 | Tyler Posey als Inferno / Dante Pertuz (voice) |
 | Navia Robinson als Zayla (voice) |
 | Cierra Ramirez als America Chavez (voice) |
 | Kathreen Khavari als Kamala Khan / Ms. Marvel (voice) |
 | Milana Vayntrub als Squirrel Girl / Doreen Green (voice) |
 | Dove Cameron als Gwen Stacy / Ghost-Spider (voice) |
 | Dee Bradley Baker als Lockjaw / Tippy-Toe (voice) |
 | Gary Cole als Invisibilio (voice) |
 | Niecy Nash als Shocktress (voice) |
 | Jeannie Tirado als Gabriela / Teacher (voice) |
 | Meera Rohit Kumbhani als Ammi (voice) |
 | Tony Mirrcandani als Abu (voice) |
| Danielle Wolff | Writer |
| Greg Harman | Executive Producer |
| Dan Buckley | Executive Producer |
| Eric Radomski | Executive Producer |
| Kenneth T. Ito | Producer |
| Howard Schwartz | Producer |
| Kristopher Carter | Original Music Composer |
| Adam Redding | Editor |
| Amanda Goodbread | Casting |
| Sol Choi | Director |
| Joe Quesada | Executive Producer |
| Michael McCuistion | Original Music Composer |
| Lolita Ritmanis | Original Music Composer |
| Cort Lane | Executive Producer |
| Cheryl Cayetano | Associate Producer |
