 | Ray Romano als Manny (voice) |
 | John Leguizamo als Sid (voice) |
 | Denis Leary als Diego (voice) |
 | Goran Visnjic als Soto (voice) |
 | Jack Black als Zeke (voice) |
 | Cedric the Entertainer als Carl (voice) |
 | Stephen Root als Frank / Start (voice) |
 | Diedrich Bader als Oscar (voice) |
 | Alan Tudyk als Lenny / Oscar / Dab (voice) |
 | Lorri Bagley als Jennifer (voice) |
 | Jane Krakowski als Rachel (voice) |
 | Peter Ackerman als Dodo / Macrauchenia (voice) |
| P.J. Benjamin als Dodo (voice) |
 | Josh Hamilton als Dodo / Aardvark (voice) |
 | Chris Wedge als Dodo / Scrat (voice) |
 | Denny Dillon als Glyptodon (voice) |
 | Mitzi McCall als Glyptodont (voice) |
 | Tara Strong als Baby Moeritherium (voice) |
 | Darin De Paul als Additional Voices (voice) (uncredited) |
 | Dann Fink als Dodo (voice) (uncredited) |
 | Patrick Pinney als Various Mammals (uncredited) |
 | Phil Proctor als Various Mammals (uncredited) |
| Lori Forte | Producer |
| Chris Meledandri | Executive Producer |
| Chris Wedge | Director |
| Peter Ackerman | Screenplay |
| Michael J. Wilson | Screenplay |
| John Carnochan | Editor |
| David Newman | Original Music Composer |
| Michael Berg | Screenplay |
| Carlos Saldanha | Co-Director |
| Albert Gasser | ADR Editor |
| John C. Donkin | Associate Producer |
| Galen T. Chu | Animation |
| Galen T. Chu | Additional Writing |
| Jeff Siergey | Additional Writing |
| Rafael Castelblanco | Lighting Technician |
| Michael Feder | Production Supervisor |
| Craig Berkey | Sound Effects Editor |
| Buck Lewis | Visual Development |
| Paul Ohrt | Production Accountant |
| Sean Garnhart | Supervising Sound Editor |
| Anthony L. Jamison | First Assistant Editor |
| Brian McEntee | Production Design |
| Bill Talbott | Sound Engineer |
| Xeth Feinberg | Additional Writing |
| Richard Hadsell | Researcher |
| Bill Orrico | First Assistant Sound Editor |
| Mike Thurmeier | Additional Writing |
| Jack Ham | Systems Administrators & Support |
| Meg Morman | Casting Associate |
| José Antonio Macías | Translator |
| James Bresnahan | Additional Writing |
| Daniel Barlow | Layout |
| Maria Criscuolo | Production Manager |
| Michael J. Wilson | Story |
| Justin Skomarovsky | Additional Music |
| Richard A. Harrison | Music Editor |
| Mike Defeo | Modeling |
| John Kurlander | Scoring Mixer |
| Jim Passon | Color Timer |
| Kendall McCarthy | Post Production Supervisor |
| Chris Kuwata | Production Coordinator |
| Jason Galeon | Digital Compositors |
| Doug Compton | Additional Writing |
| Clifford Bohm | Sequence Supervisor |
| Gregory Jamrok | Orchestrator |
| Sean Garnhart | Sound Designer |
| Philip A. Cruden | Background Designer |
| Tim Nordquist | Associate Editor |
| Frank Kern | Foley Editor |
| James Bresnahan | Lead Animator |
| Marcie Matsui | Set Dresser |
| Gary Burritt | Negative Cutter |
| Nico Abondolo | Musician |
| Billy Foster | Assistant Production Manager |
| Mark Richelo | Apprentice Sound Editor |
| Kevin Thomason | Lighting Technician |
| Haji Uesato | Lighting Technician |
| Irka B. Seng-Bloom | Assistant Production Manager |
| Laura V. Perrotta | Assistant Production Manager |
| Paul Urmson | Sound Effects Editor |
| Jenifer Lee Gilchrist | Lighting Technician |
| Zach Schläppi | Lighting Technician |
| Rebecca R. Liddle | Orchestrator |
| Peter DeSève | Character Designer |
| Jaime Castañeda | Animation |
