 | Tom Holland als Ian Lightfoot (voice) |
 | Chris Pratt als Barley Lightfoot (voice) |
 | Julia Louis-Dreyfus als Laurel Lightfoot (voice) |
 | Octavia Spencer als The Manticore (voice) |
 | Mel Rodriguez als Officer Colt Bronco (voice) |
 | Kyle Bornheimer als Wilden Lightfoot (voice) |
 | Lena Waithe als Officer Spector (voice) |
 | Ali Wong als Officer Gore (voice) |
 | Grey DeLisle als Dewdrop (voice) |
 | Tracey Ullman als Grecklin (voice) |
 | Wilmer Valderrama als Gaxton (voice) |
 | John Ratzenberger als Construction Worker Fennwick (voice) |
 | George Psarras als Officer Avel (voice) |
| Kori Rae | Producer |
| Mychael Danna | Original Music Composer |
| Pete Docter | Executive Producer |
| Jeff Danna | Original Music Composer |
| Shelley Roden | Foley Artist |
| Noah Klocek | Production Design |
| Nia Hansen | Sound Designer |
| Juan Peralta | Sound Re-Recording Mixer |
| Adam Sharpe | ADR Mixer |
| Dovi Anderson | Animation |
| Samson Neslund | Sound Effects Editor |
| Simon Baek | Set Designer |
| James W. Brown | Animation |
| Catherine Apple | Editor |
| Bert Berry | Art Direction |
| Christopher Flick | Foley Supervisor |
| Shannon Mills | Supervising Sound Editor |
| Adam Habib | Director of Photography |
| Sharon Calahan | Director of Photography |
| Dan Scanlon | Screenplay |
| Dan Scanlon | Director |
| Keith Bunin | Screenplay |
| Jason Headley | Screenplay |
| Becky Neiman | Associate Producer |
| Kelsey Mann | Story Supervisor |
| Sanjay Bakshi | Supervising Technical Director |
| Michael Stocker | Animation Supervisor |
| Rob Duquette Thompson | Animation Supervisor |
| Jonathan Pytko | Lighting Supervisor |
| Jordan Rempel | Lighting Supervisor |
| Jessie Thiele | Post Production Supervisor |
| Natalie Lyon | Casting |
| Kevin Reher | Casting |
| Kate Hansen-Birnbaum | Casting Associate |
| Jason Brodkey | First Assistant Editor |
| Mark Dinicola | Colorist |
| Shannon Mills | Sound Designer |
| Michael Semanick | Sound Re-Recording Mixer |
| Chris Gridley | ADR Supervisor |
| Kimberly Patrick | Sound Effects Editor |
| Josh Gold | Sound Effects Editor |
| David C. Hughes | Sound Effects Editor |
| Steve Orlando | Foley Editor |
| John Roesch | Foley Artist |
| Scott Curtis | Foley Mixer |
| Erich Stratmann | Music Editor |
| Seong-Young Kim | Layout |
| Jesus Martinez | VFX Production Coordinator |
| Rosana Sullivan | Storyboard Artist |
| Kenny Pickett | Sound |
