 | Rebecca De Mornay als Natalie 'Mother' Koffin |
 | Jaime King als Beth Sohapi |
 | Frank Grillo als Daniel Sohapi |
 | Patrick John Flueger als Izaak 'Ike' Koffin |
 | Warren Kole als Addley Koffin |
 | Deborah Ann Woll als Lydia Koffin |
 | Matt O'Leary als Jonathan 'Johnny' Koffin |
 | Briana Evigan als Annette Langston |
 | Shawn Ashmore als George Barnum |
 | Kandyse McClure als Gina Jackson |
 | Lyriq Bent als Treshawn Jackson |
 | Lisa Marcos als Julie Ross |
 | Jessie Rusu als Melissa McGuire |
 | Tony Nappo als Dave Lowe |
 | Jason Wishnowski als Charlie Kaufman |
 | A.J. Cook als Vicky Rice |
 | Alexa PenaVega als Jenna Luther |
 | J. LaRose als Hospital Security Guard |
 | Jennifer Hupe als Young Nurse |
 | Mike O'Brien als Officer Skay |
 | Will Woytowich als Paramedic |
 | Omar Alex Khan als Surgeon |
 | Andrew Bryniarski als Quincy, Sanitation Worker #2 |
 | Joanne Rodriguez als Dry Cleaner (uncredited) |
| Darren Lynn Bousman | Director |
| Scott Milam | Screenplay |
| Brett Ratner | Producer |
| Richard Saperstein | Producer |
| Jay Stern | Producer |
| Brian Witten | Producer |
| Lindsey Hayes Kroeger | Casting |
| Bobby Johnston | Music |
| Leslie Kavanagh | Costume Design |
| Melissa R. Stubbs | Stunts |
| Allen Benjamin | Special Effects Coordinator |
| Kristen Sawatzky | Stunts |
| Charles Kaufman | Original Film Writer |
| Warren Leight | Original Film Writer |
| Scott Milam | Story |
| Lloyd Kaufman | Executive Producer |
| Shara Kay | Co-Producer |
| Charles Kaufman | Executive Producer |
| Andrew Golov | Executive Producer |
| Kyle Bornais | Executive Producer |
| Stephen Kessler | Executive Producer |
| Jessie Rusu | Executive Producer |
| Joseph White | Director of Photography |
| Réjean Labrie | Art Direction |
| Anthony Ianni | Production Design |
| Craig Sandells | Set Decoration |
| Doug Morrow | Makeup Department Head |
| Kerry Mendenhall | Hair Department Head |
| Damon Bishop | Special Effects Makeup Artist |
| Brenda Magalas | Makeup Artist |
| Megan Basaraba | Second Assistant Director |
| Richard O'Brien-Moran | First Assistant Director |
| Leon Johnson | Production Sound Mixer |
| Todd Beckett | Sound Re-Recording Mixer |
| Jeffrey A. Pitts | Sound Effects Editor |
| Mark L. Mangino | Supervising Sound Editor |
| Jon Campfens | Visual Effects Supervisor |
| Kelly Vandever | Sound Re-Recording Mixer |
| Peter Denomme | Visual Effects Producer |
| Daryl Dorge | Stunts |
| Bobby C. King | Stunt Coordinator |
| Craig Skene | Stunts |
| Sean Skene | Stunts |
| Dan Skene | Stunt Coordinator |
| Sarah Murphy-Dyson | Stunt Double |
| Richard Dean Thomas | Stunts |
| Jodi Terhoch | Stunts |
| Ari Robbins | Steadicam Operator |
| John Clarke | Gaffer |
| Paul Suderman | Camera Operator |
| Stephanie Gorin | Casting |
| Mathieu Reid | Color Timer |
| Jonathan McHugh | Music Supervisor |
| CindyMarie Small | Stand In |
| Tamara Mauthe | Production Coordinator |
| Donna Jenkyns | Art Department Coordinator |
| Reed Makayev | Assistant Director Trainee |
| Victoria Wood | Wigmaker |
| Hunter M. Via | Editor |
