 | Elizabeth Daily als Tommy Pickles (voice) |
 | Nancy Cartwright als Chuckie Finster (voice) |
 | Kath Soucie als Phil DeVille / Lil DeVille / Betty DeVille (voice) |
 | Dionne Quan als Kimi Watanabe-Finster (voice) |
 | Tim Curry als Nigel Thornberry (voice) |
 | Joe Alaskey als Lou Pickles (voice) |
 | Tress MacNeille als Charlotte Pickles (voice) |
 | Michael Bell als Drew Pickles / Charles 'Chaz' Finster, Sr. (voice) |
 | Julia Kato als Kira Watanabe-Finster (voice) |
 | Phil Proctor als Howard DeVille (voice) |
 | Jack Riley als Stuart 'Stu' Pickles (voice) |
 | Tara Strong als Dil Pickles (voice) |
 | Cree Summer als Susie Carmichael (voice) |
 | Cheryl Chase als Angelica Pickels (voice) |
 | Melanie Chartoff als Didi Pickles (voice) |
 | Lacey Chabert als Eliza Thornberry (voice) |
 | Danielle Harris als Debbie Thornberry (voice) |
 | Jodi Carlisle als Marianne Thornberry (voice) |
 | Flea als Donnie Thornberry (voice) |
 | Tom Kane als Darwin (voice) |
 | Bruce Willis als Spike (voice) |
 | Tony Jay als Dr. Lipschitz (voice) |
 | Ethan Phillips als Toa (voice) |
 | Chrissie Hynde als Siri (voice) |
| John Eng | Director |
| Norton Virgien | Director |
| Marco Cinello | Background Designer |
| José Antonio García Villameriel | Visual Effects |
| Beth S. Morris | Technical Supervisor |
| Heiko von Drengenberg | Layout |
| Frans Vischer | Sequence Supervisor |
| Larry White | Animation |
| Leonard F.W. Green | Visual Effects |
| Louie C. Jhocson | Animation Manager |
| Greg Tiernan | Sequence Supervisor |
| Rick Moser | Technical Supervisor |
| Brice Mallier | Visual Effects |
| Silvia Pompei | Layout |
| Sharon Ross | Art Department Manager |
| Jay Jackson | Layout |
| Adam Henry | Layout |
| Roberto Casale | Animation |
| Jim Ovelmen | Animation |
| Jim Ovelmen | Visual Effects |
| Kate Boutilier | Writer |
| Arlene Klasky | Producer |
| Gábor Csupó | Producer |
| Albie Hecht | Executive Producer |
| Julia Pistor | Executive Producer |
| Eryk Casemiro | Executive Producer |
| Hal Waite | Executive Producer |
| Tracy Kramer | Co-Producer |
| Terry Thoren | Co-Producer |
| Mark Mothersbaugh | Original Music Composer |
| John Bryant | Editor |
| Kimberly Rettberg | Editor |
| Dima Malanitchev | Production Design |
| Barry Atkinson | Art Direction |
| Howard E. Baker | Sequence Supervisor |
| Priit Pärn | Co-Director |
