 | Owen Wilson als Jack Dwyer |
 | Lake Bell als Annie Dwyer |
 | Pierce Brosnan als Hammond |
 | Sterling Jerins als Lucy Dwyer |
 | Claire Geare als Beeze Dwyer |
 | Spencer Garrett als Recruiter |
 | Sahajak Boonthanakit als Kenny Rogers |
 | Tanapol Chuksrida als Krit |
 | Nophand Boonyai als Concierge |
 | Byron Gibson als Hotel Guest #1 |
 | Matthew Timothy Olynyk als Hotel Guest #2 |
 | Stacy Chbosky als Mother / Woman Next Door |
 | Suphornaphat Annie Jenselius als Travel Agent |
 | Hiroyuki Kobayashi als Japanese Businessman |
| Thanawut Ketsaro als Samnang |
 | David Prak als Khmer (voice) (uncredited) |
| Jimmy Chhiu als Voice actor (uncredited) |
| Mia Sun als Voice actor (uncredited) |
 | Dollar Tan als Voice actor (uncredited) |
| Sam B. Lorn als Voice actor (uncredited) |
 | Bonnie Zellerbach als Sandra (uncredited) |
 | Ego Mikitas als Actor / Host (uncredited) |
 | Jim Lau als Prime Minister (uncredited) |
| Charlie Sungkawess als Late Night Reveler |
| Chatchawan Kamonsakpitak als Prak |
| John Erick Dowdle | Director |
| Drew Dowdle | Producer |
| Michel Litvak | Producer |
| David Lancaster | Producer |
| Chris Lowenstein | Co-Producer |
| Léo Hinstin | Director of Photography |
| Marco Beltrami | Original Music Composer |
| Buck Sanders | Original Music Composer |
| John Erick Dowdle | Writer |
| Drew Dowdle | Writer |
| Stephanie Wilcox | Co-Producer |
| Steve Alexander | Executive Producer |
| Andrew Pfeffer | Executive Producer |
| Gary Michael Walters | Executive Producer |
| Elliot Greenberg | Editor |
| Eyde Belasco | Casting |
| Thitiya Thongbai | Casting |
| Arvinder Greywal | Production Design |
| Boontawee 'Tor' Taweepasas | Art Direction |
| Annie Bloom | Costume Design |
| Sunisa 'Faa' Siribothi | Art Department Coordinator |
| Woraphol 'Pao' Dhanashoti | Construction Coordinator |
| Terence J. Cox | Special Effects Supervisor |
| Sam Cornwell | Visual Effects Coordinator |
| Isaac Lipstadt | Visual Effects Coordinator |
| Lauren F. Ellis | Visual Effects Producer |
| Carla Schwam | Visual Effects Producer |
| Michael T. Kennedy | Visual Effects Supervisor |
| Richie Moore | Camera Operator |
| Roland Neveu | Still Photographer |
| Tiptalee Chanaputtakun | Hairstylist |
| Geraldine Jones | Hairstylist |
| Watana Garum | Makeup Artist |
| Daniel Parker | Makeup Artist |
| Tara Blume | Foley |
| Gary A. Hecker | Foley |
| Gary Marullo | Foley |
| Karen Vassar Triest | Sound Designer |
| Chuck Peterson | Sound Effects Editor |
| Joe Barnett | Sound Re-Recording Mixer |
| Mark Paterson | Sound Re-Recording Mixer |
| Kelly Oxford | Supervising Sound Editor |
| Damian Mavis | Stunts |
| Warwick Sadler | Stunts |
| Genevieve Aitken | Stunt Double |
| Chatree Jumpimai | Ager/Dyer |
| Thitipang Pungsung | Ager/Dyer |
| Sirisuk Chopthamdi | Seamstress |
| Tornchanok Wongrasri | Seamstress |
| Waraporn Kheawnanjai | Wardrobe Supervisor |
| Chetsada Netroong | Aerial Coordinator |
| Siriporn Peerethamrongkul | Production Accountant |
| George Sweney | Production Accountant |
| Pongphan Jormsak | Production Coordinator |
| Nuchanart Chareonsontichai | Production Secretary |
| Navarutt Roongaroon | Script Supervisor |
| Ruchira Huachaipet | Travel Coordinator |
| Kevin Godkin | Armorer |
| Anuchit Sae Ear | Construction Foreman |
| Songkran Toekulvat | Construction Foreman |
| Worapol Thanachodi | Construction Manager |
| Chathip Henprasert | Graphic Designer |
| Sorayuk Mookleemas | Property Master |
| Eric Yamamoto | Storyboard Artist |
| Prawee Niemsakul | Storyboard Artist |
| Christopher Barrick | ADR Mixer |
| Michael Miller | ADR Mixer |
| Chris Navarro | ADR Mixer |
| David Weisberg | ADR Mixer |
| Annop Jaikaew | Boom Operator |
| Yuthsak Janmom | Cableman |
| David Stanke | First Assistant Sound Editor |
| Tara Blume | Foley Artist |
| Gary Marullo | Foley Artist |
| Darren Sunny Warkentin | Foley Editor |
| Ryan Wassil | Foley Editor |
| Nerses Gezalyan | Foley Mixer |
| David Madigan | Production Sound Mixer |
| Kathie Talbot | Sound Designer |
| Dan Hegeman | Sound Effects Editor |
| Stephen P. Robinson | Sound Effects Editor |
| Jeff Sawyer | Sound Effects Editor |
| Jein Choi | Animation |
| Dongyeon Jeon | Animation |
| Mathias Frodin | Digital Compositor |
| Hyunwook Kim | Lead Animator |
| Hyunseong Yu | Lead Animator |
| Elias Gonzalez | Matte Painter |
| Aaron Becker | Title Designer |
| Samuel Cornwell | Visual Effects Coordinator |
| Katrina Kim | Visual Effects Coordinator |
| Pramoon Anantawut | Assistant Gaffer |
| Kriangkri Intachai | Best Boy Grip |
| Archawin Saengritt | Camera Operator |
| Somsak Srisawat | Camera Operator |
| Wanchai Konchom | Dolly Grip |
| Preeda Bouryai | Electrician |
| Saichol Sanpak | Electrician |
| Pitak Sopo | Electrician |
| Mongkol Thappakwan | Electrician |
| Tawatchai Thipsombut | Electrician |
| Stanislav Aistov | Epk Camera Operator |
| Wirot Sittiwech | Gaffer |
| Nut Wilaikanund | Generator Operator |
| Tessakarn Laopakdee | Key Grip |
| Herbert Dwight Raymond IV | Assistant Editor |
| Pachara Tanjariyanond | Assistant Editor |
| Kenneth Robinson | Colorist |
| Eric Canto | Digital Intermediate |
| Jason Modica | Digital Intermediate |
| Daniel Hawley | Digital Intermediate Producer |
| Heidi Tebo | Digital Intermediate Producer |
| John Ott | First Assistant Editor |
| W.D. Hogan | Storyboard Artist |
