 | Jared Leto als Dr. Michael Morbius / Morbius |
 | Matt Smith als Milo / Lucien |
 | Adria Arjona als Martine Bancroft |
 | Jared Harris als Dr. Emil Nicholas |
 | Al Madrigal als Agent Alberto Rodriguez |
 | Tyrese Gibson als Agent Simon Stroud |
 | Zaris-Angel Hator als Anna |
 | Joe Ferrara als Bush Pilot |
 | Charlie Shotwell als Young Michael |
| Joseph Esson als Young Milo |
| Jason Rennie als Ringleader Bully |
| Aryan Moaven als Gang Member |
| Christopher Louridas als Gang Member |
| Oliver Bodur als Gang Member |
 | Tom Forbes als Finance Bro (pub) |
 | Clara Rosager als Jean (pub) |
 | Corey Johnson als Mr. Fox |
| Rolan Bell als Private Security Professional |
 | Bentley Kalu als Private Security Professional |
| Joanna Burnett als Nurse Kristen Sutton |
 | Archie Renaux als Bobby |
| Fermin Galeano als Bodega Owner |
| Maia Scalia als Diner Cashier |
 | Jojo Macari als Gabriel |
 | Abraham Popoola als Ryan |
 | Adam El Hagar als Beat Cop |
| Apphia Campbell als ESU Officer (Detention Center) |
 | Barry Aird als Newspaper Vendor |
 | Kalle Hennie als Norwegian Bodyguard |
| Chris Ryman als Officer Dyson |
| Jay Gomez-Adams als Construction Worker |
 | Michael Keaton als Adrian Toomes / Vulture |
| Pietro Scalia | Editor |
| Pietro Scalia | Associate Producer |
| Jared Leto | Executive Producer |
| Steve Ditko | Thanks |
| Avi Arad | Producer |
| Jeremy Woodhead | Hair Designer |
| Jeremy Woodhead | Makeup Designer |
| Oliver Wood | Director of Photography |
| Lucas Foster | Producer |
| Per Hallberg | Supervising Sound Editor |
| Tina Jones | Set Decoration |
| Nina Gold | Casting |
| Cindy Evans | Costume Design |
| Louise Rosner-Meyer | Executive Producer |
| Louise Rosner-Meyer | Unit Production Manager |
| Paul Massey | Sound Re-Recording Mixer |
| Stefania Cella | Production Design |
| Sophia Chowdhury | Assistant Set Decoration |
| Daniel Espinosa | Director |
| Roy Thomas | Thanks |
| Beau Borders | Sound Re-Recording Mixer |
| Matt Tolmach | Producer |
| Robert Palmer | First Assistant "B" Camera |
| James Lewis | Art Direction |
| Jon Ekstrand | Original Music Composer |
| Matt Sazama | Screenplay |
| Matt Sazama | Screenstory |
| Burk Sharpless | Screenplay |
| Burk Sharpless | Screenstory |
| Pat Sweeney | Gaffer |
| Nigel Evans | Supervising Art Director |
| John Byrne | Thanks |
| Emma Ludbrook | Executive Producer |
| Franck Méndez | Assistant Editor |
| Matthew E. Butler | Visual Effects Supervisor |
| Jay Maidment | Still Photographer |
| Joseph DiValerio | VFX Artist |
| John C. Stuver | Dialogue Editor |
| Dave Hamilton-Green | Steadicam Operator |
| Dave Hamilton-Green | "B" Camera Operator |
| Graham Hall | "A" Camera Operator |
| Ann Scibelli | Sound Designer |
| Gary Powell | Stunt Coordinator |
| Gary Powell | Second Unit Director |
| Jo Beckett | Script Supervisor |
| Ellie Pash | Assistant Set Decoration |
| Travis Baumann | VFX Artist |
| Frances Richardson | First Assistant Accountant |
| Lee Robertson | Location Manager |
| Robb Crafer | Makeup & Hair |
| Laurence Johnson | First Assistant Editor |
| Robert Consing | Storyboard Artist |
| Sophie Worley | Set Decorating Coordinator |
| Remo Tozzi | Art Direction |
| Katherine Pearl | Art Department Coordinator |
| Martin Ware | Casting Associate |
| Paul Wheeldon | First Assistant "A" Camera |
| Brad Larner | First Assistant "C" Camera |
| Charlie Hounslow | Prosthetic Makeup Artist |
