 | Dustin Hoffman als Mr. Edward Magorium |
 | Natalie Portman als Molly Mahoney |
 | Jason Bateman als Henry Weston |
 | Zach Mills als Eric Applebaum |
 | Jonathan Potts als Dr. Sage |
 | Rebecca Northan als Ellie Applebaum |
 | David Rendall als Tim |
| Jade Cohen als Kangaroo Girl |
 | Marcia Bennett als Lora |
| Ted Ludzik als Bellini |
| Madalena Brancatella als Jessica |
 | Paula Boudreau als Brenda |
 | Mike Realba als Dave Wolf |
 | Steve Whitmire als Kermit the Frog (voice) |
| Liam Powley-Webster als Andy |
| Oliver Masuda als Jordan |
| Samantha Harvey als Cassie |
| Jesse Bostick als Derek |
| Isaac Durnford als Jason |
| Daniyah Ysrayl als Jimmy |
 | Dash Grundy als Ari |
 | Dylan Authors als Mark |
| Aidan Koper als Brett |
| Lin Lin Feng als Angie |
| He Wen als Larry |
| Gan Zhen als David |
| Quancetia Hamilton als Gia |
 | Kiele Sanchez als Mrs. Goodman |
 | David Collins als Tom |
 | Matt Baram als Eddie, the Dentist |
| Mathew Peart als Wyatt, Who Sells Hot Dogs |
| Michael Costa Parke als Jack, Who Thinks It's Magic (as Michael Costa-Parke) |
| Milo Gladstein als Milo, Who's Not Bad |
 | Kerry-Lee Finkle als Funeral Attendee (uncredited) |
 | Austin Macdonald als Boy in toy store (uncredited) |
 | Mani Nasry als Mani (uncredited) |
 | Christina Orjalo als Shop Girl (uncredited) |
| Jordan Dean Scott als Boy on Scooter (uncredited) |
| Daniella Tokic als Nurse (uncredited) |
 | Beatriz Yuste als Lora (uncredited) |
| Robin D. Cook | Casting |
| Colin Penman | Makeup Artist |
| Nikita Rae | Makeup Artist |
| Zach Helm | Director |
| Christopher Hargadon | Costume Design |
| Roman Osin | Director of Photography |
| Nathan Kahane | Executive Producer |
| Brandt Gordon | Art Direction |
| Clive Thomasson | Set Decoration |
| Barbara A. Hall | Producer |
| Amanda Mackey | Casting |
| James Garavente | Producer |
| Richard N. Gladstein | Producer |
| Joseph Drake | Executive Producer |
| Cathy Sandrich Gelfond | Casting |
| Valli O'Reilly | Makeup Artist |
| Sabrina Plisco | Editor |
| Alexandre Desplat | Original Music Composer |
| Thérèse DePrez | Production Design |
| Aaron Zigman | Original Music Composer |
| Zach Helm | Screenplay |
| Lyn Lucibello | Unit Production Manager |
| Jeff J.J. Authors | First Assistant Director |
| Jim Miller | Associate Producer |
| John Stoneham Jr. | Stunt Coordinator |
| Kelli Konop | Executive In Charge Of Production |
| Samantha Armstrong | Script Supervisor |
| Eric S. Potechin | Second Assistant Director |
| Brendan Bresnahan | Video Assist Operator |
| Marty Dejczak | Location Manager |
| Michael Galbraith | Gaffer |
| Michael Madden | Set Designer |
| Russell Moore | Set Designer |
| Collingwood Brown | Art Department Coordinator |
| Doug Graham | Set Dresser |
| David Jaquest | Set Dresser |
| Pauline Chung | Costume Supervisor |
| Roslyn Hanchard | Assistant Costume Designer |
| Glen Gauthier | Sound Mixer |
| Steve Switzer | Boom Operator |
| Moshe Saadon | Boom Operator |
| Bruce Stambler | Sound Designer |
| Michael Minkler | Sound Re-Recording Mixer |
| Bob Beemer | Sound Re-Recording Mixer |
| Harry Yoon | Additional Editing |
| Andrew Silver | Supervising Music Editor |
| Julie Pearce | Music Editor |
| Paul Aulicino | Sound Editor |
| John C. Stuver | Dialogue Editor |
| Becky Sullivan | Supervising ADR Editor |
| Marc Deschaine | Assistant Sound Editor |
| Brett Voss | Foley Supervisor |
| Seann Dougherty | Foley Editor |
| James Voss | Foley Editor |
| Barbara Harris | ADR Voice Casting |
| Raymond Gieringer | Visual Effects Supervisor |
| Robert Tenaglia | Transportation Coordinator |
| Aaron Zigman | Conductor |
| Cary Granat | Executive Producer |
| Steven Weisberg | Editor |
| Harry Yoon | Additional Editor |
