 | Harrison Ford als Indiana Jones |
 | Sean Connery als Henry Jones |
 | Denholm Elliott als Marcus Brody |
 | Alison Doody als Elsa Schneider |
 | John Rhys-Davies als Sallah |
 | Julian Glover als Walter Donovan |
 | River Phoenix als Young Indy |
 | Michael Byrne als Vogel |
 | Kevork Malikyan als Kazim |
 | Robert Eddison als Grail Knight |
 | Richard Young als Fedora |
 | Alexei Sayle als Sultan |
 | Alex Hyde-White als Young Henry |
| Paul Maxwell als Panama Hat |
 | Isla Blair als Mrs. Donovan |
 | Vernon Dobtcheff als Butler |
| J.J. Hardy als Herman |
 | Bradley Gregg als Roscoe |
 | Jeff O'Haco als Half Breed |
| Vince Deadrick Sr. als Rough Rider |
| Marc Miles als Sheriff |
 | Ted Grossman als Deputy Sheriff |
| Tim Hiser als Young Panama Hat |
| Larry Sanders als Scout Master |
| Will Miles als Scout #1 |
| David Murray als Scout #2 |
 | Frederick Jaeger als World War One Ace |
| Jerry Harte als Professor Stanton |
 | Billy J. Mitchell als Dr. Mulbray |
| Martin Gordon als Man at Hitler Rally |
 | Paul Humpoletz als German Officer at Hitler Rally |
| Tom Branch als Hatay Soldier in Temple |
| Graeme Crowther als Zeppelin Crewman |
| Luke Hanson als Principal SS Officer at Castle |
| Chris Jenkinson als Officer at Castle |
| Nicola Scott als Female Officer at Castle |
| Louis Sheldon als Young Officer at Castle |
 | Stefan Kalipha als Hatay Tank Gunner |
 | Peter Pacey als Hatay Tank Driver |
 | Pat Roach als Gestapo |
 | Suzanne Roquette als Film Director |
 | Eugene Lipinski als G-Man |
 | George Malpas als Man on Zeppelin |
 | Julie Eccles als Irene |
| Nina Armstrong als Flower Girl |
| Albert Evansky als Librarian (uncredited) |
 | Ronald Lacey als Gestapo (uncredited) |
 | Michael Sheard als Adolf Hitler (uncredited) |
 | Roy Beck als German Customs Official (uncredited) |
| Paul Markham als Airport Passenger SA Officer (uncredited) |
| Hugh Elton als Zeppelin Passenger (uncredited) |
| Lee Richards als Zeppelin Passenger (uncredited) |
 | Nick Gillard als Tank Crewman Hit by Periscope (uncredited) |
 | Tip Tipping als Tank Crewman (uncredited) |
 | Chris Webb als Castle Brunwald Radio Officer (uncredited) |
 | Paul Heasman als Castle Brunwald Officer (uncredited) |
 | Derek Lyons als German Soldier (uncredited) |
 | Vic Armstrong als German Soldier (uncredited) |
 | Peter Diamond als German Soldier (uncredited) |
| Martin Grace als German Soldier (uncredited) |
 | Dickey Beer als German Agent (uncredited) |
| Wayne Michaels als German Agent (uncredited) |
| Graham Cole als Henchman (uncredited) |
| Steven Spielberg | Director |
| Robert Watts | Producer |
| George Lucas | Executive Producer |
| Frank Marshall | Executive Producer |
| Arthur F. Repola | Producer |
| Philip Kaufman | Characters |
| Jeffrey Boam | Screenplay |
| John Williams | Original Music Composer |
| Douglas Slocombe | Director of Photography |
| Michael Kahn | Editor |
| Maggie Cartier | Casting |
| Mike Fenton | Casting |
| Valorie Massalas | Casting |
| Judy Taylor | Casting |
| Ben Burtt | Sound Designer |
| George Lucas | Characters |
| Nick Gillard | Stunts |
| Tip Tipping | Stunts |
| Stephen Scott | Art Direction |
| Mark White | Driver |
| Vic Armstrong | Stunt Coordinator |
| Wayne Toth | Special Effects |
| Menno Meyjes | Story |
| Joanna Johnston | Costume Design |
| Anthony Powell | Costume Design |
| Zoltan Elek | Makeup Artist |
| Robert L. Stevenson | Hairstylist |
| Russell McEntyre | Transportation Captain |
| Terry Pritchard | Driver |
| Paul Beeson | Additional Photography |
| Michael Gleason | Visual Effects Editor |
| Sandina Bailo-Lape | Sound Effects Editor |
| Melissa Taylor | Production Coordinator |
| David H. Watkins | Special Effects Supervisor |
| Joss Williams | Special Effects Supervisor |
| Jim Dowdall | Stunts |
| Gene Kearney | Grip |
| E. Larry Oatfield | Sound Editor |
| Steve Kelso | Stunts |
| Julián Mateos | Set Decoration |
| Artist W. Robinson | Assistant Director |
| Peter Howitt | Set Decoration |
| Michele Tandy | Production Accountant |
| George Lucas | Story |
| Tony Cridlin | Grip |
| Eddie Powell | Stunts |
| Richard Hymns | Sound Effects Editor |
| Elliot Scott | Production Designer |
| Steven Lambert | Stunt Double |
| Steven Lambert | Stunts |
| Frank Marshall | Second Unit Director |
| Michael D. Moore | Second Unit Director |
| Arthur F. Repola | Associate Producer |
| David Tomblin | First Assistant Director |
| Patricia Carr | Production Supervisor |
| Roy Button | Production Manager |
| Lee Cleary | Second Assistant Director |
| Patrick Kinney | Second Assistant Director |
| Joan Bradshaw | Production Manager |
| Ian Bryce | Production Manager |
| Dennis Maguire | First Assistant Director |
| Artist W. Robinson | Second Assistant Director |
| Freddie Hice | Stunts |
| Elliot Scott | Production Design |
| Tom Stoppard | Dialogue |
| Addison Teague | Sound Effects Editor |
