 | Garrett Hedlund als Dean Moriarty / Neal Cassady |
 | Sam Riley als Sal Paradise / Jack Kerouac |
 | Kristen Stewart als Marylou / LuAnne Henderson |
 | Amy Adams als Jane / Joan Vollmer |
 | Tom Sturridge als Carlo Marx / Allen Ginsberg |
 | Kirsten Dunst als Camille / Carolyn Cassady |
 | Viggo Mortensen als Old Bull Lee / William S. Burroughs |
 | Danny Morgan als Ed Dunkle / Al Hinkle |
 | Alice Braga als Terry / Bea Franco |
 | Elisabeth Moss als Galatea Dunkel / Helen Hinkle |
 | Terrence Howard als Walter |
 | Sarah Allen als Vicki |
 | Kim Bubbs als Laura |
 | Eric Davis als Paul |
 | Giselle Itié als Tonia |
 | Steve Buscemi als Tall thin salesman |
 | Giovanna Zacarías als Puta Loca Roja |
 | Coati Mundi als Slim Gaillard |
 | John Burnside als Ghostly Hobo (uncredited) |
 | Omoze Idehenre als Black Woman |
 | Kaniehtiio Horn als Rita Bettancourt |
 | Joe Chrest als Virginia Cop |
 | Rocky Marquette als Alfred |
 | Jenessa Grant als Farmer’s Daughter (uncredited) |
 | Kyle Gatehouse als Migrant Worker |
 | Daniel Kash als Henry Glass |
| Walter Salles | Director |
| Jose Rivera | Screenplay |
| Francis Ford Coppola | Executive Producer |
| Nathanaël Karmitz | Producer |
| Charles Gillibert | Producer |
| Jack Kerouac | Novel |
| Gustavo Santaolalla | Original Music Composer |
| Éric Gautier | Director of Photography |
| Danny Glicker | Costume Design |
| François Gédigier | Editor |
| Carlos Conti | Production Design |
| Pablo Ramos | Script Supervisor |
| Patrick Batteux | Executive Producer |
| Arpad Busson | Executive Producer |
| Roman Coppola | Producer |
| Leticia Cristi | Executive Producer |
| Alex Killian | Producer |
| Lyse Lafontaine | Executive Producer |
| Jerry Leider | Executive Producer |
| Matías Mosteirín | Executive Producer |
| Mauricio Andrade Ramos | Producer |
| John H. Williams | Executive Producer |
| Tessa Ross | Executive Producer |
| Rebecca Yeldham | Producer |
| Michael Zakin | Executive Producer |
| Richard Hicks | Casting |
| David Rubin | Casting |
| Anne Moralis | Wigmaker |
| Tony Ward | Hairstylist |
| Stacy Kelly | Makeup Artist |
| John Caglione Jr. | Special Effects Makeup Artist |
| Marisa Amenta | Makeup Artist |
| Susan Alegria | Art Direction |
| Érika Ávila | Set Decoration |
| Martin Gendron | Art Direction |
| María Paz Gonzáles | Set Decoration |
| Monroe Kelly | Art Direction |
| Claude Leclair | Set Decoration |
| Gabriela Matus | Set Decoration |
| Maria Nay | Set Decoration |
| Graciela Oderigo | Art Direction |
| Hania Robledo | Art Direction |
| Leonard R. Spears | Set Decoration |
| Vincent Aird | Set Decoration |
| Pascal Chauvin | Foley Artist |
| Franck Tassel | Foley Artist |
| Brian Bowles | Dialogue Editor |
| Jean-Paul Hurier | Sound Re-Recording Mixer |
