 | Kaya Scodelario als Claire Redfield |
 | Hannah John-Kamen als Jill Valentine |
 | Robbie Amell als Chris Redfield |
 | Tom Hopper als Albert Wesker |
 | Avan Jogia als Leon Kennedy |
 | Donal Logue als Chief Irons |
 | Neal McDonough als William Birkin |
 | Lily Gao als Ada Wong |
 | Chad Rook als Richard Aiken |
 | Marina Mazepa als Lisa Trevor |
 | Nathan Dales als Vickers |
 | Josh Cruddas als Ben Bertolucci |
 | Pat Thornton als Truck Driver |
 | Holly de Barros als Sherry Birkin |
 | Janet Porter als Annette Birkin |
 | Lily Gail Reid als Young Claire |
 | Daxton Gujral als Young Chris |
 | Dylan Taylor als Kevin Dooley |
 | Sammy Azero als Enrico Marini |
 | Jenny Young als Waitress / Louise |
 | Stephannie Hawkins als Sickly Mother |
| Nathaniel McParland als Sickly Boy |
 | Pamela MacDonald als Nurse |
| Heloise Catherine Pead Galvin als Ashford Twin #1 |
| Sophia Ann Pead Galvin als Ashford Twin #2 |
 | Kalie Hunter als Chernobyl Zombie #1 |
 | Andrea Ciacci als Chernobyl Zombie #2 |
 | Kelly Reich als Female in Crowd (RCPD) |
| Robert Chaumont als Man in Crowd (RCPD) |
| Matthew MacCallum als Labcoat Zombie / Dining Hall Chernobyl Zombie #1 |
| Jason Lee Bell als Dining Hall Chernobyl Zombie #2 |
 | Avaah Blackwell als Dooley’s Zombie (uncredited) |
 | Carson Manning als Orderly (uncredited) |
| Johannes Roberts | Director |
| Robert Kulzer | Producer |
| Hartley Gorenstein | Producer |
| Martin Moszkowicz | Executive Producer |
| Victor Hadida | Executive Producer |
| James Harris | Producer |
| Maxime Alexandre | Director of Photography |
| Dev Singh | Editor |
| Jennifer Spence | Production Design |
| Jennifer Lantz | Costume Design |
| Paul W. S. Anderson | Executive Producer |
| Anthony Ianni | Art Direction |
| Kalene Osborne | Casting Associate |
| Faith Campbell | Costume Assistant |
| Cayley Jensen | Costume Set Supervisor |
| Minda Johnson | Costume Supervisor |
| Alisha Robinson | Costume Supervisor |
| Sara Sahr | Costume Assistant |
| Mara Zigler | Costume Coordinator |
| Bill Ferwerda | Colorist |
| Phil Canning | Music Supervisor |
| Samantha McMeekin | Script Supervisor |
| Bj Prince | Animal Wrangler |
| Andre Coutu | Post Producer |
| Daniel Carrasco | Creature Design |
| Kevin Carter | Contact Lens Painter |
| Emma-Lee Hilton | Prosthetic Makeup Artist |
| Dann Campbell | Assistant Hairstylist |
| Ashley Nay | Key Hair Stylist |
| Jerrett Zaroski | Post Production Supervisor |
| Bruno Rocca | Art Direction |
| Allan Cooke | Special Effects Makeup Artist |
| Kayla Dobilas | Special Effects Makeup Artist |
| Joseph Hinds | Assistant Makeup Artist |
| Shaun Hunter | Prosthetics |
| Paul Jones | Special Effects Makeup Artist |
| Neil Morrill | Special Effects Makeup Artist |
| Steve Newburn | Prosthetic Designer |
| Daniella Pluchino | Makeup Artist |
| Steph Pringle | Key Makeup Artist |
| Hailey Roseland-Barnes | Makeup Artist |
| Erin Sweeney | Makeup Department Head |
| Anthony Veilleux | Sculptor |
| Anthony Veilleux | Prosthetics |
| Mark Wotton | Special Effects Makeup Artist |
| Scott Strauss | Executive In Charge Of Production |
| Luke Ellis | Dresser |
| Randi Lee Butcher | Assistant Art Director |
| Mira Apci | Set Designer |
| Ruby Gibson | Coordinating Producer |
| Paul Grimard | Graphic Designer |
| Paul Grimard | Props |
| Gerry Kingsley | Digital Compositor |
| Mark Kowalsky | Set Designer |
| Jesse Lagace | Painter |
| Bruno Rocca | Graphic Designer |
| Margaret Shain | Set Dresser |
| Shelley Silverman | Set Designer |
| Christian Urdapilleta | Concept Artist |
| Daniel Lacroix | On Set Dresser |
| Frankie Ovis | Art Department Trainee |
| Lori Paradis | Key Scenic Artist |
| Craig Baker | Boom Operator |
| Jordan Bell | ADR Engineer |
| Ryan Cox | Utility Sound |
