 | Tommy Lee Jones als Agent K |
 | Will Smith als James Edwards / Agent J |
 | Linda Fiorentino als Dr. Laurel Weaver / Agent L |
 | Vincent D'Onofrio als Edgar / The Bug |
 | Rip Torn als Chief Zed |
 | Tony Shalhoub als Jack Jeebs |
 | Siobhan Fallon Hogan als Beatrice |
 | Mike Nussbaum als Gentle Rosenburg the Arquillian Jeweler |
 | Jon Gries als Van driver |
 | Sergio Calderón als Jose |
 | Carel Struycken als Arquillian |
 | Fredric Lehne als INS agent Janus |
 | Richard Hamilton als Agent D |
 | Kent Faulcon als 2nd Lt. Jake Jensen |
 | John Alexander als Mikey |
 | Keith Campbell als Perp |
 | Ken Thorley als Zap-Em Man |
 | Patrick Breen als Mr. Redgick |
 | Becky Ann Baker als Mrs. Redgick |
 | Sean Whalen als Passport Officer |
 | Harsh Nayyar als News Vendor |
 | Michael Willis als Cop in Morgue |
 | Willie C. Carpenter als Police Inspector |
 | Peter Linari als Tow Truck Driver |
 | David Cross als Morgue Attendant |
 | Charles C. Stevenson Jr. als MIB Agent Bee |
 | Boris Leskin als Cook |
 | Steve Rankin als INS Agent |
 | Andy Prosky als INS Agent |
| Michael Goldfinger als NYPD sergeant |
 | Alpheus Merchant als Security Guard |
| Norma Jean Groh als Mrs. Edelson |
| Bernard Gilkey als Baseball Player |
| Sean Plummer als First Contact Alien |
 | Michael Kaliski als First Contact Alien |
| Richard Arthur als 2nd First Contact Alien |
 | Debbie Lee Carrington als Alien Father |
 | Verne Troyer als Alien Son |
| Mykal Wayne Williams als Scared Guy |
 | Tim Blaney als Frank the Pug (voice) |
 | Mark Setrakian als Rosenberg Alien (voice) |
 | Brad Abrell als Worm Guy (voice) |
| Thom Fountain als Worm Guy (voice) |
| Carl J. Johnson als Worm Guy (voice) |
 | Drew Massey als Worm Guy (voice) |
| Christina Benitan als On-Air Reporter (uncredited) |
 | Lowell Cunningham als MiB HQ Office Worker (uncredited) |
 | Danny DeVito als Alien on TV Monitor (uncredited) |
 | John Elsen als NYPD Sergeant (uncredited) |
 | Newt Gingrich als Alien on TV Monitor (uncredited) |
 | Karen Lynn Gorney als Announcer (uncredited) |
 | Adrian Lee als Wall Street Broker (uncredited) |
 | George Lucas als Alien on TV Monitor (uncredited) |
 | Patricia McPherson als Spouse K (uncredited) |
 | Isaac Mizrahi als Alien on TV Monitor (uncredited) |
 | Fred Newman als Aliens (voice) (uncredited) |
| Joe Paparone als Police Inspector (uncredited) |
 | Tony Robbins als Alien on TV Monitor (uncredited) |
 | Al Roker als Alien on TV Monitor (uncredited) |
| Eliot Sash als Police Officer #4 (uncredited) |
| Marshal Silverman als Special Tech (uncredited) |
 | Barry Sonnenfeld als Alien on TV Monitor (uncredited) |
 | Chloe Sonnenfeld als Alien on TV Monitor (uncredited) |
 | Steven Spielberg als Alien on TV Monitor (uncredited) |
 | Dionne Warwick als Alien on TV Monitor (uncredited) |
| Debra Zane | Casting |
| Steven Spielberg | Executive Producer |
| Danny Elfman | Original Music Composer |
| Lawrence A. Hubbs | Set Designer |
| John Cameron | First Assistant Director |
| Eugene Gearty | Sound Effects Designer |
| Walter F. Parkes | Producer |
| Cheryl Carasik | Set Decoration |
| Florian Ballhaus | Camera Operator |
| Bo Welch | Production Design |
| Barry Sonnenfeld | Director |
| David Rubin | Casting |
| Tom Duffield | Art Direction |
| Donald Peterman | Director of Photography |
| Laurie MacDonald | Producer |
| Ken Schretzmann | Assistant Editor |
| Steve Lucescu | Transportation Co-Captain |
| Gino Acevedo | Painter |
| Ed Solomon | Screenplay |
| Lowell Cunningham | Comic Book |
| Jim Miller | Editor |
| Mary E. Vogt | Costume Design |
| Katherine James | Makeup Artist |
