 | Morgan Freeman als Detective Lt. William Somerset |
 | Brad Pitt als Detective David Mills |
 | Gwyneth Paltrow als Tracy Mills |
 | John Cassini als Officer Davis |
 | Peter Crombie als Dr. O'Neill |
 | Reg E. Cathey als Dr. Santiago |
 | R. Lee Ermey als Police Captain |
 | Daniel Zacapa als Detective Taylor at First Murder |
 | Andrew Kevin Walker als Dead Man at 1st Crime Scene |
 | George Christy als Workman at Door of Somerset's Office |
 | Endre Hules als Cab Driver |
 | Hawthorne James als George the Night Guard at the Library |
 | Bob Mack als Gluttony Victim |
| William Davidson als First Guard at the Library |
| Bob Collins als Second Guard at the Library |
| Jimmy Dale Hartsell als Library Janitor |
 | Richard Roundtree als Dist. Atty. Martin Talbot |
| Charline Su als TV News Reporter |
 | Dominique Jennings als TV News Reporter |
 | Allan Kolman als First Forensic Man in the Law Office |
| Beverly Burke als TV Anchor Woman |
| Gene Borkan als Eli Gould - Greed Victim |
 | Julie Araskog als Mrs. Gould |
| Mario Di Donato als Fingerprint Forensic Man in Law Office |
 | Alfonso Freeman als Fingerprint Technician |
 | John C. McGinley als California |
 | Harrison White als Cop on SWAT Team |
 | Bob Stephenson als Cop on SWAT Team |
 | Michael Reid MacKay als Victor - Sloth Victim |
 | Richard Portnow als Dr. Beardsley |
| Tudor Sherrard als Coupon Man Outside Pizza Parlor |
 | Mark Boone Junior als Greasy F.B.I. Man |
| Pamala Tyson als Thin Vagrant by John Doe's Apartment |
 | Lennie Loftin als Policeman Who Takes Statement from Vagrant |
| Sarah Reinhardt als Police Sketch Artist |
 | Emily Wagner als Detective Sara at John Doe's Apartment |
| Martin Serene als Wild Bill |
 | Michael Massee als Man in Booth at Massage Parlor |
| David Correia als First Cop at Massage Parlor |
| Ron Blair als Second Cop at Massage Parlor |
| Jennifer Mueller als Lust Victim |
 | Leland Orser als Crazed Man in Massage Parlor |
 | Lexie Bigham als Sweating Cop at Massage Parlor |
 | Evan Mirand als Paramedic at Massage Parlor |
 | Paul Eckstein als Paramedic at Massage Parlor |
 | Harris Savides als 911 Operator |
 | Rachel Flanagan als Additional 911 Operator |
 | Heidi Schanz als Pride Victim |
 | Brian Evers als Duty Sergeant |
 | Shannon Wilcox als Woman Cop Behind Desk |
 | Richard Schiff als Mark Swarr |
| James Deeth als Helicopter Pilot |
| John Santin als Helicopter Pilot |
 | Charles A. Tamburro als SWAT Helicopter Pilot |
 | Richmond Arquette als Delivery Man |
 | Duffy Gaver als Marksman in Helicopter |
 | Kevin Spacey als John Doe |
 | Charles S. Dutton als Cop (uncredited) |
 | Arthur Max als Man in Library (uncredited) |
| Phyllis Carlyle | Producer |
| Arnold Kopelson | Producer |
| Anne Kopelson | Executive Producer |
| Howard Shore | Original Music Composer |
| Darius Khondji | Director of Photography |
| Richard Francis-Bruce | Editor |
| Kerry Barden | Casting |
| Billy Hopkins | Casting |
| Suzanne Smith Crowley | Casting |
| Arthur Max | Production Design |
| Gary Wissner | Art Direction |
| Clay A. Griffith | Set Decoration |
| Michael Kaplan | Costume Design |
| Dan Kolsrud | Executive Producer |
