 | Scarlett Johansson als Lucy Miller |
 | Morgan Freeman als Professor Samuel Norman |
 | Choi Min-sik als Mr. Jang |
 | Amr Waked als Pierre Del Rio |
 | Julian Rhind-Tutt als The Limey |
 | Pilou Asbæk als Richard |
 | Lio Tipton als Caroline |
 | Shin Yoo-ram als Jang's Lieutenant |
 | Seo Chong-ju als Jang's Lieutenant |
 | Nicolas Phongpheth als Jii |
 | Paul Lefèvre als French Mule |
 | Jan Oliver Schroeder als German Mule |
 | Luca Angeletti als Italian Mule |
 | Pierre Poirot als Professor |
 | Pierre Grammont als Professor |
| Bertrand Quoniam als Professor |
 | Loïc Brabant als Professor |
 | Pascal Loison als Drug Addict |
| Pierre Gérard als Airport Doctor |
 | Isabelle Cagnat als Airport Nurse |
 | Frédéric Chau als Cabin Manager |
 | Claire Tran als Flight Attendant |
 | François Legrand als Business Man Plane |
 | Bob Martet als Customs Officer |
| Alexis Rangheard als Cop Robert |
 | Tonio Descanvelle als Cop Sergeant |
 | Julien Personnaz als Cop |
| Christophe Lavalle als Cop |
| Renaud Cestre als Student |
| Thibault Segouin als Student |
| Matthew Bravais als Student |
| Claire Zaniolo als Student |
| Alessandro Giallocosta als Marco Brezzi |
 | Wolfgang Pissors als Berlin Custom Officer |
| Sifan Shao als Chinese Doctor |
 | Paul Chan als Taipei Surgeon |
| Chou Chung-Wei als Jang's Man |
| Huan Jhih-Cyuan als Jang's Man |
| I. Cheng-Sheng als Jang's Man |
| Frank Ma als Jang's Man |
| Tseng Sheng-En als Jang's Man |
| Liu Hsieh-Min als Mahjong Room Man |
| Sandra Abouav als Prehistoric Lucy |
 | Abel Aboualiten als Prehistoric Man |
 | Ken Lin als Regent Hotel Concierge #1 |
| Hsing Feng als Lucy's Driver |
| Hao-Hsiang Hsu als Warehouse Man Driver |
| Laura D'Arista als Lucy's Mother (voice) |
| Eunyul Hong als Phone Voice Royal Suite (voice) |
 | Samuel Churin als The Receptionist |
 | Mason Lee als Regent Hotel Concierge #2 |
| Mohammad Aslam Ansari als Fakir |
| Kevin Dust als American Native Indian |
| Diego Llano als American Native Indian |
| Timothy Reevis als American Native Indian |
| Jaysson Reyes De La Cruz als American Native Indian |
| German Tintaya Mamani als American Native Indian |
| Kanneti Sawe Han als Rubik's Cube Boy |
 | Cédric Chevalme als Cop Daniel |
| Luc Besson | Director |
| Luc Besson | Writer |
| Virginie Besson-Silla | Producer |
| Marc Shmuger | Executive Producer |
| Nathalie Chéron | Casting |
| Hugues Tissandier | Production Design |
| Gilles Boillot | Art Direction |
| Dominique Moisan | Art Direction |
| Stéphane Robuchon | Art Direction |
| Thierry Zemmour | Art Direction |
| Evelyne Tissandier | Set Decoration |
| Olivier Bériot | Costume Design |
| Christophe Chabenet | Sculptor |
| Charlie Clerc | Assistant Art Director |
| Anne-Sophie Delaunay | Assistant Art Director |
| Paulo Gonçalves | Assistant Art Director |
| Virginie Irdel | Assistant Art Director |
| Ben Mauro | Conceptual Design |
| Eduardo Pena | Conceptual Design |
| Guillaume Bouchateau | Supervising Sound Editor |
| Régis Boussin | Boom Operator |
| Matthieu Dallaporta | Dialogue Editor |
| Aymeric Devoldère | Sound Designer |
| Lionel Dousset | Boom Operator |
| Shannon Mills | Sound Designer |
| Jean-Christophe Magnaud | Special Effects Coordinator |
| Kevin Berger | Visual Effects Supervisor |
| Richard Bluff | Visual Effects Supervisor |
| Marie-Cecile Dahan | Visual Effects Producer |
| Valerie Delahaye | Visual Effects Producer |
| Simon Descamps | Visual Effects Producer |
| François Dumoulin | Visual Effects Supervisor |
| Brice Liesveld | Visual Effects Producer |
| James Pastorius | Visual Effects Supervisor |
| Gregory Fromentin | Gaffer |
| Samuel Potin | Music Editor |
| Adrien Adriaco | Location Manager |
| Isabelle Querrioux | Script Supervisor |
| Raimundo Querido | Stunts |
| Thierry Arbogast | Director of Photography |
| Éric Serra | Original Music Composer |
| Stéphane Robert | Makeup Artist |
| Florence Batteault | Makeup Artist |
| Marie Gombeaud-Antoine | Makeup Artist |
| Nathalie Regior | Makeup Artist |
| Marthe Faucouit | Makeup Artist |
| Anne Moralis | Wigmaker |
| Thierry Guilmard | Production Manager |
| Shannon Mills | Supervising Sound Editor |
| Guillaume Bouchateau | Sound Designer |
| Jeremy Bowker | Sound Effects Editor |
| Sébastien Jeannot | Sound Effects Editor |
| Matthieu Dallaporta | Sound Re-Recording Mixer |
| Didier Lozahic | Sound Re-Recording Mixer |
| Didier Lozahic | Editor |
| Sophie Leclerc | Visual Effects Producer |
| Ryan Wiederkehr | Visual Effects Producer |
| Daniel Perez Ferreira | CG Supervisor |
| Laurent Demianoff | Stunt Coordinator |
| Jean-Baptiste Jay | Camera Operator |
| Larry McConkey | Steadicam Operator |
| Lorenzo Donati | Steadicam Operator |
| Mark Gerasimenko | Helicopter Camera |
| Marion Gaillard | Additional Camera |
| Jessica Forde | Still Photographer |
| Marc Guidetti | Location Manager |
| Jérémy Petetin | Location Manager |
| Nour Rakotobe | Production Accountant |
| Todd Spears | Production Accountant |
| Aiden Ramos | Sound Recordist |
| Frédérique Foglia | Special Effects Makeup Artist |
| Sylvie Ferry | Special Effects Makeup Artist |
| Alain Villain | Stunt Driver |
| Virginie Arnaud | Stunt Driver |
| Eric Barone | Stunt Driver |
| Sybille Blouin | Stunt Driver |
| Alain Figlarz | Stunt Coordinator |
| Michelle Figlarz | Stunts |
| Pascaline Girardot | Stunt Driver |
| Yvonne Ho | Stunt Driver |
| Catherine Lebegue | Stunt Driver |
| Stéphane Lefebvre | Stunt Driver |
| Alice Naigeon | Stunt Driver |
| Alicia Vela-Bailey | Stunt Double |
| Stéphane Orsolani | Stunts |
| Marc Bizet | Stunts |
| Francis Bataille | Stunt Driver |
| Olivier Nguyen | Property Master |
| Guy Monbillard | Property Master |
| Julien Bachelier | Digital Imaging Technician |
| Amedéo Cazzella | Stunts |
