 | Robin Williams als Daniel Hillard / Mrs. Doubtfire |
 | Sally Field als Miranda Hillard |
 | Lisa Jakub als Lydia Hillard |
 | Matthew Lawrence als Chris Hillard |
 | Mara Wilson als Natalie Hillard |
 | Pierce Brosnan als Stu |
 | Robert Prosky als Mr. Lundy |
 | Anne Haney als Mrs. Sellner |
 | Harvey Fierstein als Frank |
 | Scott Capurro als Jack |
 | Polly Holliday als Gloria |
 | Sydney Walker als Bus Driver |
 | Joe Bellan als TV Boss |
 | Martin Mull als Justin Gregory |
 | Terence McGovern als ADR Director Lou |
 | Karen Kahn als Female Employee #1 |
| Eva Gholson als Female Employee #2 |
| James Cunningham als Male Employee |
 | Ralph Peduto als Cop |
 | Scott Beach als Judge |
| Juliette Marshall als Miranda's Attorney |
| Drew Letchworth als Daniel's Attorney |
 | Jessica Myerson als Miranda's Mother |
| Sharon Lockwood als Alice |
| James P. Cullen als Thug |
| Kenneth Loo als Staring Boy #1 |
| Jeff Loo als Staring Boy #2 |
| Betsy Monroe als Stunning Woman |
| Joseph Narducci als Delivery Boy |
| James Cranna als Ron |
| Dr. Toad als Bartender |
| Adele Proom als Lundy's Secretary |
 | Rick Overton als Maitre D' |
| Dan Spencer als Cook |
 | Paul Guilfoyle als Head Chef |
 | Molly McClure als Woman Housekeeper |
 | Andy Prosky als TV Director |
 | William Newman als Mr. Sprinkles |
| Christopher Pray als Puppeteer |
 | Geoff Bolt als Lundy's Waiter |
| Dick Bright als Stu's Waiter |
| Adam Bryant als Man in Men's Room |
| Tavia Cathcart als Tanya the Hostess |
| C. Beau Fitzsimons als Valet #1 |
| Jeff Moeller als Valet #2 |
| Benne Alder als Woman in Restroom |
 | Smadar Hanson als Waitress (uncredited) |
| Anne Fine | Novel |
| Marsha Garces Williams | Producer |
| Leslie Dixon | Screenplay |
| Matthew Rushton | Executive Producer |
| Chris Columbus | Director |
| Randi Mayem Singer | Screenplay |
| Robin Williams | Producer |
| Howard Shore | Original Music Composer |
| Joan Bradshaw | Producer |
| Jane Jenkins | Casting |
| W. Steven Graham | Art Direction |
| Donald McAlpine | Director of Photography |
| Garrett Lewis | Set Decoration |
| Janet Hirshenson | Casting |
| Angelo P. Graham | Production Design |
| Marit Allen | Costume Design |
| Mark Radcliffe | Producer |
| Raja Gosnell | Editor |
| Silvia Pompei | Animation |
| Paula DuPré Pesmen | Associate Producer |
| Vance Piper | First Assistant "A" Camera |
| Troy Brown | Stunt Coordinator |
| Pat Banta | Stunts |
| Leon Delaney | Stunts |
| Joan Bradshaw | Unit Production Manager |
| Geoffrey Hansen | First Assistant Director |
| Cherylanne Martin | Second Assistant Director |
| James J. Murakami | Assistant Art Director |
| Mark Woods | Leadman |
| Douglas Ryan | "A" Camera Operator |
| Kim Marks | "B" Camera Operator |
| John A. Small | Second Assistant "A" Camera |
| Patrick McArdle | First Assistant "B" Camera |
| Paul Sanchez | Second Assistant "B" Camera |
| Nelson Stoll | Sound Mixer |
| Fred Runner | Boom Operator |
| Carol DePasquale | Script Supervisor |
| Pamela S. Westmore | Makeup Artist |
| Ve Neill | Key Makeup Artist |
| Yolanda Toussieng | Key Hair Stylist |
| Virginia G. Hadfield | Hairstylist |
| Deirdre N. Williams | Costume Supervisor |
| Christine Peters | Costume Supervisor |
| Nancy Servin | Seamstress |
| Steven R. Mathis | Gaffer |
| Brett Laumann | Best Boy Electric |
| Frank Helbig | Electrician |
| Tom Cloutier | Electrician |
| Robin Alan Knight | Key Grip |
| Dave Childers | Best Boy Grip |
| Chuck Brown | Dolly Grip |
| Rod M. Janusch | Rigging Grip |
| John Zemansky | Property Master |
| Stephen Lee Davis | Second Second Assistant Director |
| Carol Bawer | Additional Second Assistant Director |
