 | Robert De Niro als Jack Byrnes |
 | Ben Stiller als Greg Focker |
 | Owen Wilson als Kevin Rawley |
 | Dustin Hoffman als Bernie Focker |
 | Barbra Streisand als Rozalin Focker |
 | Blythe Danner als Dina Byrnes |
 | Teri Polo als Pam Byrnes-Focker |
 | Jessica Alba als Andi Garcia |
 | Laura Dern als Prudence |
 | Kevin Hart als Nurse Louis |
 | Daisy Tahan als Samantha Focker |
 | Colin Baiocchi als Henry Focker |
 | Tom McCarthy als Dr. Bob |
 | Harvey Keitel als Randy Weir |
 | Yul Vazquez als Junior |
 | Jack Axelrod als Chappy |
 | Clent Bowers als Mr. Androvsky |
 | Olga Fonda als Svetlana |
| Laksh Singh als Dr. Patel |
 | Trula M. Marcus als Stage Producer |
 | Jake Keiffer als Rufus |
 | Rob Huebel als Sleazy Doctor |
 | John DiMaggio als EMT |
 | Jordan Peele als EMT |
 | Kelli Kirkland als EMT |
 | Deepak Chopra als Deepak Chopra |
 | Robbie Tucker als EHS Tough Kid |
 | Nick Kroll als Young Doctor |
 | Sergio Calderón als Gustavo |
| Aaron Zachary Philips als Confused Child |
 | David Pressman als Doctor |
 | Hugh Dane als Doctor |
 | Amy Stiller als Kristen |
| Richard Cotovsky als Newspaper Vendor |
| Trinity Warren als Climbing Kid |
| Samuel Schultz als Climbing Kid |
| Cade Rogers als Climbing Kid / Bounce House Kid |
| Ava Rose Williams als Climbing Kid |
| Frankie Torres als Climbing Kid |
| Kyla Warren als Party Kid |
| Erin Haisan als Party Kid |
| Ryder Bucaro als Party Kid |
| Callder Griffith als Party Kid |
| Lei'lah Star als Party Kid |
| David Williams als Party Kid |
| Randy Chuang als Monk |
| Joe Thamawat als Monk |
| Harry Bali als Sadu |
 | Paul Herman als Caricature Artist |
| Leslie Garavito als Fire Pit Child |
| Cort Rogers als Bounce House Kid |
| Troy Lindsay Brown als Bounce House Kid |
| Erika Jensen als Party Parent |
 | Robert Miano als Party Parent |
| Kat Kramer als Party Parent |
 | Roy Jones Jr. als Party Parent |
| Derek Ressallat als Party Parent |
 | Vladimir Kubr als Ballpit Kid |
| Semere-Ab Etmet Yohannes als Fire Walker |
| Nicole Pano als Art Teacher |
 | Michael Naughton als Anatomy Professor |
| Celina Zambón als Carmencita |
| Shih Chou als Party Monk |
 | Stan Egi als Man on Subway |
| Juan Antonio Bolivar als Flamenco Dancer |
 | Michelle Castillo als Flamenco Dancer |
| Theo Crisell als Flamenco Dancer |
| Neisha Folkes-LeMelle als Flamenco Dancer |
 | Jillana Laufer als Flamenco Dancer |
| Molly Rogers als Flamenco Dancer |
 | Gary Sievers als Spanish Square Patron (uncredited) |
 | Arnold Chon als Monk (uncredited) |
| Paul Weitz | Director |
| Jane Rosenthal | Producer |
| John Hamburg | Producer |
| Robert De Niro | Producer |
| Jay Roach | Producer |
| John Hamburg | Writer |
| Larry Stuckey | Writer |
| John Isaacs | Hair Department Head |
| Stephen Trask | Original Music Composer |
| Remi Adefarasin | Director of Photography |
| Leslie Jones | Editor |
| Myron Kerstein | Editor |
| Joseph Middleton | Casting |
| Molly Maginnis | Costume Design |
| Greg Hayden | Editor |
| William Arnold | Production Design |
| Daniel Lupi | Executive Producer |
| Meghan Lyvers | Executive Producer |
| Andrew Miano | Executive Producer |
| Nancy Tenenbaum | Executive Producer |
| Ryan Kavanaugh | Executive Producer |
| Greg Glienna | Characters |
| Mary Ruth Clarke | Characters |
| Garrett Warren | Stunt Coordinator |
| Daniel Lupi | Unit Production Manager |
| Katterli Frauenfelder | First Assistant Director |
| Gary Marcus | First Assistant Director |
| Paula Case | Second Assistant Director |
| Will Weiske | Production Supervisor |
| Sue Chan | Supervising Art Director |
| Thomas T. Taylor | Art Direction |
| Barbara Mesney | Set Designer |
| Clint Schultz | Graphic Designer |
| Jennifer R. Blair | Art Department Coordinator |
| Jim Magdaleno | Storyboard Artist |
| Todd Ellis | Property Master |
| Allison Gross | Assistant Property Master |
