 | Ray Romano als Manny (voice) |
 | John Leguizamo als Sid (voice) |
 | Denis Leary als Diego (voice) |
 | Queen Latifah als Ellie (voice) |
 | Seann William Scott als Crash (voice) |
 | Josh Peck als Eddie (voice) |
 | Simon Pegg als Buck (voice) |
 | Keke Palmer als Peaches (voice) |
 | Jennifer Lopez als Shira (voice) |
 | Neil deGrasse Tyson als Neil deBuck Weasel (voice) |
 | Jesse Tyler Ferguson als Shangri Llama (voice) |
 | Jessie J als Brooke (voice) |
 | Adam Devine als Julian (voice) |
 | Wanda Sykes als Granny (voice) |
 | Melissa Rauch als Francine (voice) |
 | Michael Strahan als Teddy (voice) |
 | Nick Offerman als Gavin (voice) |
 | Max Greenfield als Roger (voice) |
 | Lilly Singh als Bubbles and Misty (voice) |
 | Chris Wedge als Scrat (voice) |
 | Stephanie Beatriz als Gertie (voice) |
 | Robert Cardone als Freaky Bobby (voice) |
 | Byron Thames als Additional Voices (voice) |
 | Rif Hutton als Additional Voices (voice) |
| Chris Campbell als Additional Voices (voice) |
 | Holly Dorff als Additional Voices (voice) |
 | Moosie Drier als Additional Voices (voice) |
| Jason Fricchione als Additional Voices (voice) |
 | Jackie Gonneau als Additional Voices (voice) |
 | Hope Levy als Additional Voices (voice) |
| Terence Mathews als Additional Voices (voice) |
 | Edie Mirman als Additional Voices (voice) |
 | Juan Pope als Additional Voices (voice) |
 | Ruth Zalduondo als Additional Voices (voice) |
 | David Zyler als Additional Voices (voice) |
 | Ashley Peldon als Additional Voices (voice) |
 | Carlos Ponce als Mariachi Beaver (voice) |
| Mike Thurmeier | Director |
| Kevin Kaska | Orchestrator |
| Lori Forte | Producer |
| Moroni Taylor | Storyboard Artist |
| Michael Tanzillo | Visual Effects |
| Paul Downs | Animation |
| Galen T. Chu | Co-Director |
| Michael J. Wilson | Screenplay |
| Michael Berg | Screenplay |
| Yoni Brenner | Screenplay |
| Aubrey Solomon | Story |
| Denise L. Rottina | Associate Producer |
| Carlos Saldanha | Executive Producer |
| Chris Wedge | Executive Producer |
| Renato Falcão | Director of Photography |
| John Debney | Original Music Composer |
| Erin Crackel | Editor |
| James Palumbo | Editor |
| Randy Thom | Sound Designer |
| Randy Thom | Supervising Sound Editor |
| Michael Silvers | Supervising Sound Editor |
| Jeremy Bowker | Sound Designer |
| Randy Thom | Sound Re-Recording Mixer |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Leff Lefferts | Additional Sound Re-Recording Mixer |
| E.J. Holowicki | Sound Effects Editor |
| Shaun Farley | Sound Effects Editor |
| Brad Semenoff | ADR Supervisor |
| Robert Shoup | Foley Supervisor |
| Jeremy Molod | Foley Editor |
| Dennie Thorpe | Foley Artist |
| Jana Vance | Foley Artist |
| Chris Manning | Foley Mixer |
| David Lucarelli | ADR Recordist |
| Connor Nagy | ADR Recordist |
| Natasha Leonnet | Digital Intermediate Colorist |
| Devon Miller | Digital Intermediate Editor |
| Jeff Carson | Music Editor |
| Jim Harrison | Music Editor |
| Andrew Dorfman | Music Editor |
| John Houlihan | Music Supervisor |
| Christian Kaplan | Casting |
| Gary Summers | Additional Sound Re-Recording Mixer |
| Jony Chandra | Head of Story |
