 | Jared Leto als Dr. Michael Morbius / Morbius |
 | Matt Smith als Milo / Lucien |
 | Adria Arjona als Martine Bancroft |
 | Jared Harris als Dr. Emil Nicholas |
 | Al Madrigal als Agent Alberto Rodriguez |
 | Tyrese Gibson als Agent Simon Stroud |
 | Zaris-Angel Hator als Anna |
 | Joe Ferrara als Bush Pilot |
 | Charlie Shotwell als Young Michael |
 | Joseph Esson als Young Milo |
 | Jason Rennie als Ringleader Bully |
 | Aryan Moaven als Gang Member |
| Christopher Louridas als Gang Member |
 | Oliver Bodur als Gang Member |
 | Tom Forbes als Finance Bro (pub) |
 | Clara Rosager als Jean (pub) |
 | Corey Johnson als Mr. Fox |
 | Rolan Bell als Private Security Professional |
 | Bentley Kalu als Private Security Professional |
 | Joanna Burnett als Nurse Kristen Sutton |
 | Archie Renaux als Bobby |
 | Fermin Galeano als Bodega Owner |
 | Maia Scalia als Diner Cashier |
 | Jojo Macari als Gabriel |
 | Abraham Popoola als Ryan |
 | Adam El Hagar als Beat Cop |
 | Apphia Campbell als ESU Officer (Detention Center) |
 | Barry Aird als Newspaper Vendor |
 | Kalle Hennie als Norwegian Bodyguard |
 | Chris Ryman als Officer Dyson |
 | Jay Gomez-Adams als Construction Worker |
 | Michael Keaton als Adrian Toomes / Vulture |
 | Robert Ryan als Kite Flyer (uncredited) |
| Daniel Espinosa | Director |
| Avi Arad | Producer |
| Matt Tolmach | Producer |
| Lucas Foster | Producer |
| Oliver Wood | Director of Photography |
| Stefania Cella | Production Design |
| Gary Powell | Stunt Coordinator |
| Matt Gendron | Art Direction |
| James Lewis | Art Direction |
| Matt Sazama | Screenplay |
| Burk Sharpless | Screenplay |
| Jon Ekstrand | Original Music Composer |
| Louise Rosner-Meyer | Executive Producer |
| Emma Ludbrook | Executive Producer |
| Burk Sharpless | Screenstory |
| Matt Sazama | Screenstory |
| Pietro Scalia | Editor |
| Cindy Evans | Costume Design |
| Tina Jones | Set Decoration |
| Louise Young | Makeup Artist |
| Jane Harwood | Assistant Art Director |
| Fred M. Ortiz | Set Dresser |
| Shamim Seifzadeh | Set Designer |
| Beau Borders | Sound Re-Recording Mixer |
| Per Hallberg | Supervising Sound Editor |
| Paul Massey | Sound Re-Recording Mixer |
| Ann Scibelli | Sound Designer |
| Randy Torres | Sound Designer |
| Holly Freeman | Costume Supervisor |
| Travis Baumann | VFX Artist |
| Joel Behrens | Visual Effects Supervisor |
| Yoshi DeHerrera | Visual Effects Supervisor |
| Joseph DiValerio | VFX Artist |
| Victoria Keeling | Visual Effects Producer |
| Eric Kimelton | Visual Effects Producer |
| Jakob Lundbye | VFX Artist |
| Louis Mackall | Visual Effects Supervisor |
| Jared Leto | Executive Producer |
| Nina Gold | Casting |
| Matthew E. Butler | Visual Effects Supervisor |
| Louise Rosner-Meyer | Unit Production Manager |
| Toby Ford | First Assistant Director |
| Barry St. John | Co-Producer |
| Pietro Scalia | Associate Producer |
| Beni Hardiman | Associate Producer |
| Gary Powell | Second Unit Director |
| Adam Byles | Second Assistant Director |
| Victoria Zalin | Production Supervisor |
| Nigel Evans | Supervising Art Director |
| Remo Tozzi | Art Direction |
| Rachel Aulton | Art Direction |
| Gary Lock | Property Master |
