 | Cary Elwes als Dr. Lawrence Gordon |
 | Leigh Whannell als Adam Faulkner-Stanheight |
 | Danny Glover als David Tapp |
 | Monica Potter als Alison Gordon |
 | Ken Leung als Detective Steven Sing |
 | Makenzie Vega als Diana Gordon |
 | Michael Emerson als Zep Hindle |
 | Shawnee Smith als Amanda Young |
 | Dina Meyer als Allison Kerry |
 | Alexandra Bokyun Chun als Carla |
 | Tobin Bell als John Kramer / Jigsaw |
 | Mike Butters als Paul |
 | Paul Gutrecht als Mark |
 | Benito Martinez als Brett |
 | Ned Bellamy als Jeff Ridenhour |
| Avner Garbi als Father |
| Hans Raith als Detective (uncredited) |
 | Oren Koules als Dead Cellmate (uncredited) |
| Charlie Clouser | Original Music Composer |
| Gregg Hoffman | Producer |
| Amy Lippens | Casting |
| David A. Armstrong | Director of Photography |
| Kevin Greutert | Editor |
| James Wan | Director |
| Mark Burg | Producer |
| Oren Koules | Producer |
| Jonathan Miller | Sound Designer |
| Leigh Whannell | Writer |
| Nanet Harty | Art Direction |
| Jennifer L. Soulages | Costume Design |
| Julie Berghoff | Production Design |
| Eleanor Sabaduquia | Makeup Department Head |
| Jonathan Miller | Supervising Sound Editor |
| Peter Block | Executive Producer |
| Stacey Testro | Executive Producer |
| Daniel J. Heffner | Co-Producer |
| Lark Bernini | Associate Producer |
| Richard H. Prince | Co-Producer |
| Jason Constantine | Executive Producer |
| James Wan | Story |
| Leigh Whannell | Story |
| Rocky Faulkner | Prosthetic Supervisor |
| Thomas Kuo | Electrician |
| Yaron Levy | Gaffer |
| Josh Harrison | First Assistant Camera |
| Bill Persaud | Rigging Grip |
| Jennifer Levy | Casting Associate |
| Chris Gordon | Grip |
| Randy Babajtis | Sound Effects Editor |
| Thomas L. Bellissimo | Special Effects Supervisor |
| Richard H. Prince | Production Manager |
| Speed Ratliff | Boom Operator |
| Timothy Feimster | Carpenter |
| Bill Davis | Property Master |
| Cameron Allan | Music Editor |
| Derek Bird | Digital Compositors |
| Tricia Sherwood | Craft Service |
| Andrew Patterson | Dialogue Editor |
| Chuck Radtke | Production Intern |
| Brandon Cunningham | Best Boy Electric |
| Andrew Midgley | Visual Effects Producer |
| Marlo Pabon | Visual Effects Supervisor |
| Greg Gayne | Still Photographer |
| Kashka Banjoko | Hairstylist |
| Monica Muehlhause-Horn | Production Accountant |
| Jonathan Scott Miller | Music Supervisor |
| Michelle Rene Elam | Key Hair Stylist |
| Keith Adams | Stunt Coordinator |
| Daniel J. Heffner | First Assistant Director |
| Vicky Choy | Production Coordinator |
| Oscar Garcia | Key Grip |
| Summer Ramsey | Scenic Artist |
| Tory Mell | Set Production Assistant |
| Dan Muscarella | Color Timer |
| John Taylor | Sound Mixer |
| Mark Allan | Visual Effects Coordinator |
| Ian Elias | Post Production Assistant |
| Martin Glover | Video Assist Operator |
| Jill Bream | Art Department Assistant |
| Kathleen Russo | Costume Supervisor |
| Scott H. Eddo | Makeup Artist |
| Lisa Villaire | Camera Loader |
| Jillian Giacomini | Script Supervisor |
| Jon Myers | Camera Operator |
| Andy Steinman | Second Unit Director of Photography |
| Ray Skinner | Electrician |
| John Loveall | Best Boy Grip |
| Michael Steffen | Dolly Grip |
| John Coniglio | Assistant Editor |
| Jeffrey Reyes | Assistant Property Master |
| Robert Beebe | Title Designer |
| Rebecca Rienks | Music Coordinator |
| Alexis Ross | Production Assistant |
| Christina DeMasi | Costumer |
| Shelley Roden | Foley Artist |
| Sherry Kecskes | Assistant Accountant |
| Alan Freedman | ADR Mixer |
| Mocean Melvin | Stunt Driver |
| Jeremy Balko | Foley Mixer |
| Alex Franklin | Production Secretary |
| Luis A. Arevalos | Swing |
| Todd Baldi | Second Assistant Camera |
| Mark Griffith | Digital Intermediate Colorist |
| Charles Belardinelli | Special Effects Assistant |
| Lisa S. Beasley | Extras Casting |
| Eric Gorfain | Music Arranger |
| Kenny Selko | Key Set Production Assistant |
| Alexa Sheehan | Second Assistant Director |
| Jake Blecha | Swing |
| Richard Redlefsen | Assistant Makeup Artist |
