 | Kingsley Ben-Adir als Malcolm X |
 | Eli Goree als Cassius Clay |
 | Aldis Hodge als Jim Brown |
 | Leslie Odom Jr. als Sam Cooke |
 | Joaquina Kalukango als Betty X |
 | Nicolette Robinson als Barbara Cooke |
 | Michael Imperioli als Angelo Dundee |
 | Lawrence Gilliard Jr. als Bundini Brown |
 | Christian Magby als Jamaal |
 | Jeremy Pope als Jackie Wilson |
 | Christopher Gorham als Johnny Carson |
 | Beau Bridges als Mr. Carlton |
 | Lance Reddick als Brother Kareem |
 | Derek Roberts als Jerome X |
 | Emily Bridges als Emily Carlton |
 | Amondre D. Jackson als L.C. Cooke |
| Jerome A. Wilson als Elijah Muhammad |
 | Hunter Burke als Jess Rand |
| Robert Stevens Wayne als Jules Podell |
 | Randall Newsome als Myron Cohen |
 | Matt Fowler als Ronnie |
| Chris Game als Ferdie Pacheco |
 | Alan Wells als Ed McMahon |
 | Dustin Lewis als Miami Announcer |
 | John Curran als Wembley Announcer #1 |
 | Mark Allan Stewart als Wembley Announcer #2 |
| Amar Khalil als Bobby |
| Ian Alexander Desdune II als Michael |
 | Jeremy Anderson als Lamont 3X |
| Pierce Lackey als Reporter 1 |
 | Dave Pileggi als Reporter 2 |
 | Ashley LeConte Campbell als Karen |
| Kimberly B Brown als Geraldine Liston |
| Nola Epps als Attallah Shabazz |
| Kipori Woods als Cliff White |
| Joshua Nylan Tanner als Boston Ballroom Announcer |
| Sean Monaghan als Henry 'The Hammer' Cooper |
 | Aaron D. Alexander als Sonny Liston |
 | Jason Ament als Miami Referee |
| Nathan Siebring als Wembley Referee |
 | Kevin Reid als Cameraman |
| Cody Johnson als Tristen |
| Regina King | Director |
| Kemp Powers | Screenplay |
| Jessica Wu | Producer |
| Keith Calder | Producer |
| Jody Klein | Producer |
| Regina King | Executive Producer |
| Kemp Powers | Executive Producer |
| Paul O. Davis | Executive Producer |
| Tami Reiker | Director of Photography |
| Tariq Anwar | Editor |
| Kimberly Hardin | Casting |
| Barry Robison | Production Design |
| Terence Blanchard | Original Music Composer |
| Mark Zuelzke | Art Direction |
| Tamar Barnoon | Set Decoration |
| Janessa Hitsman | Set Decoration |
| Francine Jamison-Tanchuck | Costume Design |
| Andy Hay | Supervising Sound Editor |
| Paul Ledford | Production Sound Mixer |
| Duncan McRae | Sound Re-Recording Mixer |
| Bryan Parker | Sound Designer |
| Xiao'ou Olivia Zhang | Sound Designer |
| Kemp Powers | Theatre Play |
| Chris Harding | Executive Producer |
| John H. Han | Visual Effects Supervisor |
| Randall Poster | Music Supervisor |
| Paul O. Davis | Unit Production Manager |
| Mark Anthony Little | First Assistant Director |
| Kevin O'Neil | Second Assistant Director |
| Larnell Stovall | Stunt Coordinator |
| Tim Bell | Stunt Coordinator |
| Joseph Singletary | Stunt Double |
| Vlad Rimburg | Stunts |
| Khalid Ghajji | Stunts |
| David Anthony Buglione | Stunts |
| Colette S. Knight | Production Supervisor |
| Chad Chamberlain | Steadicam Operator |
| Chad Chamberlain | "A" Camera Operator |
| Austin Alward | "B" Camera Operator |
| Sarah Brandes | First Assistant "A" Camera |
| Sienna Pinderhughes | Second Assistant "A" Camera |
| Haley Turk | Second Assistant "B" Camera |