| David Smith | Set Decoration |
| Richard Brunton | Leadman |
| Glen Wilson | Still Photographer |
| Brenner Harris | Set Dresser |
| Kelly Schultz | Set Dresser |
| Michael Thurman | Set Dresser |
| John Bratton | Set Dresser |
| Samuel J. Tell | Set Dresser |
| Perry Batchelor | Set Dresser |
| Jay M. Huntoon | Video Assist Operator |
| P. Scott Sakamoto | Camera Operator |
| P. Scott Sakamoto | Steadicam Operator |
| Dennis Seawright | First Assistant Camera |
| Haydn Pazanti | Second Assistant Camera |
| David E. Diano | "B" Camera Operator |
| Clyde E. Bryan | First Assistant "B" Camera |
| Suzanne Trucks | First Assistant "B" Camera |
| Michael D. Alvarez | Second Assistant "B" Camera |
| Willie D. Burton | Production Sound Mixer |
| Gary A. Theard | Boom Operator |
| David Lee | Chief Lighting Technician |
| Ryan French | Assistant Chief Lighting Technician |
| Kevin J. Lang | Rigging Gaffer |
| Jack Chouchanian | Key Grip |
| Jimmy Culligan | Best Boy Grip |
| Pete Asidilla | Dolly Grip |
| Troy N. Wade | Dolly Grip |
| Jeff Kunkle | Dolly Grip |
| Reginald Donaldson | Grip |
| Steven Hubbell | Grip |
| Diego Mariscal | Grip |
| Ryan Nelson | Grip |
| Michael Lantieri | Special Effects Supervisor |
| Eden Clark Coblenz | Costume Supervisor |
| Nanrose Buchman | Assistant Costume Designer |
| Steve Artmont | Makeup Department Head |
| Annie Welles | Script Supervisor |
| Stephen P. Del Prete | Second Second Assistant Director |
| Katterli Frauenfelder | Associate Producer |
| Demelza Cronin | Production Coordinator |
| Colleen Gibbons | Location Manager |
| Pamela S. Westmore | Makeup Artist |
| Kate Biscoe | Makeup Artist |
| Patty York | Makeup Artist |
| David DeLeon | Makeup Artist |
| Tricia Sawyer | Makeup Artist |
| Lori Guidroz | Hairstylist |
| Geraldine Jones | Hairstylist |
| Barbara Lorenz | Hairstylist |
| Janine Rath-Thompson | Hairstylist |
| Garrett Warren | Second Unit Director |
| Corey Sklov | Assistant Production Coordinator |
| Justin R. Williams | Production Secretary |
| Maura Gannett | Studio Teacher |
| Rachel E. Prentiss | Production Accountant |
| Gail Rose | Post Production Accountant |
| Kimberly Aguirre | Payroll Accountant |
| Tineka Becker | Casting Associate |
| Katie Calogero | Casting Assistant |
| Carol Grant | Extras Casting |
| Carol McConnaughey | Unit Publicist |
| Dave DeGaetano | Construction Coordinator |
| Steven Rigamat | Construction Foreman |
| Paul E. Stroh | Transportation Coordinator |
| George Nadian | Transportation Captain |
| Jimmy Ray Pickens | Transportation Co-Captain |
| Jon Taylor | Sound Re-Recording Mixer |
| Bob Beemer | Sound Re-Recording Mixer |
| Frank Cuomo | Post Production Supervisor |
| James Andrykowski | First Assistant Editor |
| Eric Lindemann | Supervising Sound Editor |
| Eric Lindemann | Sound Designer |
| Stephanie Flack | ADR Supervisor |
| Christopher Alba | Foley Supervisor |
| Barbara Harris | ADR Voice Casting |
| Paul Hackner | Sound Effects Editor |
| Bill R. Dean | Sound Effects Editor |
| David A. Whittaker | Sound Effects Editor |
| Mark Larry | Sound Effects Editor |
| Julie Feiner | ADR Editor |
| Mike Szakmeister | Dialogue Editor |
| Cameron Steenhagen | Dialogue Editor |
| Marla McGuire | Foley Editor |
| Matthew W. Kielkopf | Assistant Sound Editor |
| Dan O'Connell | Foley Artist |
| John T. Cucci | Foley Artist |
| James Ashwill | Foley Mixer |
| Richard Duarte | Foley Mixer |
| Thomas J. O'Connell | ADR Mixer |
| Rick Canelli | ADR Recordist |
| Amanda Goodpaster | Music Editor |
| Natasha Leonnet | Digital Intermediate Colorist |
| Alicia Johnson | Digital Intermediate Producer |
| Cheryl Cravedi | Set Costumer |
| Kelly Bellini | Stunt Double |
| Kelli Barksdale | Stunts |
| Alicia Vela-Bailey | Stunts |
| Natalie M. Meyer | Utility Stunts |
| Marie Fink | Stunts |
| Alex Betuel | Set Production Assistant |
