 | Patrick Warburton als Kronk (voice) |
 | Tracey Ullman als Ms. Birdwell (voice) |
 | Eartha Kitt als Yzma (voice) |
 | David Spade als Kuzco (voice) |
 | John Goodman als Pacha (voice) |
 | Wendie Malick als Chicha (voice) |
 | John Mahoney als Papi (voice) |
 | John Fiedler als Rudy (voice) |
 | Jeff Bennett als Additional Voices (voice) |
 | Bob Bergen als Bucky (voice) |
 | Brian Cummings als Additional Voices (voice) |
 | Patti Deutsch als Waitress (voice) |
 | Anthony Ghannam als Huayna (voice) |
 | Michaela Jill Murphy als Chaca (voice) |
 | Eli Russell Linnetz als Tipo (voice) |
 | Mark Lotito als Additional Voices (voice) |
 | Tress MacNeille als Additional Voices (voice) |
 | Travis Oates als Additional Voices (voice) |
 | Grace Rolek als Additional Voices (voice) |
| Leily Sanchez als Additional Voices (voice) |
 | Ross Simanteris als Additional Voices (voice) |
 | Kath Soucie als Additional Voices (voice) |
 | April Winchell als Hildy / Marge / Tina (voice) |
 | Gatlin Kate James als Additional Voices (voice) |
| John A. Smith | Producer |
| Colin Stimpson | Production Design |
| Elliot M. Bour | Director |
| Peter Denomme | Executive Producer |
| Mark Watters | Original Music Composer |
| Jeanine Tesori | Original Music Composer |
| Philip Malamuth | Editor |
| Tony Leondis | Story |
| Tom Rogers | Screenplay |
| Tom Rogers | Story |
| Saul Blinkoff | Director |
| Michael LaBash | Story |
| Cal Brunker | Animation |
| Dennis Venizelos | Background Designer |
| Micki Zurcher | Background Designer |
| Blair Kitchen | Animation |
| Kezia Ma | Animation |
| Keith Rogers | Sound Re-Recording Mixer |
| Terry O'Bright | Sound Re-Recording Mixer |
| Scott T. Petersen | Animation Supervisor |
| Ronald Eng | Supervising Sound Editor |
| Doug Little | Visual Effects Supervisor |
| Mary Locatell | Art Direction |
| David Reynolds | Characters |
| Joel Halvorson | Post-Production Manager |
| William C. Turner | Production Manager |
| Pierre Chiasson | Production Manager |
| Helen O'Flynn | Continuity |
| Mark A. Bollinger | Post Production Supervisor |
| Lynn Singer | Continuity |
| Christopher Kracker | Production Manager |
| Chris Williams | Characters |
| Christopher Chase | Development Producer |
| Nick Yates | Continuity |
| Robin Steele | Second Unit Director |
| Jamie Thomason | Casting |
| Kate Crandall | Production Supervisor |
| Mark Dindal | Characters |
| Traci Balthazor | Production Manager |
| Jonathon Tinsay | Production Manager |
| José Zelaya | Character Designer |
| Cooper Cowgill | ADR & Dubbing |
| Jeff Draheim | Supervising Editor |
| Arthur D. Noda | Associate Editor |
| David Block | Animation Supervisor |
| Heather McClenahan | Technical Supervisor |
| Dana Landsberg | Character Designer |
| Michael Cedeno | Character Designer |
| Joe Moshier | Character Designer |
| Russ Mooney | Animation Director |
| Dante Clemente | Animation Director |
| Levy Vergara | Layout Supervisor |
| Akiblas Flores | Effects Supervisor |
| Fernan Jose Lagran | CGI Supervisor |
| Roger Chiasson | Animation Supervisor |
| Darren Donovan | Effects Supervisor |
| Carla Arcuri | Production Coordinator |
| Jessica Dalton | Production Coordinator |
| Sean Reed | Production Coordinator |
| Michael Siemen | Production Coordinator |
| Geri Bryan | Post Production Coordinator |
| Carol Lewis | Supervising Dialogue Editor |
| Doug Jackson | Sound Editor |
| Steve Tushar | Sound Editor |
| Robert Troy | Dialogue Editor |
| Steven Gizicki | Music Supervisor |
| Dominick Certo | Music Editor |
| John Fiedler | In Memory Of |
| Steven Clay Hunter | Animation |
