 | Debi Derryberry als Jimmy Neutron (voice) |
 | Tara Strong als Timmy Turner (voice) |
 | Jeff Garlin als Villain (voice) |
 | Rob Paulsen als Carl / Eustace / Butler / Bucky McBadbat (voice) |
 | Jeffrey Garcia als Sheen Estevez (voice) |
 | Carolyn Lawrence als Cindy Vortex / Mrs. Folfax (voice) |
 | Crystal Scales als Libby Folfax (voice) |
 | Mark DeCarlo als Hugh Neutron (voice) |
 | Megan Cavanagh als Judy Neutron (voice) |
 | Jason Marsden als Chester McBadbat (voice) |
 | Gary LeRoi Gray als A.J. (voice) |
 | Susanne Blakeslee als Wanda / Mom (voice) |
 | Daran Norris als Cosmo / Dad (voice) |
 | Carlos Alazraqui als Mr. Crocker (voice) |
 | Billy West als Blix / British Official / Sam / Corky Shimazu (voice) |
 | Jay Leno als Nega-Chin (voice) |
 | Grey DeLisle als Vicky (voice) |
| Keith Alcorn | Director |
| Mike Gasaway | Director |
| Butch Hartman | Director |
| Rico Hill | Original Concept |
| Steve Marmel | Writer |
| Jed Spingarn | Writer |
| John A. Davis | Creator |
| Butch Hartman | Creator |
| Keith Alcorn | Co-Executive Producer |
| John A. Davis | Executive Producer |
| Butch Hartman | Executive Producer |
| Paul Marshal | Producer |
| Steve Oedekerk | Executive Producer |
| Jed Spingarn | Executive Producer |
| Jed Spingarn | Co-Executive Producer |
| Charlie Brissette | Music |
| Guy Moon | Music |
| Joe E. Elwood | Editor |
| Randy Saba | Production Manager |
| Kim Benzine-Rowell | Production Manager |
| Ernie Gilbert | Art Direction |
| Deanna Molinaro | Supervising Animator |
| Ernest Chan | CG Supervisor |
| Robert Poole II | Sound Designer |
| Robert Poole II | Sound Effects Editor |
| Paul Menichini | Sound Designer |
| Paul Menichini | Sound Effects Editor |
| Ray Leonard | Sound Re-Recording Mixer |
| Michael Beiriger | Sound Re-Recording Mixer |