| Zachary Blosser | First Assistant "B" Camera |
| Tyler Blackwell | Digital Imaging Technician |
| Patti Perret | Still Photographer |
| Markus Wittman | Leadman |
| Chelsey Staggs | Set Decorating Coordinator |
| Kyle Courter | Set Designer |
| Stephanie Parker | Set Designer |
| Bradford Johnson | Set Decoration Buyer |
| Jossie Rodriguez | Set Decoration Buyer |
| Edward J. Borasch Jr | Property Master |
| Drew Guajardo | Assistant Property Master |
| Dana Robertson | Art Department Coordinator |
| Paulo DeFreitas Jr. | Storyboard Artist |
| Mildred Brignoni | Assistant Costume Designer |
| Wendy Talley | Costume Supervisor |
| Juliana Hoffpauir | Key Costumer |
| Malikka Coston | Set Costumer |
| Kasey C. Bazil | Set Costumer |
| Olivia Vestina Torres | Costumer |
| Kazli Sullivan | Tailor |
| Karen Clark | Seamstress |
| Scott Wheeler | Makeup Department Head |
| Nakoya Yancey | Hair Department Head |
| Wayne Jolla Jr. | Key Hair Stylist |
| Sabana Majeed | Additional Hairstylist |
| Manda Haykus | Production Secretary |
| Cam Owen | Production Coordinator |
| Nancy Breaux | Script Supervisor |
| Maggie Means | Production Accountant |
| Steve Mattus | Payroll Accountant |
| Donovan Thibodeaux | Boom Operator |
| Allen Parks | Gaffer |
| Nick Kramer | Best Boy Electric |
| Chris Ekstrom | Key Grip |
| Andre Green | Rigging Gaffer |
| Tracy Kilpatrick | Location Casting |
| Christian Bustamante | Casting Associate |
| Yolanda D. Hunt | Casting Associate |
| Brent Caballero | Extras Casting |
| Rikki Hegwood | Extras Casting Coordinator |
| Tre Cotten | Dialect Coach |
| Jeffrey Gowing | Transportation Coordinator |
| Lionel C. Johnson | Transportation Captain |
| Win Riley | Location Manager |
| Erik van Haaren | Construction Coordinator |
| David Fields | Assistant Location Manager |
| John Collins | Assistant Location Manager |
| Edward Joubert | Special Effects Coordinator |
| Kate Ransome Wilcox | Second Second Assistant Director |
| Chris Ubick | Property Master |
| Amanda Beggs | Production Sound Mixer |
| Rich King | Extras Casting |
| Neal Prosansky | Location Manager |
| Dale Robinette | Still Photographer |
| Bo Shurling | Unit Publicist |
| Naomi Sunrise Filoramo | Assistant Editor |
| Michael Baird | Dialogue Editor |
| Paul Timothy Carden | Dialogue Editor |
| Pernell L. Salinas | First Assistant Sound Editor |
| Jack Cucci | Foley Mixer |
| John T. Cucci | Foley Artist |
| Dan O'Connell | Foley Artist |
| Tavish Grade | Foley Mixer |
| Andy Hay | Sound Re-Recording Mixer |
| Joshua Adeniji | Foley Editor |
| John H. Han | Visual Effects Producer |
| Teddy Blanks | Title Designer |
| Ian Vertovec | Digital Intermediate Colorist |
| Matt Blackshear | Digital Intermediate Editor |
| Andrew Brueck | Digital Intermediate Editor |
| Cielle Kiewit | Digital Intermediate Producer |
| Louie Schultz | Music Editor |
| Terence Blanchard | Orchestrator |
| Greg Hayes | Scoring Mixer |
| Gary Archer | Prosthetics |
| Michael W. Hoban | Rigging Grip |
| Andres Kluge | CG Supervisor |
| Marko Post | Visual Effects Producer |
| Sandra Leushina | Visual Effects Producer |
| Martin Turu | Compositing Lead |