| David Tesch | Software Engineer |
| Alexander Gradet | Editorial Production Assistant |
| James Gettinger | Lighting Technician |
| Lisa Kalmanson | Lighting Technician |
| Kirk Garfield | Visual Effects Technical Director |
| Hugh Hitchens | Assistant Production Manager |
| Dan Whiting | Animation |
| Joshua Winget | Temp Music Editor |
| Amy Ning | Additional Effects Development |
| Aaron Hartline | Animation |
| Dave Walvoord | Supervising Technical Director |
| Jenga Zamani Mwendo | Modeling |
| Samantha Berg | Assistant Production Manager |
| Nina Bafaro | Animation |
| Dan Madden | Assistant Editor |
| David Torres | Animation |
| Vanessa M. Ross | Lighting Coordinator |
| Inkyong Irene Kim | Lighting Technician |
| Leslie Schor-Bresnahan | Assistant Production Manager |
| Alexander Levenson | Additional Effects Development |
| Will Shefelman | Additional Effects Development |
| Floyd Bishop Jr. | Animation |
| Andreas Procopiou | Animation |
| Mika Ripatti | Animation |
| Dean Lennert | Animation |
| Paul Massey | Sound Re-Recording Mixer |
| John Paine | Modeling |
| Anthony Nisi | Assistant Production Manager |
| Nicholas Renbeck | ADR Editor |
| Kompin Kemgumnird | Animation |
| Simi Nallaseth | Animation |
| Dennis Rogers | Sound Recordist |
| Lewis Goldstein | Sound Effects Editor |
| John K. Dodelson | Modeling |
| Kristi Hansen Walvoord | Lighting Technician |
| Mary Grandpré | Additional Effects Development |
| Marissa Littlefield | ADR Editor |
| Christopher M. Burrows | Visual Effects Technical Director |
| Deanna Pizzuti | Editorial Coordinator |
| Keith Cormier | Lighting Technician |
| Melvin Ortiz | Systems Administrators & Support |
| Joshua West | Animation |
| Alexander Levenson | Modeling |
| Bruce Winant | ADR Voice Casting |
| Rodrigo Blaas | Animation |
| Dana O'Connor | Animation |
| Scott Robideau | Animation |
| David B. Vallone | Animation |
| Doug Hemphill | Sound Re-Recording Mixer |
| Ken Lee | Modeling |
| James Palumbo | Assistant Editor |
| Tom Bisogno | Animation |
| Nick Craven | Animation |
| Marcelo Fernandes De Moura | Animation |
| Wooksang Chang | Lighting Technician |
| Fran Roberts | Lighting Technician |
| Tom Bisogno | CG Animator |
| Kelly Kimball | Additional Effects Development |
| Rachel Tiep-Daniels | Modeling |
| Bryan Godwin | Lighting Technician |
| Vinh Truong | Additional Effects Development |
| David J. Smith | Animation |
| James Hundertmark | Animation |
| Frank Denota | Modeling |
| Sandra Singler | Lighting Technician |
| Thomas Bisogno | Animation |
| Jeffrey Joe | Animation |
| Lauren Prince | Assistant Production Manager |
| Roburta Burroughs | Assistant Production Manager |
| Shannon Carey | Assistant Editor |
| Kenton Jakub | ADR Editor |
| Leslie Schor-Bresnahan | Animation Supervisor |
| Everett Downing Jr. | Animation |
| Tim Gomillion | Sound Recordist |
| Moroni Taylor | Storyboard Artist |
| Kevin O'Brien | Storyboard Artist |
| George A. Lara | Foley Mixer |
| Daisuke Tsutsumi | Matte Painter |
| Stephanie Swengel | Production Executive |
| Derek Casari | ADR Engineer |
| Shayna Brown | ADR Recordist |
| Yvette Kaplan | Head of Story |
| Enrico Casarosa | Storyboard Artist |
| David Newman | Conductor |
| David Silverman | Story Consultant |
| Sharon Mancuso | Production Assistant |
| Marko Costanzo | Foley Artist |
| Alan Filderman | Additional Casting |
| Mark Nakamine | Colorist |
