 | Seth Rogen als Ben Stone |
 | Katherine Heigl als Alison Scott |
 | Paul Rudd als Pete |
 | Leslie Mann als Debbie |
 | Jason Segel als Jason |
 | Jay Baruchel als Jay |
 | Jonah Hill als Jonah |
 | Martin Starr als Martin |
 | Charlyne Yi als Jodi |
 | Iris Apatow als Charlotte |
 | Maude Apatow als Sadie |
 | Joanna Kerns als Alison's Mom |
 | Harold Ramis als Ben's Dad |
 | Alan Tudyk als Jack |
 | Kristen Wiig als Jill |
 | Bill Hader als Brent |
 | Ken Jeong als Dr. Kuni |
 | Craig Robinson als Club Doorman |
 | Tim Bagley als Dr. Pellagrino |
 | Loudon Wainwright III als Dr. Howard |
 | Stephanie Mnookin als Dr. Howard's Nurse |
 | Adam Scott als Samuel |
| J.P. Manoux als Dr. Angelo |
 | Mo Collins als Female Doctor |
 | B.J. Novak als Young Doctor |
 | Tami Sagher als Wardrobe Lady |
 | Brianna Brown als Alison's Friend |
 | Catherine Reitman als Alison's Friend |
 | Nick Thune als Alison's Friend |
 | Paul Feig als Fantasy Baseball Guy |
 | Ben Meyerson als Fantasy Baseball Guy |
 | Wayne Federman als Fantasy Baseball Guy |
 | Melinda Bennett als Dr. Pellagrino's Nurse |
 | Matthew McKane als Club Bartender |
 | Steven Brill als Ben's Boss |
 | Ana Mercedes als Maria |
| Nadine Griffith als Maternity Nurse at Desk |
| Diane Schaller als Delivery Nurse |
| Emersen Riley als Jonah's Girlfriend |
 | Stormy Daniels als Lap Dancer |
 | Nautica Thorn als Lap Dancer |
| Mary Brill als Real Estate Agent |
| Lolita Mastrolia als Daughter in Waiting Room |
| Joseph T. Mastrolia als Father in Waiting Room |
| Tracy Hartley als Lamaze Instructor |
| Jeffrey L. Wilson als Record Store Customer |
 | Theodore Borders als (voice) |
 | Ranjani Brow als (voice) |
 | Rachel Crane als (voice) |
| Caitlin Cutt als (voice) |
 | Wendy Hoffmann als (voice) |
 | Scott Menville als (voice) |
 | Shani Pride als (voice) |
| Christina Rodgers als (voice) |
 | Justin Shenkarow als (voice) |
 | Shane Sweet als (voice) |
 | John Hans Tester als (voice) |
| Tyler Zaentz als (voice) |
 | Jessica Alba als Herself (uncredited) |
 | Steve Carell als Himself (uncredited) |
 | Andy Dick als Himself (uncredited) |
 | James Franco als Himself (uncredited) |
 | Eva Mendes als Herself (uncredited) |
 | Ryan Seacrest als Himself (uncredited) |
 | Dax Shepard als Himself (uncredited) |
 | Michelle Woods als Waitress (uncredited) |
| Judd Apatow | Director |
| Judd Apatow | Screenplay |
| Judd Apatow | Producer |
| Shauna Robertson | Producer |
| Clayton Townsend | Producer |
| Joe Henry | Original Music Composer |
| Eric Alan Edwards | Director of Photography |
| Craig Alpert | Editor |
| Brent White | Editor |
| Allison Jones | Casting |
| Jefferson Sage | Production Design |
| Lauren E. Polizzi | Art Direction |
| Chris L. Spellman | Set Decoration |
| Debra McGuire | Costume Design |
| Evan Goldberg | Executive Producer |
| Seth Rogen | Executive Producer |
| Loudon Wainwright III | Original Music Composer |
| Jesse Heiman | Stand In |
| Clayton Townsend | Unit Production Manager |
| Matt Rebenkoff | First Assistant Director |
| Courtenay Miles | Second Assistant Director |
| Malosi Leonard | Stunt Coordinator |
| Matt Leonard | Stunts |
| Melissa Bretherton | Additional Editor |
| Gary R. Wordham | Production Supervisor |
| Elizabeth Lapp | Set Designer |
| Alicia Maccarone | Set Designer |
| Masako Masuda | Set Designer |
| Mark Weissenfluh | Leadman |
| Ari Jacobs | Art Department Coordinator |
| Peter Rosenfeld | Camera Operator |
| Peter Rosenfeld | Steadicam Operator |
| Nils Benson | Camera Operator |
| Scott Rathner | First Assistant Camera |
| Paul Horn | First Assistant Camera |
| Peter Geraghty | Second Assistant Camera |
| Paul Tilden | Second Assistant Camera |