| Jo Beckett | Script Supervisor |
| Graham Hall | "A" Camera Operator |
| Dave Hamilton-Green | "B" Camera Operator |
| Dave Hamilton-Green | Steadicam Operator |
| Sebastian Barraclough | "C" Camera Operator |
| Paul Wheeldon | First Assistant "A" Camera |
| Robert Palmer | First Assistant "B" Camera |
| Brad Larner | First Assistant "C" Camera |
| Dan Gamble | Second Assistant "A" Camera |
| Dean Morrish | Second Assistant "B" Camera |
| Oliver Squire | Second Assistant "C" Camera |
| Aisha Kascioglu | Assistant Costume Designer |
| Nina Jagersbacher | Assistant Costume Designer |
| Harriet Hundertmark | Costume Coordinator |
| Kasia Chojnowska | Tailor |
| Davina Greening | Seamstress |
| Jeremy Woodhead | Makeup Designer |
| Jeremy Woodhead | Hair Designer |
| Pat Sweeney | Gaffer |
| Tamsin Dorling | Makeup & Hair |
| Robb Crafer | Makeup & Hair |
| Conor O'Sullivan | Prosthetic Supervisor |
| Colin Shulver | Prosthetic Designer |
| Dominic Hailstone | Prosthetic Designer |
| Andy Hunt | Prosthetics Sculptor |
| Charlie Hounslow | Prosthetic Makeup Artist |
| Martin Conway | Best Boy Electric |
| Callum Collins | Electrician |
| Seth Crosby | Electrician |
| Ross Grimshaw | Electrician |
| Tom Hyde | Electrician |
| James Nesbitt | Electrician |
| Garry Thomson | Electrician |
| David Maund | Key Grip |
| Dan Garlick | Best Boy Grip |
| Simon Thorpe | Dolly Grip |
| Jack Glascodine | Grip |
| Pete Steward | Standby Carpenter |
| Callum Watson | Standby Rigger |
| Hannah Storm Miles | Standby Painter |
| Colin Nicolson | Production Sound Mixer |
| Colin Gregory | Boom Operator |
| Thayna McLaughlin | Second Assistant Sound |
| Keith Dawson | Special Effects Supervisor |
| Eleri Coulten | Location Manager |
| Lee Robertson | Location Manager |
| Dan Connolly | Location Manager |
| Karin Kavanagh | Location Coordinator |
| Charlotte Hemsley | Assistant Location Manager |
| Ben White | Assistant Location Manager |
| Leon Seth | Assistant Location Manager |
| Amelia Southgate | Production Coordinator |
| Ellie Coverdale | Assistant Production Coordinator |
| Matthew Ellis | Production Secretary |
| Thomas Kingett | Unit Manager |
| Frances Richardson | First Assistant Accountant |
| Miguel Pariente | Production Accountant |
| Harmeek Singh Sandall | Payroll Accountant |
| Grace Heath | Assistant Accountant |
| Stuart Watson | Construction Manager |
| Agis Pyrlis | Draughtsman |
| Gareth Sprey | Draughtsman |
| Cassandra Virdee | Draughtsman |
| Katherine Pearl | Art Department Coordinator |
| Ferenc Nothóf | Storyboard Artist |
| Robert Consing | Storyboard Artist |
| Dwayne Turner | Storyboard Artist |
| Sophia Chowdhury | Assistant Set Decoration |
| Daniel Vincze | Assistant Set Decoration |
| Ellie Pash | Assistant Set Decoration |
| Sophie Worley | Set Decorating Coordinator |
| Neil Floyd | Graphic Designer |
| Calle Tidbeck | Concept Artist |
| Mark Robson | Scenic Artist |
| Jonny Mellor | Scenic Artist |
| John Byrne | Thanks |
| Steve Ditko | Thanks |
| Gil Kane | Thanks |
| Howard Mackie | Thanks |
| Doug Moench | Thanks |
| Humberto Ramos | Thanks |
| Dan Slott | Thanks |
| Roy Thomas | Thanks |
| George Tuska | Thanks |
