 | Freddie Prinze Jr. als Fred Jones |
 | Sarah Michelle Gellar als Daphne Blake |
 | Matthew Lillard als Norville 'Shaggy' Rogers |
 | Linda Cardellini als Velma Dinkley |
 | Rowan Atkinson als Emile Mondavarious |
 | Miguel A. Núñez Jr. als Voodoo Maestro |
 | Isla Fisher als Mary Jane |
 | Steven Grives als N' Goo Tuana |
 | Charles Stan Frazier als Sugar Ray |
 | Craig Bullock als Sugar Ray |
 | Matthew Murphy Karges als Sugar Ray |
 | Mark McGrath als Sugar Ray |
 | Rodney Sheppard als Sugar Ray |
 | Sam Greco als Zarkos |
| Charlie Cousins als Velma's Friend |
 | Kristian Schmid als Brad |
 | Nicholas Hope als Old Man Smithers |
 | Neil Fanning als Scooby-Doo (voice) |
 | Scott Innes als Scrappy-Doo (voice) |
| J.P. Manoux als Scrappy Rex (voice) |
 | Chris Cruickshanks als Tiny Henchman |
| Alex Ruiz als Reporter #1 |
| Sheryl Benko als Reporter #2 |
| Rio Nugara als Island Emissary |
 | David Vallon als Bartender Dead Mike's |
 | Troy MacKinder als Guy in the Vat |
 | Michala Banas als Carol |
| Holly Brisley als Training Video Woman |
| Robert Díaz als Training Video Guy #1 |
 | Remi Broadway als Training Video Guy #2 |
 | Martin Broome als Melvin Doo |
| Simone Dumbleton als Co-Ed |
| Jonathan Coffey als Fitzgibbon |
| Michael Caffery als Coast Guard #2 |
| Kyas Sherriff als Airport Attendant |
| Celeste Gosnell als Airport Family |
 | Bradley Gosnell als Airport Family |
| Cayley Gosnell als Airport Family |
| Audrey Gosnell als Airport Family |
| Kurt Duval als Spooky Hotel Bartender |
 | Janis McGavin als Co-Ed Hottie |
| Emily Gosnell als Autograph Seeker |
| Marea Lambert Barker als Autograph Seeker |
 | Kym Jackson als Autograph Seeker |
| Danielle Starkey als Autograph Seeker |
 | Andrew Bryniarski als Cavern Henchman |
 | Craig Behenna als Henchman #1 |
| Keith S. Bullock als Henchman #2 |
 | Jess Harnell als Creature Voices (voice) |
 | Frank Welker als Creature Voices (voice) |
 | Pamela Anderson als Pamela Anderson (uncredited) |
| Joseph Barbera | Executive Producer |
| Robert Engelman | Executive Producer |
| William Hanna | Executive Producer |
| Andrew Mason | Executive Producer |
| Kelley Smith-Wait | Executive Producer |
| Charles Roven | Producer |
| Richard Suckle | Producer |
| Raja Gosnell | Director |
| James Gunn | Screenplay |
| David Eggby | Director of Photography |
| Kent Beyda | Editor |
| Mary Vernieu | Casting |
| Bob Camp | Storyboard |
| Andrew Egiziano | Production Manager |
| Mike Cachuela | Art Department Manager |
| Michael Leung | Visual Effects |
| Larry White | Animation |
| Jay Jackson | Animation |
| Christina Butterfield | Animation Manager |
| Roger Huynh | Compositors |
| Sheryl Benko | Associate Producer |
| Alan Glazer | Co-Producer |
| Stephen Jones | Associate Producer |
| Philip A. Patterson | Associate Producer |
| David Newman | Original Music Composer |
| Margaret Mitchell | Production Controller |
| Craig Titley | Story |
| Bill Boes | Production Design |
| Bill Booth | Art Direction |
| Donna Brown | Art Direction |
| Helen Gabrielle Gliniak | Art Direction |
| Christian Wintter | Art Direction |
| Jodie Allen | Set Decoration |
| Suza Maybury | Set Decoration |
| Matthew Putland | Set Decoration |
| Sandy Wingrove | Set Decoration |
