 | Nia Vardalos als Fotoula "Toula" Portokalos |
 | John Corbett als Ian Miller |
 | Lainie Kazan als Maria Portokalos |
 | Michael Constantine als Kostas "Gus" Portokalos |
 | Andrea Martin als Aunt Voula |
 | Joey Fatone als Angelo |
 | Louis Mandylor als Nick Portokalos |
 | Gia Carides als Nikki Portokalos |
 | Christina Eleusiniotis als Toula Portokalos - Age 6 |
| Marita Zouravlioff als Toula Portokalos - Age 12 |
 | Gerry Mendicino als Uncle Taki |
| Bess Meisler als Yiayia |
 | Jayne Eastwood als Mrs. White |
 | Fiona Reid als Harriet Miller |
 | Bruce Gray als Rodney Miller |
| Frank Falcone als Suitor |
 | Stavroula Logothettis als Athena |
 | Ian Gomez als Mike |
| Petra Wildgoose als Car Pool Friend |
| John Kalangis als Greek Teacher |
| Kaylee Vieira als Schoolgirl |
| Melissa Todd als Car Pool Friend |
| Sarah Osman als Athena Portokalos - Age 15 |
 | Gale Garnett als Aunt Lexy |
| Jeffrey Jur | Director of Photography |
| Alexander Janko | Original Music Composer |
| Tom Hanks | Producer |
| Joel Zwick | Director |
| Gary Goetzman | Producer |
| Rita Wilson | Producer |
| Chris Wilson | Original Music Composer |
| Nia Vardalos | Screenplay |
| Mia Goldman | Editor |
| Ann Brodie | Key Makeup Artist |
| Michael Clancy | Costume Design |
| Gregory P. Keen | Production Design |
| Jim Milio | Co-Executive Producer |
| Melissa Jo Peltier | Co-Executive Producer |
| Mark Hufnail | Co-Executive Producer |
| David Coatsworth | Co-Producer |
| Norm Waitt | Executive Producer |
| Paul Brooks | Executive Producer |
| Steven Shareshian | Executive Producer |
| Wayne Wightman | Assistant Art Director |
| Alan Doucette | Property Master |
| John Nelles | Dialogue Coach |
| Melissa Sherwood Hofmann | Sound Re-Recording Mixer |
| Geoffrey G. Rubay | Sound Re-Recording Mixer |
| Mike Stanwick | Color Timer |
| Mo Henry | Negative Cutter |
| James Wright | Dolby Consultant |
| Daniela Saioni | Script Supervisor |
| David Coatsworth | Unit Production Manager |
| David McAree | First Assistant Director |
| Grant Lucibello | Second Assistant Director |
| Heather Persons | Co-Editor |
| Deva Anderson | Music Supervisor |
| D.J. Carson | Assistant Production Manager |
| Andy Chmura | Camera Operator |
| Michael Galbraith | Gaffer |
| Rod Benjamin | Key Grip |
| Paul R.J. Elliot | Key Hair Stylist |
| Kei Ng | Art Direction |
| Enrico Campana | Set Decoration |
| Paul Timothy Carden | Supervising Sound Editor |
| Kimberly Harris | ADR Supervisor |
| Alex Gibson | Music Editor |
| Steve Rundell | Digital Effects Supervisor |
| Marsha Robertson | Unit Publicist |
| Effy Papadopoulos | Third Assistant Director |
| Don Retzer | Transportation Coordinator |
| John Colavecchia | First Assistant Camera |
| Keith Murphy | Steadicam Operator |
| Cylvan Desrouleaux | Second Assistant Camera |
| Sophie Giraud | Still Photographer |
| Dorota Zajac | Makeup Artist |
| Burton J. LeBlanc | Makeup Artist |
| Beatrice Salazar | Hairstylist |
| Sandra Reynolds | Hairstylist |
| Jay Du Boisson | Assistant Costume Designer |
| Gary Harmer | Leadman |
| Gordon Lebredt | Graphic Designer |
| Rossana DeCampo | Scenic Artist |
| Mark Thomson | Construction Coordinator |
| Tom Mather | Sound Mixer |
| Thomas Hayek | Boom Operator |
| John Kenyon | Location Manager |
| Armen Ksajikian | Musician |
