 | Keanu Reeves als Siddhartha |
 | Bridget Fonda als Lisa Conrad |
 | Chris Isaak als Dean Conrad |
 | Ruocheng Ying als Lama Norbu |
 | Alex Wiesendanger als Jesse Conrad |
| Raju Lal als Raju |
| Greishma Makar Sing als Gita |
 | Sogyal Rinpoche als Kenpo Tenzin |
| Khyongla Rato Rinpoche als Abbot |
| Geshe Tsultim Gyelsen als Lama Dorje |
 | Jo Champa als Maria |
| Jigme Kunsang als Champa |
| Bernardo Bertolucci | Director |
| Vittorio Storaro | Director of Photography |
| Pietro Scalia | Editor |
| Ryuichi Sakamoto | Original Music Composer |
| James Acheson | Production Design |
| Melissa Matthies | Property Master |
| Angelo Novi | Still Photographer |
| Bernardo Bertolucci | Story |
| Rudy Wurlitzer | Screenplay |
| Mark Peploe | Screenplay |
| Jeremy Thomas | Producer |
| Howard Feuer | Casting |
| Priscilla John | Casting |
| Fabrizio Sergenti Castellani | Casting |
| Gianni Giovagnoni | Art Direction |
| Andrew Sanders | Supervising Art Director |
| Steve Simmonds | Art Direction |
| Bruno Cesari | Set Decoration |
| Manohar Shrestha | Set Decoration |
| James Acheson | Costume Design |
| Lois Burwell | Assistant Makeup Artist |
| Robaire Charbonneau | Key Hair Stylist |
| Francesca Crowder | Hair Assistant |
| Peter Frampton | Makeup Department Head |
| Sian Grigg | Hair Assistant |
| Katharina Hirsch-Smith | Key Makeup Artist |
| Amanda Knight | Assistant Makeup Artist |
| Daniel Parker | Prosthetics |
| Martin Samuel | Hair Department Head |
| Suzanne Stokes-Munton | Wig Designer |
