 | Simon Pegg als Graeme Willy |
 | Nick Frost als Clive Gollings |
 | Seth Rogen als Paul (voice) |
 | Jason Bateman als Special Agent Lorenzo Zoil |
 | Kristen Wiig als Ruth Buggs |
 | Bill Hader als Haggard |
 | Blythe Danner als Tara Walton |
 | Joe Lo Truglio als O'Reilly |
 | John Carroll Lynch als Moses Buggs |
 | Jane Lynch als Pat Stevenson |
 | David Koechner als Gus |
 | Jesse Plemons als Jake |
 | Sigourney Weaver als The Big Guy |
 | Jeffrey Tambor als Adam Shadowchild |
 | Steven Spielberg als Self |
 | Mia Stallard als Young Tara |
 | Bobby Lee als Valet |
 | Jennifer Granger als Adam Shadowchild Fan |
 | Jeremy Owen als Sword Vendor |
 | David House als Security Guard |
 | Nelson Ascencio als Jorge |
 | Mark Sivertsen als State Trooper |
 | Joe Berryman als Gas Station Attendant |
| Syd Masters als Band Member #1 |
| Gary Roller als Band Member #2 |
| Oliver O'Shea als Band Member #3 |
| Lonnie Otha-Mayer als Band Member #4 |
| Will Veitch als Band Member #5 |
| Mike Miller als Police Officer |
 | Lori Dillen als Robed Woman |
| J. Todd Anderson als Comic Store Clerk |
| Brett Michael Jones als Keith Nash |
| Diego Deane als Fireworks Store Clerk |
| Joel Thingvall als Comic Book Dealer (uncredited) |
 | Robert Amstler als Comic Con Conan (uncredited) |
| Dawn Barber als Sailor Moon (uncredited) |
| Chad Boardsen als Snake Plissken Cosplay (uncredited) |
 | Devin Faraci als Comic Con Nerd (uncredited) |
 | David Fernandez Jr. als Comic Con (uncredited) |
| Larry Goldstein als Comic-Con Chewbacca (uncredited) |
| Zack Kennedy als Comic Con Nerd (uncredited) |
| Chris Kittinger als Bar Patron (uncredited) |
| Jeremiah Krage als Baker (uncredited) |
 | Paula LaBaredas als Princess Leia (uncredited) |
 | Sylvia Adelina Padilla als Felix the Cat (uncredited) |
| Michael Neal Powell als Bartender (uncredited) |
 | Phoebe Price als Princess Lea (uncredited) |
 | Chris Rymer als Comic Con Clone Trooper (uncredited) |
| Joy Sudduth als Angry Stage Manager (uncredited) |
| Brian Ulrich als Gray Uglydoll (uncredited) |
| Eric Fellner | Producer |
| Cheryl Kurk | Production Accountant |
| Liza Chasin | Executive Producer |
| Tania Blunden | Post Production Supervisor |
| Julian Slater | Supervising Sound Editor |
| Lawrence Sher | Director of Photography |
| Andy Hague | Visual Effects Editor |
| Simon Pegg | Writer |
| Tim Bevan | Producer |
| Carla Curry | Set Decoration |
| Catriona Richardson | First Assistant Editor |
| Jody Johnson | Visual Effects Supervisor |
| Anders J.L Beer | Animation Supervisor |
| Natascha Wharton | Executive Producer |
| Peter F. Kurland | Sound mixer |
| Nira Park | Producer |
| Jefferson Sage | Production Design |
| Greg Mottola | Director |
| S. Todd Christensen | Location Manager |
| Nick Frost | Writer |
| Debra Hayward | Executive Producer |
| Hal Couzens | Visual Effects Supervisor |
| Nick Angel | Music Supervisor |
| Chris Dickens | Editor |
| Robert Graf | Executive Producer |
| Robert Graf | Unit Production Manager |
| Allison Jones | Casting |
| Wilson Webb | Still Photographer |
| Nancy Steiner | Costume Design |
| Kate Fasulo | Production Coordinator |
| Darrin Prescott | Stunt Coordinator |
| Steven Price | Music Editor |
| Rachael Lin Gallaghan | Production Coordinator |
| Richard Fojo | Art Direction |
| Jennifer Starzyk | Assistant Costume Designer |
| Dina Eaton | Music Editor |
| David Arnold | Original Music Composer |
| Linda Matthews | Costume Supervisor |
| Mary Burton | Makeup Artist |
| Tarra D. Day | Makeup Department Head |
| Chris Burdon | Sound Re-Recording Mixer |
| Simon Gershon | Sound Effects Editor |
| Nina Paskowitz | Hairstylist |
| Jane Walker | Hairstylist |
| Geordie Sheffer | Hair Department Head |
| John Joyce | Steadicam Operator |
| Doug Cooper | Sound Re-Recording Mixer |
| Brooks Robinson | Steadicam Operator |
| Ben Meechan | Sound Effects Editor |
| Jarred Waldron | Gaffer |
| Glenn E. Moran | Rigging Gaffer |
| Berlinda Cantu-Lewis | Hairstylist |
| Sonny Surowiec | Stunts |
| Edgar Wright | Script Editor |
| Kirsten Lane | Music Consultant |
| Debbie Evans | Stunts |
| Richard Ayoade | Thanks |
| Tad Griffith | Stunts |
| Chris Palermo | Stunt Driver |
| Peter Burgis | Foley Artist |
| Peter Gleaves | ADR Mixer |
| Ruth Sullivan | Foley Artist |
| Barnaby Smyth | Foley Artist |
| Adam Schardein | Producer |
| Greg Nicotero | Special Effects Makeup Artist |
| Natasha Ladek | Wigmaker |
| Georgia Allen | Makeup Artist |
| Al Goto | Stunts |
| Ed Duran | Stunts |
| Tait Fletcher | Stunts |
| Dean Bailey | Stunts |
| Donny Bailey | Stunts |
| Elle Alexander | Stunts |
| Bruce Benson | Stunts |
| Mark Brooks | Stunts |
| Robert Anthony Brass | Stunts |
| Bobby Burns | Stunts |
| Eddie Fiola | Stunts |
| Laurence Chavez | Stunts |
| Nate Harris | Stunts |
| Michael R. Long | Stunts |
| Cory Fleming | Stunts |
| Rich Minga | Stunts |
| Suzanne Prescott | Stunts |
| Angelique Midthunder | Stunts |
| Derick Pritchard | Stunts |
| Rich Rutherford | Stunts |
| Jimmy Romano | Stunts |
| Trina Siopy | Stunts |
| Willie Weber | Stunts |
| Craig Baxley Jr | Stunts |
| Mam Smith | Stunts |
