 | Will Ferrell als Ted (Man with the Yellow Hat) (voice) |
 | Drew Barrymore als Maggie (voice) |
 | David Cross als Junior (voice) |
 | Eugene Levy als Clovis (voice) |
 | Joan Plowright als Ms. Plushbottom (voice) |
 | Dick Van Dyke als Mr. Bloomsberry (voice) |
 | Frank Welker als George (voice) |
 | Ed O'Ross als Ivan (voice) |
 | Michael Chinyamurindi als Edu (voice) |
 | Michael Sorich als "Seen It" Cab Driver (voice) |
 | Billy West als Manager (voice) |
 | Jeff Bennett als Salesman (voice) |
 | Kath Soucie als Animal Control Receptionist (voice) |
 | Clint Howard als Balloon Man (voice) |
 | Shane Baumel als Kid (voice) |
| Timyra-Joi Beatty als Kid (voice) |
| Christopher Chen als Kid (voice) |
 | Michaela Jill Murphy als Kid (voice) |
 | Alexander Gould als Kid (voice) |
 | Terrence Hardy Jr. als Kid (voice) |
 | Hailey Noelle Johnson als Kid (voice) |
 | Kelsey Lansdowne als Kid (voice) |
 | Ariel Winter als Kid (voice) |
 | Kimberly Brooks als Additional Voices (voice) |
 | Wendy Cutler als Additional Voices (voice) |
| Joey D'Auria als Additional Voices (voice) |
 | Richard Epcar als Additional Voices (voice) |
 | Treva Etienne als Additional Voices (voice) |
 | Eddie Frierson als Additional Voices (voice) |
 | Donald Fullilove als Additional Voices (voice) |
 | Philip Maurice Hayes als Additional Voices (voice) |
 | Bridget Hoffman als Additional Voices (voice) |
 | Rif Hutton als Additional Voices (voice) |
 | Steve Kehela als Additional Voices (voice) |
| Grier King als Additional Voices (voice) |
 | Donna Lynn Leavy als Additional Voices (voice) |
| Nadia Lewis als Additional Voice (voice) |
 | John Mariano als Additional Voices (voice) |
 | Caitlin McKenna als Additional Voices (voice) |
| Kerry Michele als Additional Voice (voice) |
 | Juan Pope als Additional Voices (voice) |
 | Jonny Solomon als Additional Voices (voice) |
 | Mandy Fabian als Additional Voices (voice) |
 | Fred Tatasciore als Additional Voices (voice) |
| Julie Rogers | Editor |
| Yarrow Cheney | Production Design |
| Ron Howard | Producer |
| Jon Shapiro | Producer |
| Ken Tsumura | Executive Producer |
| Mary Alice Drumm | Line Producer |
| David Bernardi | Executive Producer |
| David Kirschner | Producer |
| Bonne Radford | Executive Producer |
| Jim Whitaker | Executive Producer |
| Heitor Pereira | Original Music Composer |
| Matthew O'Callaghan | Director |
| Ken Kaufman | Screenplay |
| Mike Werb | Story |
| Ken Kaufman | Story |
| Margret Rey | Book |
| Johan Klingler | Layout |
| Trevor Tamboline | Animation |
| George Villaflor | Layout |
| James Baxter | Animation Supervisor |
| Andy Schuhler | Animation |
| Luc Desmarchelier | Visual Development |
| John Bermudes | Visual Effects Supervisor |
| Craig R. Maras | Animation |
| James Baker | Animation |
| Eric Koenig | Animation |
| Cilbur Rocha | Animation |
| Blair Kitchen | Animation |
| Matt Williames | Animation |
| Harald Kraut | Layout |
| Matthew Maners | Animation |
| Claire Williams | Layout |
| Edward P. Pedersen | Production Manager |
| Kezia Ma | Animation |
| Juan 'Jo' Luna | Layout |
| Jeff Johnson | Lead Animator |
| Stevan Wahl | Lead Animator |
| Shane Prigmore | Character Designer |
| David 'Joey' Mildenberger | Visual Effects Supervisor |
| Darlie Brewster | Lead Animator |
| Frans Vischer | Lead Animator |
| Jeff Johnson | Character Designer |
| Anthony DeRosa | Lead Animator |
| John Pomeroy | Lead Animator |
| David Lee | Prop Designer |
| Billy George | Layout |
| H.A. Rey | Book |
| Barry Caldwell | Storyboard Artist |
| Bill Thyen | Storyboard Artist |
| Caroline Cruikshank | Storyboard Artist |
| Frans Vischer | Storyboard Artist |
| Kurt Anderson | Storyboard Artist |
| Peter Paul Bautista | Storyboard Artist |
| Alan J. Hagge | Systems Administrators & Support |
| Jack Johnson | Songs |
