 | Neve Campbell als Sidney Prescott |
 | Courteney Cox als Gale Weathers |
 | David Arquette als Dewey Riley |
 | Melissa Barrera als Sam Carpenter |
 | Jenna Ortega als Tara Carpenter |
 | Jack Quaid als Richie Kirsch |
 | Mikey Madison als Amber Freeman |
 | Jasmin Savoy Brown als Mindy Meeks-Martin |
 | Dylan Minnette als Wes Hicks |
 | Mason Gooding als Chad Meeks-Martin |
 | Sonia Ammar als Liv Mckenzie |
 | Marley Shelton als Sheriff Judy Hicks |
 | Kyle Gallner als Vince Schneider |
 | Skeet Ulrich als Billy Loomis |
 | Heather Matarazzo als Martha Meeks |
 | Reggie Conquest als Deputy Farney |
 | Chester Tam als Deputy Vinson |
 | James A. Janisse als Film Fails Host |
 | Chelsea Rebecca als Film Fails Host |
 | Brooke Barnhill als Bartender |
 | Stephen West-Rogers als EMT |
 | Milli M. als Reporter |
 | Christopher Speed als Movie Randy |
| Clayton Frank als Party Guest |
| Boomer Mays als Party Guest |
 | Roger L. Jackson als Ghostface (voice) |
 | Drew Barrymore als Principal (voice) / Party Guest (voice) (uncredited) |
 | Adam Brody als Party Guest (voice) (uncredited) |
 | Henry Winkler als Party Guest (voice) (uncredited) |
 | Hayden Panettiere als Party Guest (voice) (uncredited) |
 | Jamie Kennedy als Party Guest (voice) (uncredited) |
 | Matthew Lillard als Flame Thrower Ghostface / Party Guest (voice) (uncredited) |
 | Matt Bettinelli-Olpin als Party Guest (voice) (uncredited) |
 | Tyler Gillett als Party Guest (voice) (uncredited) |
| Iya Labunka als Party Guest (voice) (uncredited) |
 | Kevin Williamson als Party Guest (voice) (uncredited) |
 | Marco Beltrami als Party Guest (voice) (uncredited) |
 | Patrick Lussier als Party Guest (voice) (uncredited) |
 | Julie Plec als Party Guest (voice) (uncredited) |
 | Rian Johnson als Party Guest (voice) (uncredited) |
| Cathy Konrad | Executive Producer |
| Roger Birnbaum | Executive Producer |
| Gary Barber | Executive Producer |
| Wes Craven | In Memory Of |
| Brian Tyler | Original Music Composer |
| Zane D. Bruce | Foley Artist |
| Greg P. Russell | Sound Re-Recording Mixer |
| James Vanderbilt | Screenplay |
| James Vanderbilt | Producer |
| Kevin Williamson | Executive Producer |
| Kevin Williamson | Characters |
| Marianne Maddalena | Executive Producer |
| Cynthia Bergstrom | Key Costumer |
| Matt Bettinelli-Olpin | Director |
| William Sherak | Producer |
| Eliza Pollack Zebert | Dialogue Editor |
| Chad Keith | Production Design |
| Rich Delia | Casting |
| Helen Britten | Set Decoration |
| Brett Jutkiewicz | Director of Photography |
| Jonathan Guggenheim | Art Direction |
| Tyler Gillett | Director |
| Chad Villella | Executive Producer |
| Matthew Llewellyn | Music Editor |
| Joan Shay | Key Hair Stylist |
| Sean Massey | Supervising Sound Editor |
| D. Chris Smith | Sound Designer |
| Michelle Pazer | ADR Editor |
| Karen Baker Landers | Supervising Sound Editor |
| Peter Staubli | Sound Designer |
| John Copeman | Stunt Coordinator |
| Jason Willis | Makeup Artist |
| William Purcell | Special Effects Coordinator |
| Matt Doll | Steadicam Operator |
| Bryan David Moss | Key Hair Stylist |
| Rick Pour | Makeup Department Head |
| Danielle Couture | Art Department Coordinator |
| Jeff Goodwin | Makeup Artist |
| Catherine Bayley | Assistant Set Decoration |
| Mike Repeta | Camera Operator |
| Michel Aller | Editor |
| Anthony Cecere | Stunt Coordinator |
| Larry Long | Sound Mixer |
| Adam Richards | Casting Associate |
| Guy Busick | Screenplay |
| Peter Oillataguerre | Executive Producer |
| Carrie Messina | Hairstylist |
| Caleb Hollenback | Sound Recordist |
| Taylor Stewart | Sound |
| David Young | Sound Engineer |
| Emily Gunshor | Costume Design |
| A. Patrick Storey | Property Master |
| Ron Lynch | Executive Producer |
| Amanda Vinopal | Key Costumer |
| Amanda Vinopal | Costumer |
| Stephen Thompson | Gaffer |
| Mathew Ferrante | Executive In Charge Of Production |
| Emily Kacere | Unit Production Manager |
| Antony Zeller | Foley Mixer |
| Matt Fann | Boom Operator |
| Chelsea Lockhart | Set Dresser |
| Neil Orchard | Best Boy Electric |
| Andy Bader | Digital Imaging Technician |
| Jimmy DiGiandomenico | Dolly Grip |
| Lee Donaldson | Key Grip |
| Beso Kacharava | Foley Artist |
| Paul Neinstein | Producer |
| Brooke Barnhill | Location Manager |
| Biko Gogaladze | Foley Artist |
| Giorgi Lekishvili | Foley Mixer |
| Scott Oberholzer | Second Assistant Director |
| Patrick J. Borowiak | First Assistant Camera |
| Jeremy Lee | Rigging Grip |
| Dalia Dalili | Set Costumer |
| Dalia Dalili | Costumer |
| George Murgulia | Foley Editor |
| Angelo Raguso | Sound Mixer |
| Alexander Sanikidze | Foley Editor |
| George Corrie | Special Effects Technician |
| Dallas Clarke Thomas | Graphic Designer |
| Kelly Sweitzer | Scenic Artist |
| Wes Simpkins | Storyboard Artist |
| Catherine Corkery | Costume Assistant |
| Jared Major | Set Costumer |
| Taylor Woodell | Extras Casting |
| Ryan Byrd | Rigging Grip |
| Russell Major | Location Assistant |
| Kara McGee | Script Supervisor |
| The Newton Brothers | Sound |
| James Jenkins | Makeup Artist |
| Matt Hobbs | Art Department Assistant |
| Donnie Little | Sound Engineer |
| Timmy Broderick | Visual Effects Producer |