| Benjamin Darier | ADR Mixer |
| Jesse Fellows | ADR Recordist |
| Andrew Tay | Sound Mixer |
| Brian Power | ADR Supervisor |
| David Ottier | Utility Sound |
| Dashen Naidoo | Sound Designer |
| Daniel Moctezuma | Foley Recordist |
| Jack Madigan | Assistant Sound Editor |
| Bret Killoran | Sound Mixer |
| Thomas Hayek | Sound Mixer |
| Nelson Ferreira | Supervising Sound Editor |
| Renan Deodato | Mix Technician |
| Hugh Goodden | Additional Photography |
| Jeff Skochko | Special Effects Supervisor |
| Jeff Skochko | Additional Photography |
| Bruce Stanfield | Special Effects Assistant |
| Ève Corrêa-Guedes | Dialogue Editor |
| Matthew Beightol | Visual Effects Compositor |
| Jo Hughes | Visual Effects Supervisor |
| Brittany Hurrell | Data Wrangler |
| Troy Robinson | Cyber Scanning Supervisor |
| Jubinville Steve | Modeling |
| Alex Armbruster | Stunt Double |
| Jason Lee Bell | Utility Stunts |
| Geoff Meech | Stunt Double |
| Bas Reitsma | Stunt Double |
| Bas Reitsma | Stunt Driver |
| Aj Risi | Stunt Double |
| Mike Chute | Stunt Driver |
| Dan MacDonald | Stunts |
| Vincent Rother | Stunts |
| Andrew Butcher | Stunts |
| Avaah Blackwell | Stunts |
| Randy Butcher | Stunts |
| Stephannie Hawkins | Stunts |
| Sharon Canovas | Stunts |
| Sebastian Buitrago | Stunts |
| Neven Pajkic | Stunts |
| Ana Shepherd | Stunt Double |
| Don Stockford | Stunt Double |
| Geoff Scovell | Stunts |
| Dan Skene | Stunt Coordinator |
| Amy Szoke | Stunt Double |
| E. Nova Zatzman | Stunt Double |
| Sean Skene | Stunts |
| Nick Stead | Stunts |
| Tyler Emms | Key Grip |
| John Gallagher | Gaffer |
| Axel Green | Dolly Grip |
| Matt Irwin | Additional Photography |
| Matt Irwin | Assistant Director of Photography |
| Matt Irwin | Camera Operator |
| Shawn Kazda | Best Boy Grip |
| Darian Loohuizen | Camera Trainee |
| Ryan Prouse | Assistant Camera |
| Adam Stewart | Lighting Supervisor |
| Kierstin Zoratto | Second Assistant "A" Camera |
| Michael Fisher | Assistant Camera |
| Paul T. Brooks | Assistant Editor |
| Danielle Dmytraszko | Post Production Coordinator |
| Dave Muscat | Additional Colorist |
| Patrick Perron | Online Editor |
| Adrian Saywell | Online Editor |
| Lawrence Van Beek | Production Assistant |
| Laura Pettitt | Unit Publicist |
| Brandon Mayer | Travel Coordinator |
| Tessa Sawchuk | Assistant Production Coordinator |
| Norbert Hermannstädter | Finance |
| Stephanie Aubertin | Stand In |
| Olivia Gudaniec | Stand In |
| Cora Gillespie | Actor's Assistant |
| Alina Ducharme Dockery | Production Coordinator |
| Melissa Covey | Production Assistant |
| Christina Cameron | Production Assistant |
| Richard Barlow | Production Assistant |
| Cassandra Barbour | Clearances Consultant |
| Antje Bankmann | Finance |
| Tanner Brazier | Assistant Accountant |
| Lidia Castellano | Production Assistant |
| Donald Colafranceschi | Production Coordinator |
| Alexander Hamilton Westmore | Production Assistant |
| Luke Auger | Cast Driver |
| Dalton Haskin | Transportation Coordinator |
| Nick Haskin | Cast Driver |
| Adam Bocknek | Second Assistant Director |
| Chris Feltis | Assistant Director |
| Abel Erazo-Ibarra | Assistant Director |
| Adam Singer | Set Production Assistant |
| Alessia Spalvieri | Assistant Director |
| Vanessa Smith | Makeup Artist |
| Colin Jones | Casting |
| Mark Korven | Original Music Composer |
| Jeremy Bolt | Executive Producer |
| Johannes Roberts | Writer |
| Bret Killoran | Sound Re-Recording Mixer |
| Andrew Tay | Sound Re-Recording Mixer |
| Hiroyuki Kobayashi | Associate Producer |
| Alex Zhang | Co-Executive Producer |
| Sara Kay | Casting |
| Hartley Gorenstein | Unit Production Manager |
| Christine Sola | Production Manager |
| Jenny Lewis | Local Casting |