| Greg Kurtz | Camera Loader |
| David MacMillan | Sound Mixer |
| Harrison D. Marsh | Boom Operator |
| Jack M. Nietzsche Jr. | Boom Operator |
| Kevin E. Patterson | Utility Sound |
| Barrett J. Leigh | Production Coordinator |
| Sean Mannion | Property Master |
| Michael Glynn | Assistant Property Master |
| Jack Blanchard | Set Dresser |
| Mark Green | Set Dresser |
| Scott G. Jones | Set Dresser |
| Adam Kirby | Set Dresser |
| Anthony Klaiman | Set Dresser |
| Nashon Petrushkin | Set Dresser |
| Joseph T. Mastrolia | Costume Supervisor |
| Katrina Mastrolia | Costume Supervisor |
| Catherine Hahn | Costumer |
| Thomas Real | Key Hair Stylist |
| Nancy Tong | Hairstylist |
| Ann Pala | Key Makeup Artist |
| Kathleen Freeman | Makeup Artist |
| Don Bixby | Chief Lighting Technician |
| Marc Marino | Best Boy Electric |
| Craig A. Brink | Rigging Gaffer |
| Doug Cowden | Key Grip |
| Walter Royle | Best Boy Grip |
| Gary A. Williams | Dolly Grip |
| Matt Sweeney | Special Effects Supervisor |
| George H. Anderson | Supervising Sound Editor |
| Rebecca Asher | Script Supervisor |
| Scott Millan | Sound Re-Recording Mixer |
| David Parker | Sound Re-Recording Mixer |
| Lisa Rodgers | Post Production Supervisor |
| Ray Neapolitan | First Assistant Editor |
| Tammy Fearing | Supervising ADR Editor |
| Cindy Marty | Sound Effects Editor |
| Joe Schiff | Dialogue Editor |
| Cherie Tamai | First Assistant Sound Editor |
| Mike Revell | Production Accountant |
| Boyd Wilson | Location Manager |
| Anthony Lattanzio | Construction Coordinator |
| Jay M. Huntoon | Video Assist Operator |
| Suzanne Hanover | Still Photographer |
| Deborah Wuliger | Unit Publicist |
| Wendy Hoffmann | ADR Voice Casting |
| Greg Steele | ADR Mixer |
| Greg Zimmerman | ADR Recordist |
| Goro Koyama | Foley Artist |
| Caoimhe Doyle | Foley Artist |
| Andy Malcolm | Foley Artist |
| Jonathan Karp | Music Editor |
| Gary Burritt | Negative Cutter |
| Thom 'Coach' Ehle | Dolby Consultant |
| Jonathan Karp | Music Supervisor |
| Bert Smith | Assistant Property Master |
| Jon Nicholson | On Set Dresser |
| Kristen Gassner | Set Decoration Buyer |
| Jennifer Iizuka | Key Set Costumer |
| Michael A. Russell | Key Set Costumer |
| Winifred Clements | Other |
| Matthew W. Mungle | Prosthetic Designer |
| Matthew W. Mungle | Prosthetic Makeup Artist |
| Clinton Wayne | Prosthetic Makeup Artist |
| Ruth Haney | Prosthetic Makeup Artist |
| Pauletta O. Lewis | Hairstylist |
| Charlotte Parker | Hairstylist |
| Corina C. Duran-Rabichuk | Makeup Artist |
| Alexis Walker | Makeup Artist |
| Ann Pala | Makeup Artist |
| Jason Brunelle | Lighting Technician |
| Jimmy Ellis | Lighting Technician |
| Gordon Tadd Eto | Lighting Technician |
| Earl Gayer | Lighting Technician |
| William Streit | Lighting Technician |
| Chris Weigand | Lighting Technician |
| David Diamond | Best Boy Electric |
| Brandon Ainsworth | Electrician |
| Randy Babchuck | Electrician |
| Kevin Cadwallader | Electrician |
| Gustavo Graciano | Electrician |
| Glen Magers | Electrician |
| Marc Salter | Electrician |
| Marc Wostak | Electrician |
| Anthony Thomas | Dolly Grip |
| Bruce Byall | Grip |
| Shannon Deats | Grip |
| Sammy Escobar | Grip |
| Grant Goza | Grip |
| Eric Leach | Grip |
| Matt Jackson | Grip |
| Tomy Sommo | Grip |
| Teague Uva | Grip |
| Jeffrey L. Wilson | Grip |
| Bill-Brady Majors | Key Rigging Grip |
| Caleb R. Nelson | Best Boy Grip |
| Craig Bilodeau | Rigging Grip |
| Pete Johnson | Rigging Grip |
| Cory Peauler | Rigging Grip |
| Edward Pickrell | Rigging Grip |
| Lance Robinson | Rigging Grip |
| Bill H. Schwocho | Rigging Grip |
| Hannes Steixner | Rigging Grip |