| Sean Haworth | Set Designer |
| Skip Lievsay | Supervising Sound Editor |
| Skip Lievsay | Sound Re-Recording Mixer |
| Tom Chesney | Special Effects |
| Peter Chesney | Special Effects Coordinator |
| Eric Brevig | Visual Effects Supervisor |
| Eric Brevig | Second Unit Director |
| Deborah Habberstad | Stunts |
| Jeff Habberstad | Stunts |
| Debbie Zoller | Makeup Artist |
| Tim Collins | Grip |
| David M. Dunlap | Second Unit Cinematographer |
| Stuart B. Hagen | Second Assistant Director |
| Rick Baker | Makeup Artist |
| Ellen Segal | Music Editor |
| Alexandra Altrocchi | Visual Effects Coordinator |
| Brian Smrz | Stunt Coordinator |
| Mark De Alessandro | Stunts |
| Chris Shriver | Art Direction |
| Maggie Morgan | Assistant Costume Designer |
| Patrick M. Sullivan | Set Designer |
| Graham Place | Unit Production Manager |
| Graham Place | Co-Producer |
| Denise Doyle | Production Assistant |
| Jacqui Lopez | Visual Effects Producer |
| Van Ling | Sound Designer |
| Susan Ringo | Thanks |
| Steve Bartek | Orchestrator |
| Stephen St. John | Camera Operator |
| Steve Reinhardt | Assistant Chief Lighting Technician |
| Gene Harrison | Stunt Driver |
| J. Todd Anderson | Storyboard Artist |
| Chuck Michael | Sound Designer |
| Pierce Austin | Hairstylist |
| Artie Kane | Conductor |
| Ellen Christiansen | Set Decoration |
| Mark McKenzie | Orchestrator |
| Marco Rubeo | Set Designer |
| Richard Brooks Burton | Aerial Camera |
| Kam Chan | Foley Editor |
| Benjamin Cheah | Foley Supervisor |
| Marko Costanzo | Foley Artist |
| Lee Dichter | Sound Re-Recording Mixer |
| Lewis Goldstein | Sound Effects Editor |
| Marissa Littlefield | Supervising ADR Editor |
| Todd Milner | Assistant Sound Editor |
| David Golia | Camera Operator |
| Tyree Michael Simpson | Production Assistant |
| Ann Carli | Executive Music Producer |
| Peter Kuran | Visual Effects |
| Shawn Murphy | Scoring Mixer |
| Mai Iskander | Assistant Camera |
| Scott Maginnis | Assistant Property Master |
| John Fundus | Boom Operator |
| John Leonidas | Transportation Captain |
| Peter Ramsey | Storyboard Artist |
| Whitey Hughes | Stunts |
| Peter F. Kurland | Production Sound Mixer |
| Scott P. Murphy | Assistant Art Director |
| Derek Thompson | Creature Design |
| Rick Wentworth | Conductor |
| Denise Ream | Visual Effects Producer |
| Bruce White | Musician |
| Christian Zimmermann | Standby Painter |
| Liz Radley | CG Supervisor |
| Alyson Silverberg | Extras Casting Coordinator |
| Christian Clarke | Production Assistant |
| Jeff Murrell | Chief Lighting Technician |
| Stracy Diaz | Utility Stunts |
| Kia Steave-Dickerson | Set Dresser |
| Sally Stevens | Playback Singer |
| Scott Mitchell Rosenberg | Thanks |
| Matthew Gratzner | Prop Designer |
| Jane E. Russell | Unit Publicist |
| Matt Rose | Sculptor |
| Frank Kern | Foley Editor |
| Daniel Fisher | Assistant Property Master |
| Melinda Sue Gordon | Still Photographer |
| Dan Bronson | Costume Supervisor |
| Paul Guyot | Stand In |
| Michael Barry | Sound Re-Recording Mixer |
| Denny Caira | Transportation Captain |
| Doug Harlocker | Property Master |
| Scott Farrar | Visual Effects Supervisor |
| Pablo Ferro | Title Designer |
| Jac Rubenstein | Foley Editor |
| Bob Moore Jr. | Set Costumer |
| Russell Engels | Gaffer |
| Mary Bailey | Script Supervisor |
| Glenfield Payne | Assistant Sound Editor |
| Kurt E. Soderling | Visual Effects Camera |
| David Nakabayashi | Visual Effects Art Director |
| Mitch Devane | Sculptor |
| Jonathan Harb | Concept Artist |
| Mike Koz | Assistant Editor |
