 | Will Ferrell als Dr. Rick Marshall |
 | Anna Friel als Holly |
 | Danny McBride als Will Stanton |
 | Jorma Taccone als Chaka |
 | John Boylan als Enik |
 | Matt Lauer als Matt Lauer |
 | Bobb'e J. Thompson als Tar Pits Kid |
 | Sierra McCormick als Tar Pits Kid |
 | Shannon Lemke als Tar Pits Kid |
 | Steven Wash Jr. als Tar Pits Kid |
 | Brian Huskey als Teacher |
| Kevin Buitrago als Teenager |
 | Noah Crawford als Teenager |
 | Jon Kent Ethridge als Teenager |
| Logan Manus als Teenager |
 | Ben Best als Ernie |
| Scott Dorel als Elder Pakuni |
| Sean Michael Guess als Elder Pakuni |
| Dennis McNicholas als Ice Cream Man |
 | Chris Henchy als Stage Manager |
 | Kurt Carley als Sleestak |
| Travis Samuel Clark als Sleestak |
| Daniel George als Sleestak |
 | Todd Christian Hunter als Sleestak |
 | Marti Matulis als Sleestak |
 | Tim Soergel als Sleestak |
 | Douglas Tait als Sleestak |
| Patrick Wedge als Sleestak |
 | Ana Alexander als Pakuni Woman |
| Moran Atlas als Pakuni Woman |
| Jesse Golden als Pakuni Woman |
 | Eve Mauro als Pakuni Woman |
 | Pollyanna McIntosh als Pakuni Woman |
| Ania Spiering als Pakuni Woman |
 | Paul Adelstein als Astronaut (voice) |
| Adam Behr als Library Skull (voice) |
 | Daamen J. Krall als Library Skull (voice) |
 | Leonard Nimoy als The Zarn (voice) |
 | Michael Papajohn als Astronaut (uncredited) |
 | Kiernan Shipka als Tar Pits Kid |
 | Dylan Sprayberry als Tar Pits Kid (uncredited) |
| Chris Henchy | Writer |
| Avy Kaufman | Casting |
| Bo Welch | Production Design |
| Josh Church | Producer |
| Marty Krofft | Producer |
| Sid Krofft | Producer |
| Brad Silberling | Director |
| Ryan Kavanaugh | Executive Producer |
| Michael Giacchino | Original Music Composer |
| Julie Darmody | Executive Producer |
| Adam McKay | Executive Producer |
| Dennis McNicholas | Writer |
| Peter Teschner | Editor |
| John Swallow | Producer |
| Daniel Lupi | Executive Producer |
| Jimmy Miller | Producer |
| Sid Krofft | Original Story |
| Marty Krofft | Original Story |
| Dion Beebe | Director of Photography |
| Brad Silberling | Executive Producer |
| Mark Bridges | Costume Design |
| Lauri Gaffin | Set Decoration |
| Sachin Bangera | Technical Supervisor |
| Sagar Patil | Visual Effects Art Director |
| Bill Westenhofer | Visual Effects Supervisor |
| Daniel Lupi | Unit Production Manager |
| Michele Panelli-Venetis | First Assistant Director |
| David Mendoza | Second Assistant Director |
| Doug Coleman | Stunt Coordinator |
| Will Weiske | Associate Producer |
| Will Weiske | Production Supervisor |
| Michele Panelli-Venetis | Associate Producer |
| Jessica Elbaum | Associate Producer |
| John Dexter | Supervising Art Director |
| Maya Shimoguchi | Art Direction |
| Kasra Farahani | Assistant Art Director |
| Lauren E. Polizzi | Assistant Art Director |
| Sam Page | Set Designer |
| Luis G. Hoyos | Set Designer |
| Sarah Contant | Set Designer |
| Zachary Fannin | Graphic Designer |
| Gabriel Hardman | Storyboard Artist |
| Richard Bloom | Art Department Coordinator |
| Scott Maginnis | Property Master |
| Anthony Carlino | Leadman |
| Mark Palmer | Set Dresser |
| Marco López | Set Dresser |
| Bruce Luizzi | Set Dresser |
| Nicholas Rymond | Set Dresser |
| Randy Severino | Set Dresser |
| Sion Michel | Camera Operator |
| E.J. Misisco | First Assistant "A" Camera |
| Michael Paul Jones | Second Assistant "A" Camera |
| Darin Moran | "B" Camera Operator |
| Paul Santoni | First Assistant "B" Camera |
| Andrew Degnan | Second Assistant "B" Camera |
| Michael Svitak | Camera Loader |
| Ralph Nelson Jr. | Still Photographer |
| Pud Cusack | Production Sound Mixer |
| Ross Simpson | Boom Operator |
| Ross Levy | Utility Sound |
| John Buckley | Chief Lighting Technician |
| Alfred Castillo | Best Boy Grip |
| Brad Rea | Dolly Grip |
| Dwayne Barr | Dolly Grip |
| Andy Nelson | Sound Re-Recording Mixer |
| Anna Behlmer | Sound Re-Recording Mixer |
| Richard King | Supervising Sound Editor |
| Michael Lantieri | Special Effects Supervisor |
| Steve Artmont | Makeup Department Head |
| Simone Almekias-Siegl | Key Makeup Artist |
| Bridget Cook | Hair Department Head |
| Nanci Cascio | Key Hair Stylist |
| Kimberly Adams | Assistant Costume Designer |
| Lynda Foote | Costume Supervisor |
| Cate Hardman | Script Supervisor |
| Claire Raskind | Unit Publicist |
| Carol Grant | Extras Casting |
| Robert A. Blackburn | Construction Coordinator |
| Kimberly Harris | ADR Supervisor |
| Laura Graham | ADR Editor |
| Hugo Weng | Dialogue Editor |
| Christopher Flick | Foley Supervisor |
| Robin Harlan | Foley Artist |
| Sarah Monat | Foley Artist |
| Randy Singer | Foley Mixer |
| Barbara Harris | ADR Voice Casting |
| Thomas J. O'Connell | ADR Mixer |
| Charleen Richards-Steeves | ADR Mixer |
| Rick Canelli | ADR Recordist |
| David Lucarelli | ADR Recordist |
| Steven J. Scott | Digital Intermediate Colorist |
| Curtis Lindersmith | Digital Intermediate Editor |
| Richard King | Sound Designer |
| Meegan E. Godfrey | Stunt Double |
| Ryan Biegel | Accounting Clerk Assistant |