| Steve Luport | Special Effects Technician |
| Lucinda Strub | Special Effects Technician |
| Scott M. Davids | Associate Editor |
| Laura Behary | Assistant Editor |
| Colin Patton | Assistant Editor |
| Jim Carretta | Editorial Production Assistant |
| Bill Burns | ADR Editor |
| Andrew Epstein | Producer's Assistant |
| Greg Cohen | Producer's Assistant |
| Lisa Goldberg | Producer's Assistant |
| Eileen M. Dennis | First Assistant Accountant |
| Naomi Catalano | Second Assistant Accountant |
| Jennifer K. Jacobs | Second Assistant Accountant |
| Karen M. Fuchs | Payroll Accountant |
| Luika Imaoka | Accountant |
| James Maull | Post Production Accountant |
| Brad Bell | Assistant Location Manager |
| Jacob Charney | Assistant Location Manager |
| Naomi Motohashi | Assistant Location Manager |
| Jim Small | Assistant Location Manager |
| David B. Nowell | Aerial Director of Photography |
| Peter McKernan | Pilot |
| Lance Strumpf | Health and Safety |
| Dorian Frankel | Casting Assistant |
| Deedra Ricketts | Extras Casting |
| Carla Lewis | Extras Casting |
| Tina Kerr | Extras Casting |
| Selena Carrillo | Assistant Production Coordinator |
| Brook Worley | Assistant Production Coordinator |
| Kate Galbraith | Production Secretary |
| Paul Schneider | Second Second Assistant Director |
| Kathryn Tucker | Set Production Assistant |
| Blake Nabavi | Set Production Assistant |
| Jadi McCurdy | Set Production Assistant |
| Marike Jainchill | Set Production Assistant |
| Matthew Bass | Production Assistant |
| Michelle Beress | Production Assistant |
| Chase Fein | Production Assistant |
| Stuart Bam | Production Assistant |
| Robbie Woolrich | Production Assistant |
| Hunter Woo | Art Department Assistant |
| Dennis Geraghty | Camera Production Assistant |
| Michelle Finkelstein | Costume Assistant |
| Samantha Davis | Costume Assistant |
| Justin Harrold | Location Production Assistant |
| Jacob M. Torres | Location Production Assistant |
| Aaron Critchlow | Assistant Director Trainee |
| Christopher W. Meyer | Construction Foreman |
| Anthony Godfrey | Propmaker |
| Terry Miller | Construction Foreman |
| Eugenio Quinteru | Construction Foreman |
| David Goldstein | Paint Coordinator |
| Bill 'Kauhane' Hoyt | Standby Painter |
| Armando Abarca | Construction Foreman |
| Tony Castagnola | Greensman |
| Mike Shannon | Transportation Coordinator |
| Oliver Eisenger | Transportation Captain |
| Jayson Chang | Transportation Co-Captain |
| Julie Sanders | Transportation Co-Captain |
| Steve Irwin | Playback Coordinator |
| Eric Roberts | Video Assist Operator |
| Tom Schurke | Video Assist Operator |
| Casey L. Kamps | Dailies Operator |
| Joyce Mannon | Other |
| Melody Murray | Other |
| Chance Tassone | Craft Service |
| Joseph Milito | Craft Service |
| Rhona Gordon | Studio Teacher |
| Didi Vitale | Set Medic |
| Ericka Bryce | Set Medic |
| Susie Schelling | Technical Advisor |
| Drew Webster | ADR & Dubbing |
| Don White | Foley Recordist |
| Ron Mellegers | Foley Recordist |
| Anna Malkin | Foley Recordist |
| Jenna Dalla Riva | Foley Recordist |
| Kathy Nelson | Executive Music Producer |
| Lyle Workman | Additional Music |
| David Piltch | Musician |
| Jay Bellerose | Musician |
| Richard Thompson | Musician |
| Greg Leisz | Musician |
| Patrick Warren | Musician |
| Ryan Freeland | Scoring Mixer |
| Jeff Smithwick | Color Timer |
| Jimmy Fusil | Digital Intermediate Producer |
| Josh Bleibtreu | Second Unit Director of Photography |
| Dawn Massaro | Second Unit First Assistant Director |
| Heather Grierson | Second Assistant Director |
| Don Steinberg | First Assistant Camera |
| Steven Cueva | Second Assistant Camera |
| Jody Hart | Stunt Driver |
