 | Andy Dick als The Slasher (voice) |
 | Mischa Barton als The Actress |
 | Eric Roberts als The Mayor |
 | Abigail Wright als The Reporter |
 | Tori Black als The Teen Mom |
 | Carlee Baker als Scream Queen |
 | Barbara Nedeljakova als Scream Queen |
 | Ashlynn Yennie als Scream Queen |
 | Dave Bautista als The Drug Dealer #1 |
 | Danny Trejo als The Drug Dealer #2 |
 | Marisa Lauren als The Stripper |
 | Brooke Hogan als The Reality Star |
 | Drake Bell als The Pop Star |
 | Frank Collison als Killers Anonymous Leader |
| Tim Burke als The Producer |
 | Allison Kyler als Scream Queen |
| William Nicol als CBuzz Host |
 | Jane Noble als Mother |
| Andrew de Burgh als Waiter |
 | Franklin Ruehl als Dinner Guest |
 | Amanda Fields als Masked Slasher |
 | Jamie Bernadette als The Detective (deleted scene) |
 | Bill Clinton als Self (archive footage) |
| Abigail Wright | Producer |
| Daniel Sollinger | Producer |
| Shree Patel | Producer |
| Martin Owen | Director |
| Martin Owen | Writer |
| Drew Suppa | First Assistant Camera |
| Willy Allen | Foley |
| Emanuele Giraldo | Editor |
| Ari Levinson | Visual Effects Supervisor |
| Brittany Ann Cormack | Costume Design |
| Skoti Collins | Casting Associate |
| Cassandra Surina | Production Design |
| Leslie Borchard | Key Hair Stylist |
| Rusty Dunn | Sound Designer |
| Elizabeth Linell | Script Supervisor |
| Ronnie Gotch | Gaffer |
| Jonathan Willis | Producer |
| Lee Komet | Makeup Department Head |
| Jonathon Henry | First Assistant Camera |
| Tiffany Roysden | Hairstylist |
| Neely Gurman | Casting |
| Robert Chen | Sound Re-Recording Mixer |
| Barnabas Prontnicki | Property Master |
| Jeffrey D. Wright | Producer |
| Chase Bowman | Director of Photography |
| Barbara Friedman | Script Supervisor |
| Keith Croket | Editor |
| Matilda G. Paulin | Art Direction |
| Patrick P. Smith | Helicopter Camera |
| Justin Tyme | Makeup Artist |
| Sabrina Cruz Castro | Makeup Artist |
| Alex Noble | Key Makeup Artist |
| Jill Fogel | Makeup Artist |
| Jarod Collins | Set Dresser |
| Michael Nelson | Assistant Camera |
| Mitch Swan | Publicist |
| Sulekh Suman | Digital Imaging Technician |
| Joe Sloan | Sound Mixer |
| Vito Huizar | Assistant Camera |
| Vicky Constantinou | Electrician |
| Rupert Hollier | Music Supervisor |
| David Desio | Assistant Camera |
| Kirk Michael Fellows | First Assistant Director |
| Patrick P. Smith | Aerial Director of Photography |
| Sebastian Chung | Second Assistant Camera |
| Joseph William Maloney | Production Coordinator |
| Jake Koenig | Best Boy Electric |
| Joseph Ascioti | Best Boy Grip |
| Andrew Rodger | Second Unit Director of Photography |
| Chance Pemberton | ADR Engineer |
| David Thomas Graves | Gaffer |
| Jason M. Norman | Grip |
| Michael Warren | Production Manager |
| Joseph Suarez | First Assistant Director |
| Mac Quayle | Original Music Composer |