| David Fincher | Director |
| Elizabeth Lapp | Set Designer |
| Elinor Bardach | Costume Supervisor |
| Robert S. Mendelsohn | Unit Production Manager |
| Allan Wertheim | Unit Production Manager |
| Ted Zachary | Executive In Charge Of Production |
| Joe Fineman | Executive In Charge Of Post Production |
| Michele Platt | Associate Producer |
| Ric Keeley | Post Production Supervisor |
| Barry Chusid | Assistant Art Director |
| Lori Rowbotham | Set Designer |
| Hugo Santiago | Set Designer |
| Jan O'Connell | Art Department Coordinator |
| Chris Gibbin | Leadman |
| Wendy Cox | Production Coordinator |
| Paul Hargrave | Location Manager |
| Conrad W. Hall | Camera Operator |
| Michael A. Chavez | Camera Operator |
| Brad Edmiston | First Assistant Camera |
| David Emmerichs | Steadicam Operator |
| Dale Myrand | Steadicam Operator |
| Peter Sorel | Still Photographer |
| Willie D. Burton | Production Sound Mixer |
| Marvin E. Lewis | Boom Operator |
| Danny Cangemi | Special Effects Supervisor |
| Peter Albiez | Special Effects Coordinator |
| Greg Kimble | Visual Effects Supervisor |
| Aisha Coley | Casting Associate |
| Angie Rubin | Music Editor |
| Ellen Segal | Music Editor |
| Robert C. Lusted | First Assistant Editor |
| William Hoy | Additional Editing |
| Ren Klyce | Sound Designer |
| Patrick Dodd | Supervising Sound Editor |
| Ren Klyce | Sound Effects Editor |
| Kim B. Christensen | Sound Effects Editor |
| Jennifer L. Ware | Sound Effects Editor |
| Robert J. Litt | Sound Re-Recording Mixer |
| Elliot Tyson | Sound Re-Recording Mixer |
| Rick Hart | Sound Re-Recording Mixer |
| Bert Dovo | Orchestrator |
| John Lissauer | Orchestrator |
| Russell McEntyre | Transportation Coordinator |
| Wayne Stone | Transportation Captain |
| Chuck Picerni Jr. | Stunt Coordinator |
| Sanford Panitch | Co-Producer |
| Nana Greenwald | Co-Producer |
| Stephen Joel Brown | Co-Producer |
| Richard Saperstein | Co-Executive Producer |
| Lynn Harris | Co-Executive Producer |
| Gianni Nunnari | Executive Producer |
| William Davidson | Construction Foreman |
| William C. Gerrity | Line Producer |
| Monty Westmore | Makeup Artist |
| Becky Ochoa | Hair Designer |
| Mark Graziano | Post Production Supervisor |
| Larry Velasco | Set Costumer |
| Ceán Chaffin | Thanks |
| Vincent Landay | Thanks |
| Michael Hancock | Makeup Artist |
| Andrea Gargano | Color Timer |
| Yvan Lucas | Color Timer |
| George Alden | Driver |
| Kim Taylor-Coleman | Casting Assistant |
| Jennifer McNamara | Casting Assistant |
| David Behle | Sound Recordist |
| Philip Rogers | Sound Recordist |
| Jack Keller | Sound Recordist |
| John Nutt | Dialogue Editor |
| Francesca Dodd | Dialogue Editor |
| Joan E. Chapman | ADR Editor |
| Jeff Watts | ADR Editor |
| Patrick Dodd | ADR Supervisor |
| Mark Levinson | ADR Editor |
| Marnie Moore | Foley Artist |
| Margie O'Malley | Foley Artist |
| Cori Glazer | Script Supervisor |
| Roy 'Bucky' Moore | Property Master |
| Jeremy Molod | Foley Mixer |
| Richard Duarte | Foley Mixer |
| Robert Bonino | Construction Coordinator |
| Daren Dochterman | Production Illustrator |