| Sebastian Barraclough | "C" Camera Operator |
| Ross Grimshaw | Electrician |
| Ben Rothwell | Armorer |
| Tamsin Dorling | Makeup & Hair |
| Shamim Seifzadeh | Set Designer |
| Conor O'Sullivan | Prosthetic Supervisor |
| Colin Nicolson | Production Sound Mixer |
| Colin Gregory | Boom Operator |
| Liam McCartney | Armorer |
| Andy Hunt | Prosthetics Sculptor |
| Katherine McCormack | Unit Publicist |
| Joel Behrens | Visual Effects Supervisor |
| Doug Moench | Thanks |
| Randy Torres | Sound Designer |
| Gil Kane | Thanks |
| Agis Pyrlis | Draughtsman |
| James Barham | First Assistant Editor |
| Victoria Keeling | Visual Effects Producer |
| David Maund | Key Grip |
| Hannah Storm Miles | Standby Painter |
| Toby Ford | First Assistant Director |
| Victoria Zalin | Production Supervisor |
| Jane Harwood | Assistant Art Director |
| James Nesbitt | Electrician |
| Eric Kimelton | Visual Effects Producer |
| Mitchell J. Glaser | Visual Effects Editor |
| Yoshi DeHerrera | Visual Effects Supervisor |
| Neil Floyd | Graphic Designer |
| Jakob Lundbye | VFX Artist |
| Montrice White | Assistant Editor |
| Rachel Aulton | Art Direction |
| Thayna McLaughlin | Second Assistant Sound |
| Keith Dawson | Special Effects Supervisor |
| Dan Garlick | Best Boy Grip |
| Seth Crosby | Electrician |
| Barry St. John | Co-Producer |
| Matt Gendron | Art Direction |
| Matthew Ellis | Production Secretary |
| Nina Jagersbacher | Assistant Costume Designer |
| Aisha Kascioglu | Assistant Costume Designer |
| Adam Byles | Second Assistant Director |
| Leon Seth | Assistant Location Manager |
| Howard Mackie | Thanks |
| Kasia Chojnowska | Tailor |
| Dominic Hailstone | Prosthetic Designer |
| Dan Slott | Thanks |
| Sacha Garrett | Casting Assistant |
| Garry Thomson | Electrician |
| Barrie Williams | Transportation Captain |
| Simon Thorpe | Dolly Grip |
| Dan Gamble | Second Assistant "A" Camera |
| Louise Young | Makeup Artist |
| Gary Lock | Property Master |
| Callum Collins | Electrician |
| Stuart Watson | Construction Manager |
| Holly Freeman | Costume Supervisor |
| Fred M. Ortiz | Set Dresser |
| Calle Tidbeck | Concept Artist |
| Colin Shulver | Prosthetic Designer |
| Thomas Kingett | Unit Manager |
| Tom Hyde | Electrician |
| Amelia Southgate | Production Coordinator |
| Louis Mackall | Visual Effects Supervisor |
| Mark Robson | Scenic Artist |
| Ellie Coverdale | Assistant Production Coordinator |
| Dwayne Turner | Storyboard Artist |
| George Tuska | Thanks |
| Daniel Vincze | Assistant Set Decoration |
| Cassandra Virdee | Draughtsman |
| Oliver Squire | Second Assistant "C" Camera |
| Ferenc Nothóf | Storyboard Artist |
| Grace Heath | Assistant Accountant |
| James Excell | Third Assistant Director |
| Dean Morrish | Second Assistant "B" Camera |
| Davina Greening | Seamstress |
| Beni Hardiman | Associate Producer |
| Harriet Hundertmark | Costume Coordinator |
| Martin Conway | Best Boy Electric |
| Jack Glascodine | Grip |
| Pete Steward | Standby Carpenter |
| Callum Watson | Standby Rigger |
| Eleri Coulten | Location Manager |
| Dan Connolly | Location Manager |
| Karin Kavanagh | Location Coordinator |
| Charlotte Hemsley | Assistant Location Manager |
| Ben White | Assistant Location Manager |
| Miguel Pariente | Production Accountant |
| Harmeek Singh Sandall | Payroll Accountant |
| Gareth Sprey | Draughtsman |
| Jonny Mellor | Scenic Artist |
| Humberto Ramos | Thanks |
| Cameron Taragel | Key Grip |
