 | Sylvester Stallone als John Rambo |
 | Julie Benz als Sarah |
 | Matthew Marsden als School Boy |
 | Graham McTavish als Lewis |
 | Reynaldo Gallegos als Diaz |
 | Tim Kang als En-Joo |
 | Jake La Botz als Reese |
 | Maung Maung Khin als Tint |
 | Paul Schulze als Michael Burnett |
 | Cameron Pearson als Jeff |
| Thomas Peterson als Dentist |
| Tony Skarberg als Videographer |
 | James With als Preacher |
| Kasikorn Niyompattana als Snake Hunter #2 |
| Shaliew 'Lek' Bamrungbun als Snake Hunter #1 |
 | Supakorn Kitsuwon als Myint |
 | Aung Aay Noi als Lt. Aye |
 | Ken Howard als Arthur Marsh |
 | Aung Theng als Pirate Leader |
| Pornpop 'Tor' Kampusiri als Snake Village Owner |
| Wasawat Panyarat als Snake Village MC |
| Kammul Kawtep als Snake Village Young Charmer |
| Sornram Patchimtasanakarn als Tha |
| Noa 'Arunee Prijareonsuk' Jei als Karen Interpreter |
| Kjam Saen als Karen Interpreter #2 |
| Aun Lung Su als Burmese Hut Guard #1 |
| Pan Dokngam als Burmese Hut Guard #2 |
| Han Pik als Burmese Hut Guard #3 |
| Tip Tiya als Burmese Gate Guard #2 |
| Nee Lungjai als Burmese Gate Guard |
| Yupin Mu Pae als Karen Begging Mother |
| Moan Adisak als Burmese Morning Guard #1 |
| Somsak Wongsa als Burmese Dancer Trooper #1 |
| Surachai Muangdee als Burmese Dancer Trooper #2 |
| Mana Sen-Mi als Burmese Patrol Boat Captain |
| Toole Khan Kham als Burmese Sergeant |
| Saiwan Lungta als Burmese Trooper - Lt. Aye's Hut |
| Watcharentr Sedtho als Burmese Young Boy |
| Rapimpa Dibu als Karen Young Naked Girl |
| May Kung als Pirate Bar Hooker #1 |
 | George Cheung als Tay (archive footage) (uncredited) |
 | Richard Crenna als Col. Samuel Trautman (archive footage) (uncredited) |
 | Matthew Wolf als BBC Reporter (uncredited) |
| Bob Weinstein | Executive Producer |
| Harvey Weinstein | Executive Producer |
| Brian Tyler | Original Music Composer |
| Sheila Jaffe | Casting |
| Peter Block | Executive Producer |
| Sylvester Stallone | Screenplay |
| Sylvester Stallone | Director |
| Kevin King Templeton | Producer |
| Sean Albertson | Editor |
| Franco-Giacomo Carbone | Production Design |
| Boaz Davidson | Executive Producer |
| David Morrell | Original Story |
| Avi Lerner | Producer |
| George Furla | Executive Producer |
| Randall Emmett | Executive Producer |
| Leslie Shatz | Sound Re-Recording Mixer |
| John Thompson | Producer |
| Glen MacPherson | Director of Photography |
| Trevor Short | Executive Producer |
| Danny Dimbort | Executive Producer |
| Josef Lautenschlager | Co-Producer |
| Andreas Thiesmeyer | Executive Producer |
| Art Monterastelli | Screenplay |
| Joachim Sturmes | Co-Producer |
| Derek Vanderhorst | Sound Effects Editor |
| Christopher Petzel | Associate Producer |
| Jon Feltheimer | Executive Producer |
| Scott K. Wallace | Additional Editor |
| Kevin Bernhardt | Co-Producer |
| Russell D. Markowitz | Line Producer |
| Gary Krause | Music Editor |
| Chris David | Sound Re-Recording Mixer |
| Scott Coulter | Visual Effects Producer |
| Phasiri Panya | Casting |
| Lizz Wolf | Costume Design |
| Matthew O'Toole | Line Producer |
| Kyle Billingsley | Foley Mixer |
| Jeff Toyne | Orchestrator |
| Gilles Corbeil | Steadicam Operator |
| John Schoonraad | Prosthetic Supervisor |
| John Schoonraad | Prosthetics |
| Scott H. Eddo | Makeup Department Head |
| Preeyanan Suwannathada | Wardrobe Assistant |
| Kent H. Johnson | Property Master |
| Donald Flick | Sound Editor |
| Jordan Markov | Visual Effects Editor |
| Joe Lisanti | Music Editor |
| Wes C. Caefer | Visual Effects Supervisor |
| Nikolay Gachev | Visual Effects Supervisor |
| Perry Robertson | Supervising Sound Editor |
| Jaclyn Tamizato | Assistant Costume Designer |
| Barney Cabral | Supervising Sound Editor |
| Allan Levine | Digital Intermediate Producer |
| Suchartanun 'Kai' Kuladee | Art Direction |
| Witoon Suanyai | Set Decoration |
| Somm Suthinee Chantakarn | Art Department Coordinator |
| Gabriel J. Serrano | Sound Recordist |
| Simeon Asenov | Visual Effects Art Director |
| Richard Osborn Jr. | First Assistant Camera |
| Rickley W. Dumm | Sound Effects Editor |
| John K. Stirber | Special Effects Supervisor |