| Jacqueline A. Shea | Production Coordinator |
| Mary Duann | Assistant Production Coordinator |
| Ken Ryan | Production Accountant |
| Mayda Renizzi-Holt | Assistant Accountant |
| Kristen Ross | Art Department Coordinator |
| Steve Saklad | Set Designer |
| Steven Wolff | Set Designer |
| Robert C. Goldstein | Set Designer |
| Harold Fuhrman | Set Designer |
| Ellen Pasternack | Unit Publicist |
| Phil Bray | Still Photographer |
| Tim Silano | First Assistant Editor |
| Gary Rydstrom | Sound Designer |
| Gary Rydstrom | Sound Re-Recording Mixer |
| Tom Johnson | Sound Re-Recording Mixer |
| Gary Summers | Sound Re-Recording Mixer |
| Gloria S. Borders | Supervising Sound Editor |
| Robert Shoup | Sound Effects Editor |
| C.J. Appel | ADR Editor |
| Ewa Sztompke | Dialogue Editor |
| Sara Bolder | Dialogue Editor |
| Claire Sanfilippo | Dialogue Editor |
| Sandina Bailo-Lape | Foley Editor |
| Marian Wilde | Foley Editor |
| Clare C. Freeman | Assistant Sound Editor |
| Scott Guitteau | Assistant Sound Editor |
| Dianna Stirpe | Assistant Sound Editor |
| Kevin Rose-Williams | Assistant Sound Editor |
| Patti Tauscher | Assistant Sound Editor |
| Lora Hirschberg | Assistant Sound Designer |
| Dennie Thorpe | Foley Artist |
| Tom Barwick | Foley Artist |
| Christopher Boyes | Foley Recordist |
| Ellen Segal | Supervising Music Editor |
| Robin Katz | Music Editor |
| Dan Wallin | Scoring Mixer |
| Richard W. Clot | Construction Coordinator |
| John McLeod | Special Effects |
| Robert Neilson | Transportation Coordinator |
| Maylon Houston | Transportation Co-Captain |
| Michael Hirshenson | Casting Associate |
| Bonnie Hudson | Studio Teacher |
| Dennis McNeill | Color Timer |
| Gary Burritt | Negative Cutter |
| Bill Littlejohn | Animation |
| Barrie Nelson | Animation |
| Tom Ray | Animation |
| Tom Roth | Animation |
| Gary Archer | Prosthetics |
| David Draves | Stunts |
| Pat Banta | Stunt Double |
| Greg Cannom | Special Effects Makeup Artist |
| Kate O'Neill | Loader |
| Conrad Slater | Cableman |
| Bruce Devan | Location Manager |
| Debra A. Girard | Assistant Location Manager |
| James P. Cullen | Costume Supervisor |
| Kevin A. Thompson | Electrician |
| William Hampton | Electrician |
| Robert 'Boomer' McCann | Dolly Grip |
| Philip Ho | Grip |
| Michael Whitehurst | Grip |
| John Schoening | Rigging Grip |
| Cyndi McHale Margolis | Producer's Assistant |
| Rebecca Erwin Spencer | Producer's Assistant |
| Jay Roberts | Payroll Accountant |
| Don Watson | Swing |
| Emilio R. Aramendia | Swing |
| Eugene M. Texeira | Swing |
| Tara McKinley | Assistant Editor |
| Ron Fode | Projection |
| Lisa M. Devlin | Standby Painter |
| George Zimninsky | Greensman |
| James C. Taylor | Transportation Captain |
| Jonathan Doff | Video Assist Operator |
| Marty Brenneis | 24 Frame Playback |
| Schuyler Kent | Casting Assistant |
| Darin Rivetti | Set Production Assistant |
| Cindy M. Ichikawa | Set Production Assistant |
| Alexandra Fitzpatrick | Editorial Production Assistant |
| Randol Perelman-Taylor | Location Assistant |
| Cynthia LaPointe | Location Assistant |
| Susannah Greason | Location Assistant |
| Oscar Briones | Location Assistant |
| James J. Wilhelm | Craft Service |
| John Halko | Catering |
| Dirk Q. Long | Catering |
| Bill Powers | Catering |
| Curtis Hamlin | Catering |
| Steve Watson | Catering |
| Myra Rosenthal | Studio Teacher |
| Duane Gretsky | Animation |
| Eric Goldberg | Animation |
| Robert E. 'Bobby' Powell | Rigging Gaffer |
| Frank W. Tarantino | Special Effects |
| Leo Loverro | Special Effects |
| Geoff Heron | Special Effects |
| Chuck Jones | Animation |
