 | Morgan Freeman als Charlie |
 | Renée Zellweger als Betty |
 | Chris Rock als Wesley |
 | Greg Kinnear als Dr. David Ravell |
 | Aaron Eckhart als Del |
 | Tia Texada als Rosa |
 | Crispin Glover als Roy |
 | Pruitt Taylor Vince als Ballard |
 | Allison Janney als Lyla |
 | Kathleen Wilhoite als Sue Ann |
 | Elizabeth Mitchell als Chloe |
 | Susan Barnes als Darlene |
 | Harriet Sansom Harris als Ellen |
 | Sung-Hi Lee als Jasmine |
 | Laird Macintosh als Dr. Lonnie Walsh |
 | Steven Gilborn als Blake |
 | Jenny Gago als Mercedes |
 | Sheila Kelley als Joyce |
 | Matthew Cowles als Merle |
 | Wayne Tippit als Doctor |
 | George D. Wallace als Grandfather |
 | Lesley Woods als Grandmother |
 | Cynthia Martells als Chief Nurse |
 | Alfonso Freeman als ER Doctor |
 | Kevin Rahm als Friend #1 |
 | Steven Culp als Friend #2 |
 | Deborah May als Gloria Walsh |
 | Max Murphy als Studio Guard |
| Tina Smith als Waitress |
 | T.J. Kennedy als Cook |
 | Irene Olga López als Rosa's Mother |
 | Steve Franken als Administrator |
| Kelwin Hagen als Deputy |
| Josh Dotson als Parking Valet |
 | Dona Hardy als Woman Patient |
| Paul Threlkeld als Grip |
| José Vásquez als Gang Member |
| Jack Jacobson als Stagehand |
 | Elaine Corral Kendall als Anchor |
 | Greg Bronson als Diner Patron (uncredited) |
| Michelle Carmen Gomez als Woman at Bar (uncredited) |
| Toby Linz als Sue Ann's Son (uncredited) |
 | Hillary Straney als Woman in Hotel (uncredited) |
 | Jenny Wade als Diner Waitress (uncredited) |
| Neil LaBute | Director |
| John C. Richards | Screenplay |
| Steve Golin | Producer |
| Rolfe Kent | Original Music Composer |
| Jean-Yves Escoffier | Director of Photography |
| Joel Plotch | Editor |
| James Flamberg | Screenplay |
| Moritz Borman | Executive Producer |
| W. Mark McNair | Associate Producer |
| Gail Mutrux | Producer |
| Stephen Pevner | Executive Producer |
| Albert M. Shapiro | Associate Producer |
| Chris Sievernich | Executive Producer |
| Philip Steuer | Executive Producer |
| Steven Weisberg | Editor |
| Heidi Levitt | Casting |
| Monika Mikkelsen | Casting |
| Charles William Breen | Production Design |
| Gary Diamond | Art Direction |
| Jeffrey Kushon | Set Decoration |
| Lynette Meyer | Costume Design |
| Tim Clawson | Unit Production Manager |
| Fabio Massimo Dell'Orco | Production Manager |
| Steven Kaminsky | Post Production Supervisor |
| Henry Alberti | Set Designer |
| Stan Tropp | Set Designer |
| Leah Buono | Casting Assistant |
| Brett Greenstein | Casting Assistant |
| Enrico Latella | Location Manager |
| John Panzarella | Location Manager |
| Frankie Pine | Music Supervisor |
| Nick South | Editor |
| Alexa Alden | Script Supervisor |
| Karen Ruth Getchell | Production Coordinator |
| Albert M. Shapiro | First Assistant Director |
| Susan J. Hellmann | Second Assistant Director |
| Jack Gill | Stunts |
| Kevin Scott | Stunts |
| Scott Workman | Stunts |
| Michael A. Chavez | Camera Operator |
| Todd McMullen | First Assistant Camera |
| Michael Cassidy | Second Assistant Camera |
| Robin Bursey | Camera Loader |
| Nour Dardari | Production Accountant |
| Phil Hardage | Second Second Assistant Director |
| Larry J. White II | Leadman |
| Tracy Farrington | Property Master |
| Melissa Mollo | Graphic Designer |
| Bruce Birmelin | Still Photographer |
| Felipe Borrero | Sound Mixer |
| Thomas Cunliffe | Boom Operator |
| Larz Anderson | Special Effects Coordinator |
| Shari Gray | Costume Supervisor |
| Mynka Draper | Costumer |
| Jennifer Dozier | Costumer |
| Desne J. Holland | Key Makeup Artist |
| Michael Hancock | Makeup Artist |
| Sharon Ilson | Makeup Artist |
| Lisa Deveaux | Makeup Artist |
| Charlie Brewer | Stunt Coordinator |
| Andre Blaise | Key Hair Stylist |
| Deena Adair | Hairstylist |
| Colleen Callaghan | Hairstylist |
| Scott Julion | Hairstylist |
| Michael Bauman | Gaffer |
| Jorge H. Guzman | Key Grip |
| Paul Threlkeld | Dolly Grip |
| Martin Bosworth | Rigging Gaffer |
| Richard Puga | Standby Painter |
| Antonio Molina | Transportation Coordinator |
| Eric L. Roberts | Video Assist Operator |
| Randy Trager | Assistant Editor |
| Wade Bartlett | Assistant Editor |
| Richard E. Yawn | Supervising Sound Editor |
| Becky Sullivan | Supervising ADR Editor |
| Lance Brown | Sound Designer |
| Bob Beher | Foley Supervisor |
| Steve Mann | Sound Editor |
| Steve Nelson | Sound Editor |
| Robert Troy | Sound Editor |
| Donald L. Warner Jr. | Sound Editor |
| Bernard Weiser | Sound Editor |
| Aaron D. Weisblatt | Sound Editor |
| Tim Tuchrello | Assistant Sound Editor |
| Shawn Egan | Assistant Sound Editor |
| Eric Thompson | ADR Mixer |
| Eric Thompson | Foley Mixer |
| Shawn Kennelly | ADR Mixer |
| Shawn Kennelly | Foley Mixer |
| Joan Rowe | Foley Artist |
| Sean Rowe | Foley Artist |
| Thor Benitez | ADR Recordist |
| Chris Staszak | ADR Recordist |
| Chris David | Sound Re-Recording Mixer |
| Lance Brown | Sound Re-Recording Mixer |
| Eddie Bydalek | Sound Recordist |
| Nick South | Music Editor |
| Tony Blondal | Orchestrator |
| William T. Stromberg | Conductor |
| Barbara Harris | ADR Voice Casting |
| Philip Steuer | Second Unit Director |
| Dean Lyras | Second Unit Director of Photography |
| Mo Henry | Negative Cutter |
| Dan Valliere | Color Timer |
| John C. Richards | Story |
| Tim Gilbert | Stunts |
| Simone Boisseree | Stunts |
| David A. Armstrong | First Assistant Camera |