| Katherine McCormack | Unit Publicist |
| Jay Maidment | Still Photographer |
| James Excell | Third Assistant Director |
| Martin Ware | Casting Associate |
| Sacha Garrett | Casting Assistant |
| Ben Rothwell | Armorer |
| Liam McCartney | Armorer |
| Barrie Williams | Transportation Captain |
| Laurence Johnson | First Assistant Editor |
| James Barham | First Assistant Editor |
| Montrice White | Assistant Editor |
| John C. Stuver | Dialogue Editor |
| Franck Méndez | Assistant Editor |
| Mitchell J. Glaser | Visual Effects Editor |
| Peter Staubli | Additional Sound Re-Recording Mixer |
| David Giammarco | Additional Sound Re-Recording Mixer |
| David Werntz | Sound Designer |
| Stephen P. Robinson | Sound Designer |
| Daniel S. Irwin | Supervising ADR Editor |
| Daniel S. Irwin | Supervising Dialogue Editor |
| Philip D. Morrill | Assistant Sound Editor |
| Michelle Pazer | ADR Editor |
| Karen Baker Landers | Foley Supervisor |
| D. Chris Smith | Foley Editor |
| Adam DeCoster | Foley Artist |
| Randy Singer | Foley Mixer |
| Aaron Hasson | ADR Mixer |
| Richard Whelan | Second Unit First Assistant Director |
| Tim Wooster | Second Unit Director of Photography |
| Laura Bagano | Craft Service |
| Stephen Nakamura | Digital Colorist |
| Stan Lee | Thanks |
| Mallory Thompson | Stunt Double |
| Alexander H. Gayner | First Assistant Director |
| Rob Bliss | Concept Artist |
| Faye Green | Special Effects Coordinator |
| Elia P. Popov | Special Effects |
| Andrew James Bleidner | Stunt Double |
| Rachelle Beinart | Stunts |
| Benjamin Ashley | Stunts |
| Paul Bailey | Stunt Driver |
| Scott Burik | Stunt Driver |
| Stephanie Carey | Stunt Driver |
| Aidan Brindle | Stunt Driver |
| Marvin Campbell | Stunts |
| Terry Cade | Stunts |
| Matt Da Silva | Stunts |
| Adam Collins | Stunts |
| Douglas Crosby | Stunt Coordinator |
| Dom Dumaresq | Stunts |
| Sebastian Foxx | Stunts |
| Sergei Dmitriev | Stunts |
| Thomas Forbes-Johnson | Stunts |
| Sam Durrani | Utility Stunts |
| Paul Ginns | Stunts |
| Luke Gomes | Stunts |
| Sofian Francis | Stunts |
| Al Holland | Stunts |
| Dan Griffiths | Stunts |
| Mike Gunther | Stunt Coordinator |
| Cristian Knight | Stunts |
| Xavier Lake | Stunts |
| Sarah Lochlan | Stunts |
| Richard Leggett | Stunts |
| George Kirby | Stunt Double |
| Chris Morrison | Stunts |
| Paul Lowe | Stunts |
| Christina Low | Stunts |
| Theo Morton | Stunts |
| Steven Mullins | Stunts |
| Peter Miles | Stunt Coordinator |
| James O'Daly | Stunt Double |
| Vinny O'Brien | Stunt Double |
| Dave Phillips | Stunts |
| Laurent Plancel | Stunt Double |
| Tomás Paredes | Stunts |
| Louis Samms | Stunts |
| Rashid Phoenix | Stunts |
| Curtis Rowland Small | Stunts |
| Matt Sherren | Stunt Double |
| Blake Sporne | Stunts |
| Robbie P Smith | Stunt Driver |
| Roy Taylor | Fight Choreographer |
| Mens-Sana Tamakloe | Stunts |
| Pablo Verdejo | Stunts |
| Karen Teoh | Stunts |
| Greg Townley | Stunt Double |
| Nicolas Wang | Stunts |
| Jen Weissenberg | Utility Stunts |
| Calvin Warrington-Heasman | Stunts |
| Paul Weston | Stunts |
| Belle Williams | Stunts |
| Ramon Álvarez | Stunts |
| Victor Capoccia | Art Direction |