| Becky Brake | Assistant Location Manager |
| Michael Diersing | Construction Coordinator |
| David Manhan | Leadman |
| Kazu Hiro | Sculptor |
| Lisa D. DiSanto | Production Assistant |
| Keith Peterman | Second Unit Cinematographer |
| Laini Thompson | Makeup Artist |
| Brent Boates | Storyboard Artist |
| Robbie Goldstein | Location Manager |
| John Branagan | Stunts |
| Gregg Smrz | Stunt Coordinator |
| Jim McPherson | Sculptor |
| Timothy Eaton | Visual Effects Editor |
| Rob Coleman | Animation Supervisor |
| Gregory W. Smith | Camera Operator |
| Amy Ness | Production Supervisor |
| Eddie Yang | Sculptor |
| Howard London | ADR Mixer |
| Todd Boyce | CG Animator |
| Marcia Patten | Wardrobe Supervisor |
| Carl N. Frederick | Digital Effects Supervisor |
| Karen Rasch | First Assistant Editor |
| Chris Soldo | Second Unit First Assistant Director |
| Steven R. Molen | Associate Producer |
| David Rowden | Stunts |
| Tim Norman | Second Assistant Camera |
| Tyrone S. Walker | Additional Second Assistant Director |
| Cara Giallanza | Second Unit First Assistant Director |
| Bobby Mackston | Supervising Dialogue Editor |
| J. Ellen Evans | Script Supervisor |
| William T. Jones | Rigging Grip |
| Gerald Solomon | Hairstylist |
| Margaret B. Lynch | Visual Effects Coordinator |
| Virginia G. Hadfield | Key Hair Stylist |
| Bob Finley III | Gaffer |
| Richard J. Cook | Digital Effects Producer |
| Moto Hata | Sculptor |
| Zoran Veselic | Steadicam Operator |
| Peter Gelfman | Property Master |
| Pilar McCurry | Music Supervisor |
| Benton Jew | Creature Design |
| John Andrew Berton Jr. | Digital Effects Supervisor |
| Robert Marinic | Digital Effects Supervisor |
| Kyle Ross Collinsworth | Special Effects Supervisor |
| Michael Caracciolo | Camera Operator |
| Ken Connors | Rigging Gaffer |
| Martin Lowry | Key Rigging Grip |
| Jay Peterman | First Assistant Camera |
| Gerard Sava | First Assistant Camera |
| Mark Gutterud | First Assistant Camera |
| Danielle Feller | Set Costumer |
| Norm MacLeod | Dialogue Editor |
| Rick Freeman | Sound Effects Editor |
| John Bartle | Assistant Editor |
| Michael F. Burke | Best Boy Electric |
| David H. Kramer | ADR Voice Casting |
| Donald Murphy | Set Production Assistant |
| Michael B. Bunch | Construction Foreman |
| Mauriece Jacks Jr. | Video Assist Operator |
| Bill Barr | Key Grip |
| Gabriela Vázquez | Second Assistant Director |
| Diane Pepper | Hairstylist |
| John G. McCabe | Special Effects |
| James Carson | Production Illustrator |
| Peter A. Mian | Video Assist Operator |
| Bruce Pross | Foley Mixer |
| Gail Martin-Sheridan | Production Accountant |
| Anthony Veader | Hairstylist |
| Richard Castro | Payroll Accountant |
| Bob Putynkowski | Color Timer |
| Jason H. Snell | Visual Effects Production Assistant |
| Carlo Basail | Greensman |
| Jamie Kehoe | Craft Service |
| Jose Fernandez | Sculptor |
| J.D. Streett | Special Effects |
| Hank Mayo | Conceptual Design |
| James Bartolomeo | Second Assistant Camera |
| Mike Currie | Set Production Assistant |
| Timothy Metzger | Leadman |
| Tommy Louie | Cableman |
| Carl Rydlund | Musician |
| Mo Henry | Negative Cutter |
| Jen Kinavey | Visual Effects Production Assistant |
| Dennis Gamiello | Key Grip |
| Jesse Mather | Lighting Technician |
| Henry Antonacchio | Construction Foreman |
| T. Sean Ferguson | Second Assistant Director |
| Colin MacLellan | Production Assistant |
| Audie Aragon | Dolly Grip |
| Dennis Radesky | Transportation Co-Captain |
| Eric M. Metzger | Set Dressing Artist |
| Dick Dova | Grip |
| James Frederick | Electrician |