| Michelle Pazer | ADR Editor |
| Jimi Johnson | Video Assist Operator |
| Marshall Garlington | Sound Re-Recording Mixer |
| Veselina Georgieva | Visual Effects Supervisor |
| Evan Schiff | Assistant Editor |
| Craig W. Smith | First Assistant Editor |
| Harry Muller | Color Timer |
| Richard Dwan Jr. | Supervising Dialogue Editor |
| Migs Rustia | Visual Effects Editor |
| Paul Stemmer | Visual Effects Editor |
| Nicole Venables | Key Hair Stylist |
| David Graubard | Digital Intermediate |
| Michael Galbraith | Gaffer |
| Tom Starnes | Rigging Gaffer |
| Karen Ballard | Still Photographer |
| Scott Sanders | Sound Designer |
| Scott Sanders | Supervising Sound Editor |
| Vern Nobles | Additional Photography |
| Jon Pehlke | Digital Intermediate Editor |
| Nick Peshunoff | Visual Effects Coordinator |
| Navarutt Roongaroon | Script Supervisor |
| Rebecca Poulos | Script Supervisor |
| Brandi Hugo | Art Department Coordinator |
| Daniel Page McDonough | Camera Operator |
| Nona Khodai | Assistant Editor |
| Christy Wyatt | Assistant Hairstylist |
| Desislava Lazarova | Visual Effects Editor |
| Robert Elhai | Orchestrator |
| Susan Paley Abramson | Casting Associate |
| Florian Lechner | Executive Producer |
| Selena Arizanovic | Music Coordinator |
| Danny S. Kim | Visual Effects Supervisor |
| Rittikorn Manonom | Camera Operator |
| Maneerath Vijob | Key Hair Stylist |
| Watana Garum | Makeup Artist |
| Petko Zhivkov | Digital Compositor |
| Nick Neutra | Foley Supervisor |
| Kevin Zimmerman | First Assistant Sound Editor |
| Chidchanok Plodripu | Transportation Coordinator |
| Stanislav Dragiev | Visual Effects Supervisor |
| Annop Jaikaew | Boom Operator |
| Harry Lu | Armorer |
| Vasit Suchitta | Prosthetics |
| Jeanmarie Murphy-Burke | Unit Publicist |
| Alexander Gunn | Special Effects Supervisor |
| Ivaylo Andonov | Digital Compositor |
| Svilen Aynadzhiev | Digital Compositor |
| Ivelina Dobreva | Digital Compositor |
| Anton Donchev | Digital Compositor |
| Kiril Gizdov | Digital Compositor |
| Rosen Ivanov | Digital Compositor |
| Momchil Kirov | Digital Compositor |
| Diana Moneva | Digital Compositor |
| Maria Popova | Digital Compositor |
| Yakim Petrov | Animation |
| Nikolay Mihailov | Digital Compositor |
| Milena Peneva | Visual Effects Coordinator |
| Julia Petrova | Digital Compositor |
| Paul Bronkar | Digital Intermediate Colorist |
| Chris Ward | Digital Intermediate Producer |
| Greg Chapman | Sound Mixer |
| Daren Bailey | Marine Coordinator |
| Plamen Statev | Visual Effects Coordinator |
| Pat Cassin | Boom Operator |
| Sawang Yodnen | Pyrotechnician |
| James Bailey | Foley Artist |
| Tanawat Punya | Extras Casting |
| Eric Thompson | ADR Mixer |
| Audrey A. Johnson | Assistant Property Master |
| Peter Tomov | Visual Effects Supervisor |
| Christine Reins | Assistant Art Director |
| Pipat Sripradoo | On Set Dresser |
| Mark Brooks | On Set Dresser |
| Kenny Groom | Assistant Camera |
| Chesda 'Pop' Smithsuth | Gaffer |
| Anusorn Poonsup | Grip |
| Boonleang Thaisaman | Grip |
| Michael E. Matteson | Key Grip |
| Pat Liampetchakul | Rigging Grip |
| Ron Veto | Steadicam Operator |
| Piyathida Phorung | Assistant Hairstylist |
| Makoree Waekaji | Assistant Makeup Artist |
| Sayun Santon | Hairstylist |
| Ngamta Somboon | Makeup Artist |
| Matt Rubenstein | Casting Assistant |
| Sean Gundlach | Costume Supervisor |
| Pawin Chantanimi | Marine Coordinator |
| Wanchai 'Jockey' Jaipongsai | Transportation Captain |
| David Walters | Digital Intermediate |
| Boyan Stoyanov | Animation |
| Lyubomir Grigorov | Concept Artist |
| Konstantin Dimitrov | Digital Compositor |
| Denitsa Dimitrova | Digital Compositor |
| Albena Ivanova | Digital Compositor |
| Milan Stoyanov | Digital Compositor |
| Dimitrina Torneva | Digital Compositor |
| Desislava Valcheva | Digital Compositor |
| Elin Davidov | Matte Painter |
| Momchil Koev | Visual Effects Compositor |
| Velichko Ivanov | Visual Effects Supervisor |
| Gerald McCrory | Pyrotechnician |
| Tristan Schoonraad | Pyrotechnician |
| Rangsun Rangsimaporn | Special Effects Coordinator |