| Leesa Evans | Costume Design |
| Kim Prentice | Art Department Assistant |
| Amiee Clark | Art Department Coordinator |
| Fiona Scott | Assistant Art Director |
| Bernie Childs | Construction Coordinator |
| Gary Cramb | Construction Foreman |
| Gregg Thomas | Greensman |
| Leigh-Alexandra Jacob | Lead Painter |
| Mike Cachuela | Production Illustrator |
| Kirstine Wallis | Sculptor |
| Martin Ash | Set Designer |
| Jasin Boland | Still Photographer |
| Barbara Darragh | Assistant Costume Designer |
| Robyn Elliott | Costume Supervisor |
| Grace Hernandez | Hairstylist |
| Kristelle Gardiner | Makeup Artist |
| Melanie Shepherd | Set Costumer |
| David Childs | Carpenter |
| Didier Levy | CG Supervisor |
| John O'Connell | Choreographer |
| Anthony Mabin | Digital Effects Supervisor |
| Lisa Brennan | Property Master |
| Sherie Bradfute | Software Engineer |
| Vic Kaspar | Sound Recordist |
| Brad Hanson | Stand In |
| Guy Norris | Stunt Coordinator |
| Melissa Barker | Stunts |
| Ben De Luca | Systems Administrators & Support |
| Monica Heideman | Telecine Colorist |
| Stephen Jones | Unit Production Manager |
| Kevin Abercrombie | Utility Stunts |
| Michael Backauskas | Visual Effects Editor |
| Jo Weeks | Script Supervisor |
| Matt Diezel | First Assistant Editor |
| Adam Williams | Gaffer |
| Michael Conelly | Lighting Supervisor |
| Todd Carmody | Lighting Technician |
| Stewart Sorby | Rigging Gaffer |
| Daniel R. Chavez | Executive In Charge Of Post Production |
| Jamie McLennan | Location Manager |
| Paula Marie Duncan | Production Accountant |
| Jennifer Cornwell | Production Coordinator |
| Fiona Searson | Publicist |
| Rod Conder | Boom Operator |
| Katherine Quittner | Music Editor |
| Laura Ziffren | Music Supervisor |
| Gregory Jamrok | Orchestrator |
| Paul 'Salty' Brincat | Production Sound Mixer |
| Scott Sanders | Sound Designer |
| Christopher Assells | Sound Effects Editor |
| Jeff Glueck | Sound Engineer |
| Leonel Pedraza | Sound Mixer |
| Michael D. Wilhoit | Supervising Sound Editor |
| Richard Baneham | Animation Supervisor |
| Jason Bayever | Digital Compositors |
| Brian Cox | Special Effects Supervisor |
| Tohru Patrick Awa | Visual Development |
| Douglas Bloom | Visual Effects |
| Keith Foston | Visual Effects Coordinator |
| Peter Crosman | Visual Effects Supervisor |
| Jenny Groener | Digital Producer |
| Keith Hunter | Modeling |
| Allen Foster | VFX Supervisor |
| Brendon 'Moose' Boyd | Unit Manager |
| Justine Dunn | Set Dresser |
| Glenn Arrowsmith | Dolly Grip |
| Richard Allardice | Key Grip |
| Lesley Vanderwalt | Hair Supervisor |
| Erwin H. Kupitz | Wig Designer |
| John Cox | Animatronics Supervisor |
| Daniel Harvey | Digital Effects Producer |
| Terry Lee | Pilot |
| Philip A. Patterson | First Assistant Director |
| Angella McPherson | Second Assistant Director |
| Drew Bailey | Third Assistant Director |
| Mo Henry | Negative Cutter |
| Ian Dewhurst | Chief Lighting Technician |
| Caitlin McKenna | ADR Voice Casting |
| Kerry Mulgrew | Assistant Production Coordinator |
| Mary Bills | Assistant Production Manager |
| Jamie Underwood | Casting Assistant |
| Michelle Pazer | ADR Editor |
| Todd Egan | Assistant Sound Editor |
| Scott Wolf | Foley Editor |
