 | Dwayne Johnson als Dr. Smolder Bravestone |
 | Kevin Hart als Franklin 'Mouse' Finbar |
 | Jack Black als Professor Sheldon 'Shelly' Oberon |
 | Karen Gillan als Ruby Roundhouse |
 | Awkwafina als Ming |
 | Nick Jonas als Jefferson 'Seaplane' McDonough |
 | Alex Wolff als Spencer Gilpin |
 | Morgan Turner als Martha Kaply |
 | Madison Iseman als Bethany |
 | Ser'Darius Blain als Anthony 'Fridge' Johnson |
 | Danny DeVito als Eddie |
 | Danny Glover als Milo |
 | Rhys Darby als Nigel Billingsley |
 | Colin Hanks als Alex |
 | Rory McCann als Jurgen the Brutal |
 | Marin Hinkle als Spencer's Mom |
 | Vince Pisani als Pharmacy Manager |
 | Dorothy Steel als Village Elder |
 | Jennifer Patino als Bravestone's Mother |
 | Madison Johnson als Little Bethany Vreeke |
 | Dania Ramírez als Lady in Red |
 | Derek Russo als Key Master |
 | Nick Gomez als Oasis Drunk |
 | Massi Furlan als Switchblade |
 | Javier Villamil als Switchblade's Sidekick |
 | Anthony Neves als Jurgen's Patrolman |
 | Morgan Brown als Fortress Guard |
 | Deobia Oparei als Elevator Guard |
 | Leslie Simms als Cake Lady |
 | John Ross Bowie als Cavendish |
 | Lucy DeVito als Maiden |
 | Bebe Neuwirth als Nora |
 | Lamorne Morris als Heater Repair Guy |
 | Darin Ferraro als The Gun Seller (uncredited) |
 | Sal Longobardo als Tony (uncredited) |
 | Michael Beasley als Coach Davis (uncredited) |
 | Charles Green als Bartender (uncredited) |
| James William Ballard als Bad Guy in Fortress (uncredited) |
 | Kodai Yamaguchi als Jumanjian Villager (uncredited) |
 | Ashley Scott als Ashley (uncredited) |
 | Melissa Kennemore als Marauder 1 / Jergens Inner Circle (uncredited) |
 | Vanessa Cater als Red Headed Marauder (uncredited) |
| John David Bulla als Groovy Face Tattoo Biker (uncredited) |
| Ryan Cheeseman als Marauder (uncredited) |
| Cruz Abelita als Messenger Boy (uncredited) |
 | Sheril Rodgers als New York City Pedestrain (uncredited) |
 | Bruno Rose als NY Dorm Guy (uncredited) |
| Matt Tolmach | Producer |
| Jeff Pinkner | Writer |
| Jake Kasdan | Director |
| Hiram Garcia | Producer |
| Dany Garcia | Producer |
| Scott Rosenberg | Writer |
| Dwayne Johnson | Producer |
| Bill Brzeski | Production Design |
| Ted Field | Executive Producer |
| Mike Weber | Executive Producer |
| Kevin Kersting | Grip |
| Andrew Max Cahn | Supervising Art Director |
| Mark Breakspear | Visual Effects Supervisor |
| Steve Edwards | Editor |
| David B. Householter | Executive Producer |
| Jeff Pinkner | Executive Producer |
| Nicole Abellara Hallman | Casting Director |
| Michael Gowen | Art Direction |
| Drew Monahan | Art Direction |
| Danielle Berman | Set Decoration |
| Jake Kasdan | Producer |
| Gyula Pados | Director of Photography |
| Jeanne McCarthy | Casting Director |
| Henry Jackman | Original Music Composer |
| Brian Stultz | Art Direction |
| Stella Vaccaro | Art Direction |
| Jake Kasdan | Writer |
| Melvin Mar | Executive Producer |
| Scott Rosenberg | Executive Producer |
| Chris Van Allsburg | Executive Producer |
| William Teitler | Executive Producer |
| Louise Mingenbach | Costume Design |
| Nathan Kimball | Second Second Assistant Director |
| Chris Van Allsburg | Book |
| Joann Connolly | Second Assistant Director |
| Kristina M. Peterson | Second Second Assistant Director |
| Wainani Young-Tomich | First Assistant Director |
| Wade Eastwood | Second Unit Director |
| Matt Rebenkoff | First Assistant Director |
| David Conk | Stunts |
| Danny Le Boyer | Stunts |
| John Evanko | Stunts |
| Chad Bowman | Stunts |
| Scott Armstrong | Stunt Coordinator |
| Ruben Maldonado | Stunts |
| Theo Kypri | Stunts |
| Shawnna Thibodeau | Stunts |
| Tanoai Reed | Stunt Double |
| Roel Failma | Stunts |
| Dave Van Zeyl | Stunts |
| Alyma Dorsey | Stunts |
| Chris Balualua | Stunts |
| Branden Arnold | Stunts |
| Shauna Galligan | Stunts |
| Joshua Romeo | Stunts |
| Allan Henry | Stunts |
| Lucy Cork | Stunt Double |
| Jimmy Waitman | Stunt Double |
| Sara Price | Stunts |
| Chris Naylor | Stunts |
| Rob Mars | Stunts |
| Isaac Hamon | Stunt Coordinator |
| J.J. Dashnaw | Stunts |
| Jahnel Curfman | Stunt Double |
| Marc Canonizado | Stunts |
| Craig Henningsen | Stunts |
| Adrian Hein | Stunts |
| Troy Butler | Stunts |
| Wolfgang Stegemann | Fight Choreographer |
| Nate Hitpas | Stunts |
| Wade Eastwood | Stunt Coordinator |
| Lee Chesley | Stunt Double |
| Vanessa Cater | Stunts |
| Rhys Millen | Stunts |
| Michael Hansen | Stunts |
| Justin Eaton | Stunts |
| Matt Berberi | Stunts |
| Myles Humphus | Stunt Double |
| Stephane Fiossanangaye | Stunts |
| Josh Diogo | Stunts |
| Tom McComas | Stunts |
| Jess King | Stunts |
| Greg Harris | Stunts |
| Simeon Freeman | Stunts |
| John Cihangir | Stunts |
| Randy James Beckman | Stunts |
| Samuel J. Paul | Stunt Double |
| Michael Jamorski | Stunts |
| Tad Griffith | Stunts |
| Thomas Joseph Culler | Stunts |
| Joe Ross | Stunts |
| Brice Liesveld | Visual Effects Producer |
| Sky Salem Robinson | Associate Producer |
| Kay Hoddy | Rotoscoping Artist |
| Bahget Abdalmalek | VFX Artist |
| Charles Abou Aad | CG Supervisor |
| Breanna Adams | VFX Production Coordinator |
| Ritesh Aggarwal | Stereoscopic Supervisor |
| Lydia Aguilar | Compositor |
| Wakeel Ahmad | Rotoscoping Artist |
| Ryan Allen | Compositor |
| Shudhdodhan Milind Ambhore | VFX Artist |
| Ndosi Anyabwile | Compositor |
| Jahan Arsi | VFX Artist |
| Jonathan Asselin | Animation |
| Myles Asseter | Modelling Supervisor |
| Steve Barnes | Compositor |
| Tricia Barrett | Compositor |
| Cory Bedwell | Matte Painter |
| Steven Benjamin | Compositor |
| Daniel Berkowitz | Compositor |
| Alex Berson | Compositing Artist |
| Riley Flanagan | Key Set Production Assistant |
| David Manpearl | Co-Producer |
| Denise Acosta | Art Department Assistant |
