 | James C. Mathis III als T'Challa / Black Panther (voice) |
 | Keston John als Erik Killmonger (voice) |
 | Yvette Nicole Brown als Okoye (voice) |
 | Daisy Lightfoot als Shuri (voice) |
 | Isaac C. Singleton Jr. als Thanos (voice) |
 | Trevor Devall als Klaue (voice) |
 | Mick Wingert als Iron Man (voice) |
 | Fred Tatasciore als Hulk (voice) |
 | Laura Bailey als Black Widow (voice) / Reporter (voice) |
 | Roger Craig Smith als Captain America (voice) |
 | Travis Willingham als Thor (voice) / Parking Attendant (voice) |
 | Liam O'Brien als Doctor Strange (voice) |
| Stan Lee | Co-Executive Producer |
| Joe Quesada | Executive Producer |
| Michael D. Black | Director |
| Mark Hoffmeier | Writer |
| Joshua Wexler | Producer |
| Jason Cosler | Executive Producer |
| Kalia Cheng | Supervising Producer |
| Cort Lane | Executive Producer |
| Laura Jackloski | Associate Producer |
| Leslie Barker | Producer |
| Robert May | Executive Producer |
| Jill Wilfert | Executive Producer |
| Michael D. Black | Editor |
| Franck Louis-Marie | Art Direction |
| David Wurst | Music |
| Eric Wurst | Music |
| Jim Starlin | Characters |
| Andrii Starykovskyi | Foley Artist |
| Dan Buckley | Executive Producer |
