 | Adrien Brody als Royce |
 | Topher Grace als Edwin |
 | Alice Braga als Isabelle |
 | Oleg Taktarov als Nikolai |
 | Laurence Fishburne als Noland |
 | Walton Goggins als Stans |
 | Danny Trejo als Cuchillo |
 | Louis Ozawa als Hanzo |
 | Mahershala Ali als Mombasa |
 | Brian Steele als Berserker Predator / Falconer Predator |
 | Derek Mears als Classic Predator |
 | Carey Jones als Tracker Predator |
 | Aaron Richardson als Rocky (uncredited) |
| Nimród Antal | Director |
| Alex Litvak | Writer |
| Michael Finch | Writer |
| Robert Rodriguez | Producer |
| Elizabeth Avellan | Producer |
| Alex Young | Executive Producer |
| John Debney | Original Music Composer |
| Gyula Pados | Director of Photography |
| Dan Zimmerman | Editor |
| Nina Proctor | Costume Design |
| John Davis | Producer |
| Jaina Ashton | Casting |
| J.C. Cantu | Casting |
| Mary Vernieu | Casting |
| Gina Grande | Script Supervisor |
| Jim Thomas | Characters |
| Caylah Eddleblute | Production Design |
| Steve Joyner | Production Design |
| David Hack | Set Decoration |
| Ermahn Ospina | Makeup Department Head |
| Joe Rivera | Hair Department Head |
| Brian Bettwy | First Assistant Director |
| Jeff B. Adams Jr. | Set Designer |
| Pedro Barquin | Greensman |
| Richard J. Bell | Greensman |
| Mark Hanks | Leadman |
| Ana Martínez | Art Department Coordinator |
| Joe McCusker | Construction Coordinator |
| Adele Plauche | Set Designer |
| Tommy Tomlinson | Property Master |
| Joaquin Gonzalo Avellán | Foley Editor |
| David Bach | ADR Editor |
| Brad Engleking | Dialogue Editor |
| Paula Fairfield | Sound Designer |
| William Jacobs | Sound Editor |
| Carla Murray | Sound Designer |
| Angelo Palazzo | Sound Effects Editor |
| Tim Rakoczy | Supervising Sound Editor |
| Tom Sturgis | Boom Operator |
| Clayton Weber | Foley Editor |
| Joe Montenegro | Special Effects Coordinator |
| Richard Wood | Special Effects Supervisor |
| Jabbar Raisani | Visual Effects Supervisor |
| Travis Smith | Visual Effects Editor |
| jonathan Swartz | Lighting Director |
| Sean Noel Walker | Lighting Director |
| Jeffrey J. Dashnaw | Stunt Coordinator |
| Steve M. Davison | Stunt Coordinator |
| Colin J. Campbell | Gaffer |
| Neil Fraser | Dolly Grip |
| Mark Gerasimenko | Camera Operator |
| Spencer Pharr | Lighting Technician |
| Ferrell A. Shinnick | Key Grip |
| Henry Tirl | Steadicam Operator |
| Rico Torres | Still Photographer |
| Amy Maner | Costume Supervisor |
| Cindy Renaud-Kim | Tailor |
| Logan Cooper | Location Manager |
| Jeff Carson | Music Editor |
| Brad Dechter | Orchestrator |
| Cynthia Streit | Production Coordinator |
| Kurt Volk | Title Designer |
| Larry Zanoff | Armorer |
| Francois Larosa | Greensman |
| John Thomas | Characters |
| Tom Proper | Associate Producer |
| Bill Scott | Co-Producer |
| Tom Proper | Post Production Supervisor |
| Ron Schmidt | Unit Production Manager |
| Susan Jasso | Second Second Assistant Director |
| David Rimer | Second Assistant Director |
| Troy Robinson | Stunts |
| Bob Brown | Stunts |
| Heidi Pascoe | Stunt Double |
| Tim Trella | Stunts |