| Tom Boyd | Musician |
| Kelly Oxford | Supervising ADR Editor |
| Cheryl Budgett | 2D Supervisor |
| William L. Arance | 3D Modeller |
| Jesse Sugarman | CG Animator |
| Lee Romaire | Character Designer |
| Wilmer Lin | Matchmove Supervisor |
| David Orr | Color Timer |
| Joan Nygren | Assistant Makeup Artist |
| Vicki Martin | Costume Assistant |
| Kelly Foreman | Costumer |
| Paul Pattison | Hairdresser |
| Kym Sainsbury | Prosthetics |
| Kazmer Harangozo | Second Second Assistant Director |
| Guy Norris | Second Unit Director |
| Brom | Concept Artist |
| Graeme Callander | Storyboard Artist |
| Weldon Brown | ADR Mixer |
| Michael McNerney | ADR Recordist |
| James Moriana | Foley Artist |
| Nerses Gezalyan | Foley Mixer |
| John O'Brien | Special Effects Assistant |
| Neil Krepela | Additional Visual Effects |
| Jeffrey Schaper | Visual Effects Production Assistant |
| Caroline Grubb | Visual Effects Production Manager |
| Nick McKinless | Stunt Double |
| Mark Broadbent | Assistant Camera |
| Kirsty Bruce | Assistant Editor |
| Kent Pritchett | Colorist |
| David Newman | Conductor |
| Nicole Catino | Music Coordinator |
| Ralph Churchwell | Music Producer |
| Lisa Shaunessy | Accountant |
| Laurie Fish | Assistant Chief Lighting Technician |
| Damian Eggins | Assistant Unit Manager |
| Masoud Aghdasi | Catering |
| Greg Gladstone | CG Artist |
| Jeff McLean | Compositing Lead |
| Bruce Shapiro | Dialogue Coach |
| Jane Dawkins | Extras Casting |
| Trista K. Wahl | Production Assistant |
| Caroline Austin | Production Secretary |
| Nick Lawson | Stunts |
| Laura Harris Atkinson | Dialogue Editor |
| Tory Belleci | Set Designer |
| James Gunn | Story |
| Toby Pease | First Assistant Director |
| Kurt Williams | Visual Effects Producer |
| Andrew Conder | "B" Camera Operator |
| Peter McCaffrey | "A" Camera Operator |
| Roger Lanser | Second Unit Director of Photography |
| Troy Reichman | Second Assistant "B" Camera |
| Melinda Rickman | Second Assistant "A" Camera |
| Ricky Schamburg | First Assistant "B" Camera |
| Adrien Seffrin | First Assistant "A" Camera |
| Grahame Litchfield | Key Grip |
| Adam Shankman | Choreographer |
| Kylie Furneaux | Stunts |
| Lisa Marie Rosenberg | Hairdresser |
| Renee Bowen | Stunts |
| Damian Bradford | Stunts |
| Con Bekiris | Stunts |
| Michelle Comerford | Stunts |
| Mark Chique | Stunts |
| Nicole Downs | Stunts |
| Paul Doyle | Stunts |
| Steve Daddow | Stunts |
| Morgan Evans | Stunts |
| Jane Harman | Stunts |
| Steve Harman | Stunts |
| Scotty Gregory | Stunts |
| Tony Lynch | Stunts |
| Nick Lawson | Stunts |
| Gulliver Page | Stunts |
| Guy Norris | Stunt Coordinator |
| Debbie Santic | Stunts |
| Brett Praed | Stunt Double |
| Yasca Sinigaglia | Stunts |
| Marco Sinigaglia | Stunts |
| Glenn Suter | Stunts |
| Melody Sorensen | Stunt Double |
| Darrell Walshe | Stunts |
| Wilfred Woodrow | Stunts |
| Dino Dos Santos | Stunt Double |
| Robert Chapin | Stunt Double |
| Alan J. Hagge | Systems Administrators & Support |
| Joe Ruby | Thanks |
| Ken Spears | Thanks |
| Stephen Tung Wai | Stunts |
| Jack Wong Wai-Leung | Stunts |
| Audrey Mak | Stunts |
| Fung Wai-Lun | Stunts |
| Choi Kwok-Ping | Stunts |
| Joe Chu Cho-Kuen | Stunts |
| Antonio Caprio | Stunts |
