 | Antonio Banderas als Dr. Robert Ledgard |
 | Elena Anaya als Vera Cruz |
 | Marisa Paredes als Marilia |
 | Jan Cornet als Vicente |
 | Roberto Álamo als Zeca |
 | Eduard Fernández als Fulgencio |
 | José Luis Gómez als Presidente del Instituto de Biotecnología |
 | Blanca Suárez als Norma Ledgard |
 | Susi Sánchez als Madre de Vicente |
 | Bárbara Lennie als Cristina |
 | Fernando Cayo als Médico |
 | Chema Ruiz als Policía |
 | Buika als Cantante |
 | Ana Mena als Norma Joven |
| Teresa Manresa als Casilda Efraiz |
 | Fernando Iglesias |
 | Agustín Almodóvar als Agustín |
| Miguel Almodóvar als Hijo de Agustín |
| Marta R. Mahou als Profesora de Yoga en TV |
 | Gabriel Barbosa als Zeca (Child) (uncredited) |
 | Esther García als Presentadora (uncredited) |
| Yolanda Brown als Conference participant |
| Pedro Almodóvar | Director |
| José Salcedo | Editor |
| Pedro Almodóvar | Screenplay |
| Esther García | Producer |
| Alberto Iglesias | Original Music Composer |
| Thierry Jonquet | Novel |
| Antxón Gómez | Production Design |
| Agustín Almodóvar | Additional Writing |
| Agustín Almodóvar | Producer |
| Luis San Narciso | Casting |
| José Luis Alcaine | Director of Photography |
| Montse Ribé | Makeup Effects Designer |
| Bárbara Peiró | Associate Producer |
| Toni Novella | Production Manager |
| Iván Marín | Sound Recordist |
| Pelayo Gutiérrez | Sound Editor |
| Marc Orts | Sound Re-Recording Mixer |
| Karmele Soler | Makeup Artist |
| Manolo Carretero | Hairstylist |
| Paco Delgado | Costume Design |
| Yuyi Beringola | Script Supervisor |
| Sergio Díaz | Unit Production Manager |
| Joaquín Manchado | Camera Operator |
| José Haro | Still Photographer |
| Lucía Faraig | Still Photographer |
| Carlos Bodelón | Art Direction |
| Vicent Díaz | Set Decoration |
| Alejandra Loiseau | Set Designer |
| Juan Dibarboure | Boom Operator |
| Fernando Beltrán | Gaffer |
| David Martí | Special Effects Makeup Artist |
| Montse Ribé | Special Effects Makeup Artist |
| Juan Gatti | Graphic Designer |
| César Molina | Dialogue Editor |
| Álex F. Capilla | Foley Artist |
| Patrick Ghislain | Foley Recordist |
| Adela Donamaría | Production Secretary |
| Oscar Aramburu | Hair Assistant |
| María Barreiro | Hair Assistant |
| Fanny Bello | Assistant Makeup Artist |
| Daniel Coltor | Makeup Artist |
| Cristina Couto | Assistant Makeup Artist |
| Raquel Fidalgo | Assistant Makeup Artist |
| María Illobre | Assistant Makeup Artist |
| José Martínez | Hair Assistant |
| Fani Mosqueira | Hair Assistant |
| Raquel Munuera | Prosthetics |
| Esther Quintas | Assistant Makeup Artist |
| Carlos Rivadulla | Hair Assistant |
| Pablo S. Santomil | Hair Assistant |
| Susana Veira | Assistant Makeup Artist |
| Patricia Vilela | Hair Assistant |
| Tamar Aviv | Special Effects Makeup Artist |
| Federico Rozadillas | Assistant Production Manager |
| Manuel Calvo | First Assistant Director |
| Juan Carlevaris | Assistant Director Trainee |
| Laura Díez | Assistant Director Trainee |
| David Esquivel | Third Assistant Director |
| Patricia González | Second Assistant Director |
| Francisco Lareu | Second Assistant Director |
| Eva Sánchez | Second Assistant Director |
| Ana Valencia | Third Assistant Director |
| Gonzalo Ansó | Props |
| Jesús Calzada | Assistant Decorator |
| Carlota Casado | Assistant Decorator |
| Gabriel del Boca | Graphic Designer |
| Alexandra Fernández | Assistant Decorator |
| Mikel Izaguirre | Standby Property Master |
| Antía León Castro | Set Decoration Buyer |
| Juanan Padilla | Property Master |
| Antón Pena | Props |
| Ramón Rubira | Props |
| Pablo Seoane | Standby Property Master |
| Juan Sánchez | Graphic Designer |
| Juan Ignacio Viñuales | Props |
| Sandra Wahlbeck | Painter |
| Sandra Wahlbeck | Special Props |
| Tania Whalbeck | Painter |
| Tania Whalbeck | Special Props |
| Pablo Buratti | Storyboard Artist |
| José Luis Moya | Construction Coordinator |
| Ramón Moya | Construction Manager |
| Martín Sánchez Fernández | Lead Painter |
| Eduardo Castro | Assistant Sound Editor |
| Diego Díaz | Sound Assistant |
| Mario González | Sound Re-Recording Assistant |
| Rafa Paniagua | Assistant Sound Editor |
| Rafa Paniagua | Sound Effects Editor |
| Josep Prieto | Sound Recordist |
| Eduardo Díaz | Visual Effects Supervisor |
| Helen Martí Donoghue | Visual Effects Producer |
| Sonsoles Aranguren | Digital Compositor |
| Ramón Ramos | Digital Compositor |
| Bahar Cetin | Digital Compositor |
| Yolanda Rubio-Soto | Digital Compositor |
| Pilar Cienfuegos | Digital Compositor |
| Ezequiel Larrú | Digital Compositor |
| Thorsten Rienth | Digital Compositor |
| Guillermo Martínez Benavente | Digital Compositor |
| Paula Rubio | Digital Compositor |
| Chema Alba | Color Timer |
| César Abades | Special Effects Technician |
| Reyes Abades | Special Effects Supervisor |
| Óscar Abades | Special Effects Technician |
| Pablo Perona | Special Effects Makeup Artist |
| Daniel Reboul | Special Effects Technician |
| Joaquín Vergara | Special Effects Technician |
| José Luis Barreiro Gómez | 3D Artist |
| Segundo Casero | 3D Artist |
| Juan Luis Gorjon | 3D Artist |
| Alberto Luceño | 3D Artist |
| Pablo Amores | Stunts |
| Camino Capellín | Stunts |
| Javier Casado Sudupe | Music Producer |
| Andrew Crowley | Musician |
| Fernando Favier | Musician |
| Joulien Ferrer | Musician |
| Iván González Lewis | Musician |
| Vicente Huerta | Musician |
| Inoidel | Musician |
| Peter Lale | Musician |
| Anthony Pleeth | Musician |
| Carlitos Sarduy | Musician |
| Mary Scully | Musician |
| Covadonga R. Gamboa | Production Coordinator |
