |
| Will Rawls als Infected |
| William Schultz als Infected |
| Hollie K. Seidel als Infected |
| Hannah Sim als Infected |
| Eric Spear als Infected |
 | Mark Steger als Infected |
| Charlie Sutton als Infected |
| David Hamilton Thomson als Infected |
| Anthony Vincent als Infected |
| Greg Wattkis als Infected |
| Naomi Shohan | Production Design |
| Michael Kaplan | Costume Design |
| James Newton Howard | Original Music Composer |
| Bruce Berman | Executive Producer |
| Andrew Lesnie | Director of Photography |
| Akiva Goldsman | Screenplay |
| Akiva Goldsman | Producer |
| Mark Protosevich | Screenplay |
| Francis Lawrence | Director |
| Erwin Stoff | Executive Producer |
| Wayne Wahrman | Editor |
| William Ladd Skinner | Art Direction |
| Howard Cummings | Art Direction |
| David Heyman | Producer |
| Neal H. Moritz | Producer |
| Richard Matheson | Screenplay |
| Vic Armstrong | Stunt Coordinator |
| Michael Tadross | Executive Producer |
| George DeTitta Jr. | Set Decoration |
| Barbra Matis | Assistant Art Director |
| Dana Goldberg | Executive Producer |
| Patricia Woodbridge | Art Direction |
| James Lassiter | Producer |
| Kathleen Chopin | Casting |
| Tracy Tormé | Co-Producer |
| Caitlin McKenna | ADR Voice Casting |
| Chris Bacon | Conductor |
| Tom Weston | Camera Operator |
| Blaise Corrigan | Stunts |
| Peter Epstein | Stunts |
| Christopher Place | Stunts |
| John Cenatiempo | Stunts |
| Paul Sinor | Thanks |
| Barbara Harris | ADR Voice Casting |
| Ed Natividad | Conceptual Design |
| Jeffrey Wetzel | Co-Producer |
| Jeffrey Wetzel | First Assistant Director |
| Michael Tadross Jr. | Additional Second Assistant Director |
| Armen Ksajikian | Musician |
| David S. Lomax | Stunts |
| Amiee Clark | Art Department Coordinator |
| Marian Toy | Assistant Costume Designer |
| Jared Burke | Stunts |
| Lee Wimer | Color Timer |
| Peter Baran | Assistant Art Director |
| Jeff Julian | Conceptual Design |
| Ryan Muir | Additional Production Assistant |
| Bruce MacCallum | "A" Camera Operator |
| Michael Jortner | Assistant Property Master |
| Bill Almeida | Best Boy Electric |
| Hans Bjerno | Aerial Director of Photography |
| Malchus Janocko | Assistant Art Director |
| Damon Michael Gordon | Assistant Location Manager |
| Janek Sirrs | Visual Effects Supervisor |
| Benjamin Semanoff | Camera Operator |
| Leslie Yarmo | Assistant Costume Designer |
| Lukasz Jogalla | Camera Operator |
| Daniel Perez Ferreira | Visual Effects Technical Director |
| David J. Thompson | Steadicam Operator |
| David J. Thompson | "B" Camera Operator |
| Jerad Marantz | Character Designer |
| Brant S. Fagan | Steadicam Operator |
| Brant S. Fagan | "B" Camera Operator |
| Yueni Zander | Camera Loader |
| Dougg Williams | Animation |
| Brooks P. Guyer | Camera Operator |
| Jill Brown | Stunts |
| Jeff Croke | Animation |
| Josh LaBrot | Animation |
| Sebastian Kapijimpanga | Animation |
| Sandra Ryan-Moran | Animation |
| John Wong | Animation |
| Gavin Moran | Animation |
| John Billeci | Best Boy Electric |
| Michael Kall | Carpenter |
| David Neumann | Choreographer |
| Elizabeth Shelton | Assistant Costume Designer |
| Pete Anthony | Orchestrator |
| Pete Anthony | Conductor |
| William Cote | Stunts |
| Shawnna Thibodeau | Stunts |
| Caroline Vexler | Stunts |
| Gabriel Hansen | Stunts |
| Scott Holmes | Animation |
| Mohamed Khan | Production Coordinator |
| Kevin Flatow | Assistant Production Manager |
| Grant Gershon | Conductor |
| Adam Baer | Assistant Location Manager |
| Ron Smith | Animation |
| Bob Colletti | Stunts |
| Ralph Saunders | Actor's Assistant |
| Lufeng Qu | Concept Artist |
| Steve Berens | Animal Coordinator |
| Mark Chadwick | Stunts |
| Thomas Place | Stunts |
| Mark Fitzgibbons | Assistant Art Director |
| Ryan Page | Animation |
| Brian D. Scott | Animation |
| Joshua Beveridge | Animation |
| Dan Kuchar | Assistant Art Director |
| Carla Lewis | ADR Voice Casting |
| Jacq Donegan | Assistant Production Coordinator |
| Dan Cooley | Assistant Location Manager |
| Lance Mayer | Assistant Camera |
| Aaron Sims | Concept Artist |
| Kimberly Shannon Murphy | Stunts |
| Edward J. Johnson | Carpenter |
| Eve Strickman | Camera Production Assistant |
| Philip M. Strub | Thanks |
| Keith Bunting | Dolly Grip |
| Dennis Green | 24 Frame Playback |
| Carlos Constanzo | Actor's Assistant |
| Day Ryan | Actor's Assistant |
| Chris Kocses | Additional Production Assistant |
| Lora Sorrentino | Additional Production Assistant |
| Shannon Cooney | Additional Production Assistant |
| Ed Nessen | Additional Second Assistant Camera |
| Susan R. Hanson | Animal Wrangler |
| Jacob Patrick | Animation |
| Michael Riolo | Art Department Production Assistant |
| Eric P. Robinson | Assistant Camera |
| Gregg de Domenico | Assistant Camera |
| Julian J. Delacruz | Assistant Camera |
| Graham Goetz | Assistant Location Manager |
| Joshua Shull | Assistant Location Manager |
| Tim Stacker | Assistant Location Manager |
| Cristina Lois | Assistant Production Coordinator |
| Tonero Williams | Assistant Property Master |
| Elizabeth Singer | Camera Loader |
| Craig Pecchia | Camera Production Assistant |
| John S. Coda | Carpenter |
| Yosef Barbalat | Carpenter |
| Matthew Honovic | Casting Assistant |
| Sam Daley | Colorist |
| Brianna Patterson | Costume Assistant |
| Tina Mckissick | Stunts |
| Joseph S. Alfieri | Construction Coordinator |
| Tom Brown | Music Arranger |
