 | Wentworth Miller als Michael Scofield |
 | Sarah Wayne Callies als Sara Tancredi |
 | Dominic Purcell als Lincoln Burrows |
 | Jodi Lyn O'Keefe als Gretchen Morgan |
 | Amaury Nolasco als Fernando Sucre |
 | Robert Knepper als Theodore 'T-Bag' Bagwell |
 | William Fichtner als Alex Mahone |
 | Amy Aquino als Warden Alice Simms |
 | Lori Petty als Daddy |
 | Kim Coates als Agent Richard Sullins |
 | Barbara Eve Harris als FBI Agent Felicia Lang |
 | Chris Bruno als Agent Todd Wheatley |
 | David Starzyk als Blue Phillips |
 | Aisha Hinds als Guard Cowler |
 | Jeff Cahill als Snee |
 | Dendrie Taylor als Blonde Guard |
 | Damien Leake als Detective Marlin |
 | Livia Treviño als Hucks |
 | Alicia Lagano als Agatha |
 | Dot-Marie Jones als Skittlez |
 | Kathleen Quinlan als Christina Rose Scofield |
 | Adrienne McQueen als Prison Guard (uncredited) |
| 'Big' LeRoy Mobley als Hotel Security Guard (uncredited) |
| Kevin Hooks | Director |
| Brad Turner | Director |
| Randy Glass | Gaffer |
| Neal H. Moritz | Executive Producer |
| John McGonegle | Assistant Chief Lighting Technician |
| Michael Klick | Producer |
| Marty Adelstein | Executive Producer |
| Garry A. Brown | Producer |
| Zack Estrin | Co-Executive Producer |
| Kevin Hooks | Executive Producer |
| Matt Olmstead | Executive Producer |
| Dawn Olmstead | Executive Producer |
| Brett Ratner | Executive Producer |
| Nick Santora | Co-Executive Producer |
| Paul T. Scheuring | Executive Producer |
| Karyn Usher | Co-Executive Producer |
| Agatha Aro Warren | Co-Producer |
| Nicholas Wootton | Consulting Producer |
| Ramin Djawadi | Original Music Composer |
| Fernando Argüelles | Director of Photography |
| Jeffrey C. Mygatt | Director of Photography |
| Etienne Des Lauriers | Editor |
| Eric Seaburn | Editor |
| Scott Genkinger | Casting |
| Deborah George | Casting |
| Junie Lowry-Johnson | Casting |
| Philip Leonard | Production Design |
| Jackie Carr | Set Decoration |
| Taneia Lednicky | Costume Design |
| Carl Bailey | Hair Department Head |
| Nanette Moore | Makeup Department Head |
| Nick Santora | Teleplay |
| Zack Estrin | Teleplay |
| Karyn Usher | Teleplay |
| Seth Hoffman | Executive Story Editor |
| Seth Hoffman | Teleplay |
| Christian W. Trokey | Story Editor |
| Kalinda Vazquez | Story Editor |
| Christian W. Trokey | Teleplay |
| Kalinda Vazquez | Teleplay |