| Shawn Albro | Painter |
| Alan Alvarado | Propmaker |
| Moto Hata | Sculptor |
| Elizabeth Ragali | Set Decoration Buyer |
| Christopher Casey | Set Dressing Artist |
| Nicholas C. John | Standby Painter |
| Steve Boeddeker | Assistant Sound Designer |
| Malcolm Fife | Foley Editor |
| William B. Doane | Special Effects |
| Tim Thompson | Visual Effects Coordinator |
| J.W. Kompare | Visual Effects Editor |
| Peter Frankfurt | Visual Effects Producer |
| LaFaye Baker | Stunts |
| Harris Savides | Additional Photography |
| Donald M. Morgan | Aerial Camera |
| Michael Charbonnet | Camera Technician |
| Michael S. Adler | Electrician |
| Claudio Miranda | Gaffer |
| Nico Bally | Grip |
| Michael J. Coo | Key Grip |
| Thomas P. Powell | Lighting Technician |
| Joseph Graham | Rigging Grip |
| Melodie McDaniel | Still Photographer |
| Dale Caldwell | Color Timer |
| Ian Crockett | Post Production Assistant |
| Fred Jove | Location Scout |
| Tom Boyd | Musician |
| Bonnie Alden | Driver |
| Jose Majica | Chef |
| Ronald E. Hairston | Craft Service |
| Robert Grindrod | Production Accountant |
| Paul Prokop | Production Controller |
| François Frey | Publicist |
| Kenneth H. Frith Jr. | Set Production Assistant |
| Thomas Brader | Stand In |
| Jacques Rey | Storyboard Artist |
| Susan Steinlauf-Pascal | Unit Publicist |
| John S. Dorsey | Art Department Assistant |
| Marsha Bozeman | Costumer |
| Jean Ann Black | Makeup Supervisor |
| Leonard Bram | Additional Second Assistant Director |
| Frank Davis | Second Assistant Director |
| Craig A. Pinckes | Second Second Assistant Director |
| Jim Feldman | Concept Artist |
| Bruce Bellamy | Swing |
| Kyle Cooper | Title Designer |
| Thomas J. O'Connell | ADR Mixer |
| Rick Canelli | ADR Recordist |
| Erik R. Kraber | Assistant Dialogue Editor |
| Robert W. Harris | Utility Sound |
| Scott Wilder | Stunt Double |
| William E. Fitch | Best Boy Grip |
| David Sanchez | Camera Loader |
| Michael Brennan | Dolly Grip |
| Brent Beal | Second Assistant Camera |
| Tom Barrett | Assistant Editor |
| Gary Burritt | Negative Cutter |
| Flint Maloney | Assistant Location Manager |
| Joe Johnston | Location Assistant |
| Lucas Richman | Conductor |
| Rachel Flanagan | Music Consultant |
| Mark Kaufman | Music Coordinator |
| Charles A. Tamburro | Aerial Coordinator |
| Craig Albrecht | Art Department Production Assistant |
| John L. Anderson | Assistant Production Coordinator |
| Jerri Whiteman | First Assistant Accountant |
| Larry J. Aube | Key Rigging Grip |
| Robert M. Rey | Medical Consultant |
| Brad Davis | Payroll Accountant |
| Gary A. Martin | Production Assistant |
| Janet Ingram | Production Secretary |
| Patrick Tatopoulos | Conceptual Illustrator |
| Michael Alan Kahn | First Assistant Director |
| Andrew Kevin Walker | Writer |
| Gary Archer | Prosthetics |
| Armen Ksajikian | Musician |
| Kane Hodder | Stunts |
| Charlie Picerni | Stunts |
| Henry Kingi | Stunts |
| Bob Brown | Stunts |
| Tim A. Davison | Stunts |
| Maria Norman | Executive Assistant |
| Janet Brady | Stunts |
| Rob Bottin | Makeup Effects Designer |
| Kenny Endoso | Stunts |
| Sandy Berumen | Stunts |
