 | Johnny Depp als Captain Jack Sparrow |
 | Orlando Bloom als Will Turner |
 | Keira Knightley als Elizabeth Swann |
 | Geoffrey Rush als Captain Hector Barbossa |
 | Stellan Skarsgård als William "Bootstrap Bill" Turner |
 | Chow Yun-Fat als Captain Sao Feng |
 | Bill Nighy als Captain Davy Jones |
 | Jack Davenport als Admiral James Norrington |
 | Kevin McNally als Joshamee Gibbs |
 | Tom Hollander als Lord Cutler Beckett |
 | Naomie Harris als Tia Dalma |
 | Jonathan Pryce als Governor Weatherby Swann |
 | Keith Richards als Captain Teague Sparrow |
 | Lee Arenberg als Pintel |
 | Mackenzie Crook als Ragetti |
 | Greg Ellis als Lieutenant Theodore Groves |
 | David Bailie als Cotton |
 | Martin Klebba als Marty |
 | David Schofield als Ian Mercer |
 | Lauren Maher als Scarlett |
 | Vanessa Branch als Giselle |
 | Angus Barnett als Mullroy |
 | Giles New als Murtogg |
 | Reggie Lee als Tai Huang |
 | Dominic Scott Kay als Henry Turner |
 | Takayo Fischer als Mistress Ching |
 | David Meunier als Lieutenant Greitzer |
 | Ho-Kwan Tse als Hadras |
 | Andy Beckwith als Clacker |
 | Peter Donald Badalamenti II als Penrod |
| Christopher S. Capp als Cotton's Parrot (voice) |
 | Hakeem Kae-Kazim als Captain Jocard |
 | Ghassan Massoud als Captain Ammand |
 | Omid Djalili als Aksay / Pusasn |
 | Michelle Lee als Lian |
| Huynh Quang als Pirate |
 | Ned Wertimer als Singing Gallows Pirate |
 | Arnold Chon als Asian Pirate (uncredited) |
| Dariusz Wolski | Director of Photography |
| Gore Verbinski | Director |
| Jerry Bruckheimer | Producer |
| Ted Elliott | Screenplay |
| Ted Elliott | Characters |
| Terry Rossio | Screenplay |
| Terry Rossio | Characters |
| Stuart Beattie | Characters |
| Jay Wolpert | Characters |
| Stephen E. Rivkin | Editor |
| Craig Wood | Editor |
| Hans Zimmer | Original Music Composer |
| Bruce Hendricks | Executive Producer |
| Mike Stenson | Executive Producer |
| Eric McLeod | Producer |
| Eric McLeod | Executive Producer |
| Chad Oman | Producer |
| Chad Oman | Executive Producer |
| Peter Kohn | Producer |
| Peter Kohn | Associate Producer |
| Pat Sandston | Producer |
| Pat Sandston | Associate Producer |
| Denise Chamian | Casting |
| Rick Heinrichs | Production Design |
| John Dexter | Art Direction |
| Sala Baker | Stunts |
| Priscilla John | Casting |
| Cheryl Carasik | Set Decoration |
| Liz Dann | Costume Design |
| Penny Rose | Costume Design |
| Bob Badami | Music Supervisor |
| John Frazier | Special Effects Supervisor |
| William Ladd Skinner | Art Direction |
| Robin Beauchesne | Makeup Artist |
| Richard Alonzo | Makeup Artist |
| Ken Diaz | Makeup Supervisor |
| Ken Diaz | Tattoo Designer |
| Bruce Crone | Art Direction |
| William Hawkins | Art Direction |
| James Ward Byrkit | Conceptual Design |
| Steve Buscaino | Prosthetics |
| Ve Neill | Makeup Department Head |
| Kris Evans | Makeup Artist |
| John Dexter | Supervising Art Director |
| John Dixon | Stunts |
| Dottie Starling | CGI Supervisor |
| Robert Edwards | ADR Recordist |
| Pamela Alch | Script Supervisor |
| Hazel Catmull | Hairstylist |
| Allen Hall | Special Effects Coordinator |
| Melissa Muik | Music Editor |
| Sharron Reynolds-Enriquez | Script Supervisor |
| Barbara McDermott | Music Editor |
| Karen Golden | Script Supervisor |
| John Knoll | Visual Effects Supervisor |
| David Dupuis | Makeup Artist |
| Barbara Cantu | Hairstylist |
| Gloria Pasqua Casny | Key Hair Stylist |
| Jed Dornoff | Makeup & Hair Assistant |
| Hal T. Hickel | Animation Supervisor |
| Donald Dowd | Production Director |
| Charles Gibson | Visual Effects |
| Gabriel De Cunto | Makeup Artist |
| Catherine Childers | Hairstylist |
| Martin Samuel | Hair Designer |
| Steven E. Anderson | Makeup Artist |
| Katie Greathouse | Music Editor |
| Natasha Allegro | Hairstylist |
| Brigham Taylor | Production Executive |
| Leslie Devlin | Makeup Artist |
| Leslie Devlin | Facial Setup Artist |
| Elena Arroy | Makeup Artist |
| Belinda Bryant | Makeup Artist |
| Jack Kney | Producer |
| Geoff Campbell | Character Modelling Supervisor |
| Roxanne Ferguson | Hairstylist |
| Monique DeSart | Hairstylist |