| Randy Sokol | Location Manager |
| Carol Neilson | Stunts |
| Steve Bowerman | Boom Operator |
| Sam Rohn | Location Scout |
| Calvin Sterry | Key Grip |
| Louis J. Porzio | Carpenter |
| Gregory Dultz | Driver |
| Travis Huffman | Propmaker |
| Dana Williams | Production Coordinator |
| Jeff Pierce | I/O Supervisor |
| Tammy R. Dickson | Production Assistant |
| Clifford Happy | Stunt Double |
| Reginald F. Lake | Chief Lighting Technician |
| Michael Lee Phillips Jr. | Production Assistant |
| Paul Plannette | Second Assistant Camera |
| Tammy L. Smith | Extras Casting |
| Marjorie K. Chan | Key Costumer |
| John Lowry | Dolly Grip |
| Edward W. Lowry | Dolly Grip |
| Colin Cumberbatch | Assistant Production Coordinator |
| Don Williams | Musician |
| Michael Anderson | Best Boy Grip |
| Daniel E. Teaze | Second Assistant Camera |
| Oren Marshall | Musician |
| Brian Fitzsimons | Best Boy Grip |
| Tommy Boyer | Wardrobe Supervisor |
| Doug Jones | Negative Cutter |
| Randolph LeRoi | Stunts |
| Michael Olague | Gaffer |
| Peter Hollocker | Production Assistant |
| Aaron Sims | Sculptor |
| Eric L. Roberts | Video Assist Operator |
| Nori Honda | Prosthetics Sculptor |
| Eric Amundsen | Second Assistant Camera |
| Louis Katz | Concept Artist |
| Denise Leibee | Hairstylist |
| Barry Rosenberg | Hairstylist |
| Steven Lawrence | Makeup Artist |
| Dodi Lee Rubenstein | Second Second Assistant Director |
| Paul Byrne Prenderville | Second Second Assistant Director |
| James R. Powers | Construction Foreman |
| Chris Zimmerman | Standby Painter |
| Thomas Thoms | Cableman |
| Louise Di Tullio | Musician |
| Thomas Gilliland | Painter |
| Ryan Peterson | Sculptor |
| Joe Heffernan | Special Effects |
| Roland Loew | Special Effects |
| Peter A. Renard | Special Effects |
| Shannon J. Thompson | Special Effects |
| Jon Thackery | Special Effects |
| Roderic Duff | Special Effects |
| Steven Carlton Ficke | Special Effects |
| Joel P. Blanchard | Special Effects Technician |
| Christian Eubank | Special Effects Technician |
| Karl Nettmann | Special Effects |
| Cristie Miele | Animal Wrangler |
| Ronald R. Koch Jr. | Assistant Chief Lighting Technician |
| Alex Cohn | Assistant Location Manager |
| Jamie Daddio | Assistant Production Coordinator |
| George W. Borthwick | Best Boy Grip |
| Michelle Levi | Casting Assistant |
| Susan Stolar | Casting Assistant |
| Joe Facey | Craft Service |
| Judie Fixler | Extras Casting |
| Bill Slemmons | Key Grip |
| Travis Harrod | Production Assistant |
| Courtney Henley-Anderson | Production Assistant |
| Randol Perelman-Taylor | Production Assistant |
| Rebecca Stefan | Production Assistant |
| George N. Thomas | Production Assistant |
| Brandon Wainwright | Production Assistant |
| Missy Barshay | Production Assistant |
| Tom Just | Production Assistant |
| Julia Morgan | Production Assistant |
| Jonathan R. O'Hara | Production Assistant |
| Steven P. Petyerak | Production Assistant |
| Stephanie F. Johnson | Production Assistant |
| Jennifer Reiss | Production Assistant |
| Ellen M. Hillers | Production Coordinator |
| Shannon Speaker | Production Secretary |
| Steve Craft | Second Assistant Camera |
| David Menapace | Transportation Captain |
| Carl Assmus | Grip |
| Bernie Demolski | Grip |
| Tad Leckman | Visual Effects Production Manager |
| Erica Kissack | Contact Lens Technician |
| Donovan C. Howard | Apprentice Sound Editor |
| Dustin DuPilka | Assistant Foley Artist |
| Don Gillespie | Assistant Accountant |
| Brian Griffin | Digital Supervisor |
| Joseph S. Alfieri | Construction Coordinator |
