 | Marlon Wayans als Alan / Russell / Dawn / Jasper / Ethan / Baby Pete / Lynette |
 | Bresha Webb als Marie |
 | Michael Ian Black als Doug |
 | Molly Shannon als Linda |
 | Glynn Turman als Leland |
 | Debbi Morgan als Janet |
 | Robert Pralgo als Dr. Williams |
 | Jwaundace Candece als Prison Guard |
| Jason Graham als Dr. Ellis |
 | Casey Hendershot als Trucker |
 | Grace Junot als Dr. Greenberg |
| Robert Pralgo als Dr. Theodore Williams |
 | Scott Hunter als Trucker #2 |
| Michael Tiddes | Director |
| Marlon Wayans | Writer |
| Rick Alvarez | Writer |
| Mike Glock | Writer |
| Rick Alvarez | Producer |
| Tracey Landon | Executive Producer |
| Nathan Talbert Reimann | Producer |
| Michael Tiddes | Executive Co-Producer |
| Marlon Wayans | Producer |
| John Debney | Original Music Composer |
| Lawrence Jordan | Editor |
| Raylin Sabo | Casting |
| Mary Vernieu | Casting |
| Ermanno Di Febo-Orsini | Production Design |
| Jerry M. Sonnenberg | Art Direction |
| Sean Britts | Set Decoration |
| Melinda Sanders | Set Decoration |
| Carol Ramsey | Costume Design |
| Ana Ramos Dominguez | Visual Effects Producer |
| Don Burgess | Director of Photography |
| Jared Hasselbach | VFX Artist |
| Grady Allen Bishop | Stunts |
| Chuck Borden | Stunts |
