 | Jamie Foxx als Ray Charles |
 | Kerry Washington als Della Bea Robinson |
 | Regina King als Margie Hendricks |
 | Harry Lennix als Joe Adams |
 | Clifton Powell als Jeff Brown |
 | Bokeem Woodbine als Fathead Newman |
 | Sharon Warren als Aretha Robinson |
| C.J. Sanders als Young Ray Robinson |
 | Curtis Armstrong als Ahmet Ertegun |
 | Richard Schiff als Jerry Wexler |
 | Larenz Tate als Quincy Jones |
 | Terrence Howard als Gossie McGee |
 | David Krumholtz als Milt Shaw |
 | Wendell Pierce als Wilbur Brassfield |
 | Aunjanue Ellis-Taylor als Mary Ann Fisher |
 | Chris Thomas King als Lowell Fulson |
| Thomas Jefferson Byrd als Jimmy |
 | Rick Gomez als Tom Dowd |
 | Denise Dowse als Marlene |
 | Warwick Davis als Oberon |
 | Patrick Bauchau als Dr. Hacker |
 | Robert Wisdom als Jack Lauderdale |
 | Kurt Fuller als Sam Clark |
| Jedda Jones als Mercedes |
 | Gary Grubbs als Billy Ray |
 | Carol Sutton als Eula |
 | Paula Jai Parker als Ruth Brown |
| Eric O'Neal Jr. als Ray Charles Jr. - 5-6 Yrs. |
 | Tequan Richmond als Ray Charles Jr. - 9-10 Yrs. |
 | Ayanna Tatum als Woman in Sandpiper Lounge (uncredited) |
| Taylor Hackford | Director |
| James L. White | Screenplay |
| Barbara A. Hall | Line Producer |
| Stephen Altman | Production Design |
| Mary Frances Eglin | Art Department Coordinator |
| James L. White | Story |
| Taylor Hackford | Story |
| Nancy Klopper | Casting |
| Paweł Edelman | Director of Photography |
| Craig Armstrong | Original Music Composer |
| Sharen Davis | Costume Design |
| Maria Nay | Set Decoration |
| Scott Plauche | Art Direction |
| Curt Sobel | Music Supervisor |
| Per Hallberg | Supervising Sound Editor |
| Karen Baker Landers | Supervising Sound Editor |
| Pamela Alch | Script Supervisor |
| Nicola Goode | Still Photographer |
| Stuart Benjamin | Producer |
| Karen Elise Baldwin | Producer |
| Howard Baldwin | Producer |
| Taylor Hackford | Producer |
| William J. Immerman | Executive Producer |
| Jaime Rucker King | Executive Producer |
| Nick Morton | Co-Producer |
| Alise Benjamin | Co-Producer |
| Ray Charles Robinson Jr. | Co-Producer |
| JoAnn Stafford-Chaney | Hair Department Head |
| Stacye P. Branche | Makeup Department Head |
| Yvonne Yaconelli | Production Supervisor |
| Jeff Galpin | Stunt Coordinator |
| Paul Hirsch | Editor |
| Camille Friend | Hairstylist |
| John Bucklin | Supervising Art Director |
| Kimaree Long | Dialogue Editor |
| Frederick H. Stahly | Dialogue Editor |
| Anthony Maccario | Property Master |
| Anna MacKenzie | ADR Editor |
| Michelle Pazer | ADR Editor |
| Christopher Assells | Sound Effects Editor |
| Bruce Tanis | Sound Effects Editor |
| Dino DiMuro | Sound Effects Editor |
| Scott Sanders | Sound Effects Editor |
| Peter Staubli | Sound Effects Editor |
| Dan Hegeman | Sound Effects Editor |
| Christopher Moriana | Foley Artist |
| Catherine Harper | Foley Artist |
| James Moriana | Foley Artist |
| Jeffrey Wilhoit | Foley Artist |
| Steve Cantamessa | Production Sound Mixer |
| Bob Beemer | Sound Mixer |
| Greg Orloff | Sound Mixer |
| Scott Millan | Sound Mixer |
| Nerses Gezalyan | Foley Mixer |
| Raymond Prado | Second Unit Director |
| Jerry Grandey | First Assistant Director |
| Chris Jargo | ADR Supervisor |
